Lymphocyte subsets and Langerhans cells in the skin of kidney transplant recipients under three different immunosuppressive regimens

Imagem de Miniatura
Arquivos
art_V_Lymphocyte_subsets_and_Langerhans_cells_in_the_skin_2022.PDF (549.82 KB)
Citações na Scopus
0
Tipo de produção
article
Data de publicação
2022
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY
Autores
SALDANHA, M. G.
Citação
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, v.36, n.12, p.2466-2472, 2022
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background Renal transplant recipients (RTRs) are at increased risk of developing skin cancer; however, the role of immunosuppression is not yet fully understood. In this study, we evaluated the immunohistochemical changes in the skin of RTRs under three different immunosuppression regimens: mTOR inhibitors (mTORi), sirolimus or everolimus, mycophenolic acid (MPA) precursors such as mycophenolate sodium or mofetil, or azathioprine (AZA). Methods We evaluated biopsies of sun-exposed and sun-protected skin for immunohistochemical quantification of B lymphocytes (CD20(+)), T lymphocytes (CD3(+), CD4(+), and CD8(+)), and Langerhans cells (LCs) (CD1a(+)) in 30 RTRs and 10 healthy controls. The RTRs were divided into three groups: mTORi (n = 10), MPA (n = 10), and AZA (n = 10). Results No differences were observed in the number of B lymphocytes. However, a significant decrease in the number of T lymphocytes and LCs was observed in both sun-protected and sun-exposed skin in the AZA and MPA groups, although to a lesser degree in the latter group. The skin of the mTORi group did not differ from that of the control group in terms of the number of B and T lymphocytes and LCs. Conclusions Patients treated with mTORi exhibit preserved cellular elements related to cutaneous immune surveillance. The use of AZA induced a greater degree of skin immunosuppression than in the control group, as demonstrated by the decrease in T lymphocytes and LCs.
Palavras-chave
URI
https://observatorio.fm.usp.br/handle/OPI/50673
Referências
  1. Abbas AK., 2019, BASIC IMMUNOLOGY FUN, V196
  2. Alberu J, 2011, TRANSPLANTATION, V92, P303, DOI 10.1097/TP.0b013e3182247ae2
  3. Attard NR, 2012, PHOTOCH PHOTOBIO SCI, V11, P62, DOI 10.1039/c1pp05194f
  4. Bottomley MJ, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20082009
  5. Brem R, 2012, PHOTOCHEM PHOTOBIOL, V88, P5, DOI 10.1111/j.1751-1097.2011.01043.x
  6. Carneiro RV, 2005, CLIN TRANSPLANT, V19, P115, DOI 10.1111/j.1399-0012.2004.00311.x
  7. Cheng JY, 2018, JAMA DERMATOL, V154, P60, DOI 10.1001/jamadermatol.2017.4506
  8. Chung CL, 2019, GEROSCIENCE, V41, P861, DOI 10.1007/s11357-019-00113-y
  9. Coghill AE, 2016, AM J TRANSPLANT, V16, P565, DOI 10.1111/ajt.13596
  10. de Fijter JW, 2017, TRANSPLANTATION, V101, P45, DOI 10.1097/TP.0000000000001447
  11. Ducloux D, 1998, TRANSPLANTATION, V65, P1270, DOI 10.1097/00007890-199805150-00022
  12. Galvao MM, 1998, J AM ACAD DERMATOL, V38, P38, DOI 10.1016/S0190-9622(98)70536-5
  13. Gupta V, 2019, CLIN DERMATOL, V37, P430, DOI 10.1016/j.clindermatol.2019.07.010
  14. Harwood CA, 2017, BRIT J DERMATOL, V177, P1217, DOI 10.1111/bjd.15956
  15. Jiyad Z, 2016, AM J TRANSPLANT, V16, P3490, DOI 10.1111/ajt.13863
  16. Jung JW, 2016, INT J CANCER, V138, P281, DOI 10.1002/ijc.29450
  17. Koehl GE, 2007, TRANSPLANTATION, V83, P607, DOI 10.1097/01.tp.0000253756.69243.65
  18. Lanz J, 2019, JAMA DERMATOL, V155, P66, DOI 10.1001/jamadermatol.2018.4406
  19. Levey AS, 2020, KIDNEY INT, V97, P1117, DOI 10.1016/j.kint.2020.02.010
  20. Levey AS, 2009, ANN INTERN MED, V150, P604, DOI 10.7326/0003-4819-150-9-200905050-00006
  21. Moura AKA, 2018, ARCH DERMATOL RES, V310, P139, DOI 10.1007/s00403-018-1806-z
  22. O'Neill JO, 2006, J HEART LUNG TRANSPL, V25, P1186, DOI 10.1016/j.healun.2006.06.010
  23. Page SJS, 2015, AUSTRALAS J DERMATOL, V56, P77, DOI 10.1111/ajd.12259
  24. Rahatli S, 2020, EXP CLIN TRANSPLANT, V18, P470, DOI 10.6002/ect.2018.0177
  25. Ramsay HM, 2002, BRIT J DERMATOL, V147, P950, DOI 10.1046/j.1365-2133.2002.04976.x
  26. Rangwala S, 2011, BRIT J DERMATOL, V165, P953, DOI 10.1111/j.1365-2133.2011.10507.x
  27. Robson R, 2005, AM J TRANSPLANT, V5, P2954, DOI 10.1111/j.1600-6143.2005.01125.x
  28. Sandvik LF, 2014, ACTA DERM-VENEREOL, V94, P173, DOI 10.2340/00015555-1679
  29. Savoia P, 2017, CURR DRUG TARGETS, V18, P436, DOI 10.2174/1389450117666160112115524
  30. Shao EX, 2022, TRANSPLANTATION, V106, P1078, DOI 10.1097/TP.0000000000003827
  31. Streilein J W, 1989, Immunol Ser, V46, P73
  32. Strobel SB, 2018, BRIT J DERMATOL, V179, P405, DOI 10.1111/bjd.16477
  33. THIERS BH, 1984, J INVEST DERMATOL, V82, P223, DOI 10.1111/1523-1747.ep12260055

Coleções
Artigos e Materiais de Revistas Científicas - FM/MPT
Carregar mais