Stochastic model of contact inhibition and the proliferation of melanoma in situ

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMORAIS, Mauro Cesar Cafundo
dc.contributor.authorSTUHL, Izabella
dc.contributor.authorSABINO, Alan U.
dc.contributor.authorLAUTENSCHLAGER, Willian W.
dc.contributor.authorQUEIROGA, Alexandre S.
dc.contributor.authorTORTELLI JR., Tharcisio Citrangulo
dc.contributor.authorCHAMMAS, Roger
dc.contributor.authorSUHOV, Yuri
dc.contributor.authorRAMOS, Alexandre F.
dc.date.accessioned2017-10-24T13:17:09Z
dc.date.available2017-10-24T13:17:09Z
dc.date.issued2017
dc.description.abstractContact inhibition is a central feature orchestrating cell proliferation in culture experiments; its loss is associated with malignant transformation and tumorigenesis. We performed a co-culture experiment with human metastatic melanoma cell line (SKMEL-147) and immortalized keratinocyte cells (HaCaT). After 8 days a spatial pattern was detected, characterized by the formation of clusters of melanoma cells surrounded by keratinocytes constraining their proliferation. In addition, we observed that the proportion of melanoma cells within the total population has increased. To explain our results we propose a spatial stochastic model (following a philosophy of the Widom-Rowlinson model from Statistical Physics and Molecular Chemistry) which considers cell proliferation, death, migration, and cell-to-cell interaction through contact inhibition. Our numerical simulations demonstrate that loss of contact inhibition is a sufficient mechanism, appropriate for an explanation of the increase in the proportion of tumor cells and generation of spatial patterns established in the conducted experiments.
dc.description.indexMEDLINE
dc.description.sponsorshipCAPES [88881.062174/2014-01]
dc.description.sponsorshipMath Department, University of Denver
dc.description.sponsorshipPrograma de Educacao Tutorial - MEC/SESu
dc.description.sponsorshipMath Department, Penn State University
dc.identifier.citationSCIENTIFIC REPORTS, v.7, article ID 8026, 9p, 2017
dc.identifier.doi10.1038/s41598-017-07553-6
dc.identifier.issn2045-2322
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/21865
dc.language.isoeng
dc.publisherNATURE PUBLISHING GROUP
dc.relation.ispartofScientific Reports
dc.rightsopenAccess
dc.rights.holderCopyright NATURE PUBLISHING GROUP
dc.subject.othermathematical oncology
dc.subject.othermechanical feedback
dc.subject.othercancer development
dc.subject.othertumor progression
dc.subject.otherhippo pathway
dc.subject.othercell
dc.subject.othergrowth
dc.subject.otherinvasion
dc.subject.otherbiology
dc.subject.othercarcinogenesis
dc.subject.wosMultidisciplinary Sciences
dc.titleStochastic model of contact inhibition and the proliferation of melanoma in situ
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryInglaterra
hcfmusp.affiliation.countryHungria
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.affiliation.countryisohu
hcfmusp.affiliation.countryisogb
hcfmusp.author.externalSTUHL, Izabella:Univ Denver, Dept Math, Denver, CO USA
hcfmusp.author.externalQUEIROGA, Alexandre S.:Univ Sao Paulo, Escola Artes, Cincias Humanidades, BR-03828000 Sao Paulo, SP, Brazil; Univ Denver, Dept Math, Denver, CO USA
hcfmusp.author.externalTORTELLI JR., Tharcisio Citrangulo:Univ Debrecen, 4DAMPT, Debrecen, Hungary
hcfmusp.author.externalSUHOV, Yuri:Univ Sao Paulo, Dept Radiol Oncol, Fac Med, Sao Paulo, Brazil; Univ Sao Paulo, Escola Artes, Cincias Humanidades, BR-03828000 Sao Paulo, SP, Brazil; Univ Denver, Dept Math, Denver, CO USA; Univ Cambridge, DPMMS, Cambridge, England
hcfmusp.citation.scopus10
hcfmusp.contributor.author-fmusphcALAN UTSUNI SABINO
hcfmusp.contributor.author-fmusphcWILLIAN WAGNER LAUTENSCHLAGER
hcfmusp.contributor.author-fmusphcROGER CHAMMAS
hcfmusp.contributor.author-fmusphcALEXANDRE FERREIRA RAMOS
hcfmusp.description.articlenumber8026
hcfmusp.description.volume7
hcfmusp.origemWOS
hcfmusp.origem.pubmed28808257
hcfmusp.origem.scopus2-s2.0-85027460114
hcfmusp.origem.wosWOS:000407559100026
hcfmusp.publisher.cityLONDON
hcfmusp.publisher.countryENGLAND
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