Genetic ancestry effects on the distribution of toll-like receptors (TLRs) gene polymorphisms in a population of the Atlantic Forest, Sao Paulo, Brazil

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorGUIMARAES, Lilian O.
dc.contributor.authorBAJAY, Miklos Maximiliano
dc.contributor.authorMONTEIRO, Eliana F.
dc.contributor.authorWUNDERLICH, Gerhard
dc.contributor.authorSANTOS, Sidney E.
dc.contributor.authorKIRCHGATTER, Karin
dc.date.accessioned2018-03-06T15:29:38Z
dc.date.available2018-03-06T15:29:38Z
dc.date.issued2018
dc.description.abstractThe innate immune system governed by toll -like receptors (TLRs) provides the first line of defense against pathogens. Surface -localized TLR1 and TLR6 are known to detect parasite components. TLR encoding genes were shown to display signatures of recent positive selection in Europeans and might be involved in local adaptation at immune -related genes. To verify the influence of Brazilian population admixture on the distribution of polymorphisms in TLRs, we analyzed the genotype frequencies of 24 polymorphisms distributed across five TLR genes in a Southeastern Brazilian population where autochthonous cases of malaria occur in small foci of transmission. The estimation of ancestry showed mainly European ancestry (63%) followed by African ancestry (22%). Mean proportions of European ancestry differed significantly between the genotypes of the TLR1 (1602S) gene and in the TLR6 (P249S) gene. The chance of having the G allele in TLR1 gene increases as European ancestry increases as well as the chance of having the T allele in the TLR6 gene. The 602S allele is related to a ""hypo -responsiveness"" possibly explaining the high prevalence of asymptomatic malaria cases in areas of Southeastern Brazil. Our results underline the necessity to include informative ancestry markers in genetic association studies in order to avoid biased results.
dc.description.indexMEDLINE
dc.description.sponsorshipFAPESP [2011/50492-1]
dc.description.sponsorshipCAPES scholarship
dc.description.sponsorshipFAPESP
dc.identifier.citationHUMAN IMMUNOLOGY, v.79, n.2, p.101-108, 2018
dc.identifier.doi10.1016/j.humimm.2017.11.007
dc.identifier.eissn1879-1166
dc.identifier.issn0198-8859
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/25853
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofHuman Immunology
dc.rightsrestrictedAccess
dc.rights.holderCopyright ELSEVIER SCIENCE INC
dc.subjectTLRs
dc.subjectGenetic polymorphism
dc.subjectGene frequency
dc.subjectBrazilian population
dc.subject.othermultilocus genotype data
dc.subject.otherimmune-response
dc.subject.otherinnate immunity
dc.subject.othermalaria
dc.subject.otherassociation
dc.subject.otherinference
dc.subject.otheradmixture
dc.subject.otherhumans
dc.subject.othersubstructure
dc.subject.otherevolutionary
dc.subject.wosImmunology
dc.titleGenetic ancestry effects on the distribution of toll-like receptors (TLRs) gene polymorphisms in a population of the Atlantic Forest, Sao Paulo, Brazil
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalBAJAY, Miklos Maximiliano:Univ Sao Paulo, Dept Genet, Piracicaba, SP, Brazil
hcfmusp.author.externalWUNDERLICH, Gerhard:Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Sao Paulo, SP, Brazil
hcfmusp.author.externalSANTOS, Sidney E.:Fed Univ Para, Lab Human & Med Genet, Belem, Para, Brazil
hcfmusp.citation.scopus8
hcfmusp.contributor.author-fmusphcLILIAN DE OLIVEIRA GUIMARAES
hcfmusp.contributor.author-fmusphcELIANA FERREIRA MONTEIRO
hcfmusp.contributor.author-fmusphcKARIN KIRCHGATTER
hcfmusp.description.beginpage101
hcfmusp.description.endpage108
hcfmusp.description.issue2
hcfmusp.description.volume79
hcfmusp.origemWOS
hcfmusp.origem.pubmed29175392
hcfmusp.origem.scopus2-s2.0-85035106661
hcfmusp.origem.wosWOS:000424316000006
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
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