Long-term lithium treatment increases intracellular and extracellular brain-derived neurotrophic factor (BDNF) in cortical and hippocampal neurons at subtherapeutic concentrations

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorDE-PAULA, Vanessa J.
dc.contributor.authorGATTAZ, Wagner F.
dc.contributor.authorFORLENZA, Orestes V.
dc.date.accessioned2017-04-07T15:11:21Z
dc.date.available2017-04-07T15:11:21Z
dc.date.issued2016
dc.description.abstractObjectives: The putative neuroprotective effects of lithium treatment rely on the fact that it modulates several homeostatic mechanisms involved in the neurotrophic response, autophagy, oxidative stress, inflammation, and mitochondrial function. Lithium is a well-established therapeutic option for the acute and long-term management of bipolar disorder and major depression. The aim of this study was to evaluate the effects of subtherapeutic and therapeutic concentrations of chronic lithium treatment on brain-derived neurotrophic factor (BDNF) synthesis and secretion. Methods: Primary cultures of cortical and hippocampal neurons were treated with different subtherapeutic (0.02 and 0.2 mM) and therapeutic (2 mM) concentrations of chronic lithium treatment in cortical and hippocampal cell culture. Results: Lithium treatment increased the intracellular protein expression of cortical neurons (10% at 0.02 mM) and hippocampal neurons (28% and 14% at 0.02 mM and 0.2 mM, respectively). Extracellular BDNF of cortical neurons increased 30% and 428% at 0.02 and 0.2 mM, respectively and in hippocampal neurons increased 44% at 0.02 mM. Conclusion: The present study indicates that chronic, low-dose lithium treatment -up-regulates BDNF production in primary neuronal cell culture.
dc.description.indexMEDLINE
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo
dc.description.sponsorshipSao Paulo Research Foundation [09/52825-8, 2011/19892-3, 2016/01302-9]
dc.identifier.citationBIPOLAR DISORDERS, v.18, n.8, p.692-695, 2016
dc.identifier.doi10.1111/bdi.12449
dc.identifier.eissn1399-5618
dc.identifier.issn1398-5647
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/18935
dc.language.isoeng
dc.publisherWILEY-BLACKWELL
dc.relation.ispartofBipolar Disorders
dc.rightsrestrictedAccess
dc.rights.holderCopyright WILEY-BLACKWELL
dc.subjectBDNF
dc.subjectchronic lithium treatment
dc.subjectcortical neurons
dc.subjecthippocampal neurons
dc.subjectlow-dose lithium treatment
dc.subject.otherprotein-levels
dc.subject.othermessenger-rna
dc.subject.otherautophagy
dc.subject.otherdisease
dc.subject.otherdisorder
dc.subject.othercells
dc.subject.wosClinical Neurology
dc.subject.wosNeurosciences
dc.subject.wosPsychiatry
dc.titleLong-term lithium treatment increases intracellular and extracellular brain-derived neurotrophic factor (BDNF) in cortical and hippocampal neurons at subtherapeutic concentrations
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.citation.scopus29
hcfmusp.contributor.author-fmusphcVANESSA DE JESUS RODRIGUES DE PAULA
hcfmusp.contributor.author-fmusphcWAGNER FARID GATTAZ
hcfmusp.contributor.author-fmusphcORESTES VICENTE FORLENZA
hcfmusp.description.beginpage692
hcfmusp.description.endpage695
hcfmusp.description.issue8
hcfmusp.description.volume18
hcfmusp.origemWOS
hcfmusp.origem.pubmed27882645
hcfmusp.origem.scopus2-s2.0-85008430109
hcfmusp.origem.wosWOS:000392817000008
hcfmusp.publisher.cityHOBOKEN
hcfmusp.publisher.countryUSA
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