Amphotericin B Plasma Monitoring for One Burn Child Using High-Performance Liquid Chromatography

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSANCHES-GIRAUD, Cristina
dc.contributor.authorGOMEZ, David S.
dc.contributor.authorCAMPOS, Edvaldo V.
dc.contributor.authorAZEVEDO, Rodrigo P. de
dc.contributor.authorDESPINOY, Alessandra
dc.contributor.authorPEREZ, Grazziela S.
dc.contributor.authorFERREIRA, Marcus C.
dc.contributor.authorSANTOS, Silvia R. C. J.
dc.date.accessioned2017-11-27T16:20:35Z
dc.date.available2017-11-27T16:20:35Z
dc.date.issued2011
dc.description.abstractA bioanalytical micromethod was described for the quantification of amphotericin B in plasma by HPLC. The method showed high absolute recovery, good linearity (0.1-10.0 mu g/mL, r(2) = 0.999), sensitivity (limits of quantification: 0.1 mu g/mL), and acceptable stability. Inter/intraday precisions were 6.8 %/23 % and mean accuracy was 94.3 %. The method was applied to plasma monitoring of one burn child, 3 years old, 25 kg, thermal injury (18 % total burn surface area - TBSA). Amphotericin B (1 mg/kg) was prescribed from 24(tg) to 35(tg) day of the accident and plasma monitoring and pharmacokinetics was performed by serial blood collections on 274 and 354 days post burn. Plasma concentrations obtained were respectively 0.7 mu g/mL and 1.2 mu g/mL. Pharmacokinetics at both periods (27(tg) vs 35(tg) day) also was compared: 13.8 vs 14.3 h (t(1/2 beta)); 0.5 vs 03 mL/min.kg (CL(T)) and 0.65 vs 038 L/kg (Vd(ss)). In conclusion, drug plasma monitoring by HPLC was quite useful to guarantee low risk and drug efficacy in a paediatric burn patient.
dc.description.indexWoS
dc.description.sponsorshipCAPES
dc.description.sponsorshipCNPq
dc.description.sponsorshipFAPESP
dc.identifier.citationLATIN AMERICAN JOURNAL OF PHARMACY, v.30, n.8, p.1468-1474, 2011
dc.identifier.issn0326-2383
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/22455
dc.language.isoeng
dc.publisherCOLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES
dc.relation.ispartofLatin American Journal of Pharmacy
dc.rightsrestrictedAccess
dc.rights.holderCopyright COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES
dc.subjectAmphotericin B
dc.subjectBurn child
dc.subjectDrug plasma monitoring
dc.subjectHPLC-UV
dc.subjectPharmacokinetics
dc.subject.otherinternal standard
dc.subject.othermalignant diseases
dc.subject.otherhuman-serum
dc.subject.otherpharmacokinetics
dc.subject.otherassay
dc.subject.otherpharmacodynamics
dc.subject.otherextraction
dc.subject.wosPharmacology & Pharmacy
dc.titleAmphotericin B Plasma Monitoring for One Burn Child Using High-Performance Liquid Chromatography
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalSANCHES-GIRAUD, Cristina:Univ Sao Paulo, Fac Pharmaceut Sci, Sao Paulo, Brazil
hcfmusp.author.externalCAMPOS, Edvaldo V.:Univ Sao Paulo, Hosp Clin, Fac Med, BR-05508 Sao Paulo, Brazil
hcfmusp.author.externalPEREZ, Grazziela S.:Univ Sao Paulo, Fac Pharmaceut Sci, Sao Paulo, Brazil
hcfmusp.author.externalSANTOS, Silvia R. C. J.:Univ Sao Paulo, Fac Pharmaceut Sci, Sao Paulo, Brazil
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcDAVID DE SOUZA GOMEZ
hcfmusp.contributor.author-fmusphcRODRIGO PALACIO DE AZEVEDO
hcfmusp.contributor.author-fmusphcALESSANDRA DESPINOY
hcfmusp.contributor.author-fmusphcMARCUS CASTRO FERREIRA
hcfmusp.description.beginpage1468
hcfmusp.description.endpage1474
hcfmusp.description.issue8
hcfmusp.description.volume30
hcfmusp.origemWOS
hcfmusp.origem.scopus2-s2.0-84856266693
hcfmusp.origem.wosWOS:000298869100002
hcfmusp.publisher.cityLA PLATA
hcfmusp.publisher.countryARGENTINA
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Artigos e Materiais de Revistas Científicas - HC/ICHC
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