Evaluation of glomerular sirtuin-1 and claudin-1 in the pathophysiology of nondiabetic focal segmental glomerulosclerosis

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLOPES-GONCALVES, Guilherme
dc.contributor.authorCOSTA-PESSOA, Juliana Martins
dc.contributor.authorPIMENTA, Ruan
dc.contributor.authorTOSTES, Ana Flavia
dc.contributor.authorSILVA, Eloisa Martins da
dc.contributor.authorLEDESMA, Felipe Lourenco
dc.contributor.authorMALHEIROS, Denise Maria Avancini Costa
dc.contributor.authorZATZ, Roberto
dc.contributor.authorTHIEME, Karina
dc.contributor.authorCAMARA, Niels Olsen Saraiva
dc.contributor.authorOLIVEIRA-SOUZA, Maria
dc.date.accessioned2024-02-15T14:53:21Z
dc.date.available2024-02-15T14:53:21Z
dc.date.issued2023
dc.description.abstractFocal segmental glomerulosclerosis (FSGS) is the leading cause of nephrotic syndrome, which is characterized by podocyte injury. Given that the pathophysiology of nondiabetic glomerulosclerosis is poorly understood and targeted therapies to prevent glomerular disease are lacking, we decided to investigate the tight junction protein claudin-1 and the histone deacetylase sirtuin-1 (SIRT1), which are known to be involved in podocyte injury. For this purpose, we first examined SIRT1, claudin-1 and podocin expression in kidney biopsies from patients diagnosed with nondiabetic FSGS and found that upregulation of glomerular claudin-1 accompanies a significant reduction in glomerular SIRT1 and podocin levels. From this, we investigated whether a small molecule activator of SIRT1, SRT1720, could delay the onset of FSGS in an animal model of adriamycin (ADR)-induced nephropathy; 14 days of treatment with SRT1720 attenuated glomerulosclerosis progression and albuminuria, prevented transcription factor Wilms tumor 1 (WT1) downregulation and increased glomerular claudin-1 in the ADR + SRT1720 group. Thus, we evaluated the effect of ADR and/or SRT1720 in cultured mouse podocytes. The results showed that ADR [1 mu M] triggered an increase in claudin-1 expression after 30 min, and this effect was attenuated by pretreatment of podocytes with SRT1720 [5 mu M]. ADR [1 mu M] also led to changes in the localization of SIRT1 and claudin-1 in these cells, which could be associated with podocyte injury. Although the use of specific agonists such as SRT1720 presents some benefits in glomerular function, their underlying mechanisms still need to be further explored for therapeutic use. Taken together, our data indicate that SIRT1 and claudin-1 are relevant for the pathophysiology of nondiabetic FSGS.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP)
dc.identifier.citationSCIENTIFIC REPORTS, v.13, n.1, article ID 22685, 14p, 2023
dc.identifier.doi10.1038/s41598-023-49861-0
dc.identifier.issn2045-2322
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/58050
dc.language.isoeng
dc.publisherNATURE PORTFOLIOeng
dc.relation.ispartofScientific Reports
dc.rightsopenAccesseng
dc.rights.holderCopyright NATURE PORTFOLIOeng
dc.subject.otherparietal epithelial-cellseng
dc.subject.otherpodocyte injuryeng
dc.subject.otheradriamycin nephropathyeng
dc.subject.otheroxidative stresseng
dc.subject.otheractivationeng
dc.subject.otherapoptosiseng
dc.subject.otherexpressioneng
dc.subject.otherprotectseng
dc.subject.otherhealtheng
dc.subject.othermiceeng
dc.subject.wosMultidisciplinary Scienceseng
dc.titleEvaluation of glomerular sirtuin-1 and claudin-1 in the pathophysiology of nondiabetic focal segmental glomerulosclerosiseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalLOPES-GONCALVES, Guilherme:Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Lab Renal Physiol, 1524 Prof Lineu Prestes Ave, BR-05508000 Sao Paulo, Brazil
hcfmusp.author.externalCOSTA-PESSOA, Juliana Martins:Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Lab Renal Physiol, 1524 Prof Lineu Prestes Ave, BR-05508000 Sao Paulo, Brazil
hcfmusp.author.externalTOSTES, Ana Flavia:Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Lab Neurobiol, Sao Paulo, Brazil
hcfmusp.author.externalSILVA, Eloisa Martins da:Univ Fed Sao Paulo, Paulista Sch Med, Dept Nephrol, Sao Paulo, Brazil
hcfmusp.author.externalTHIEME, Karina:Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Lab Cellular & Mol Bases Renal Physiol, Sao Paulo, Brazil
hcfmusp.author.externalCAMARA, Niels Olsen Saraiva:Univ Fed Sao Paulo, Paulista Sch Med, Dept Nephrol, Sao Paulo, Brazil; Univ Sao Paulo, Inst Biomed Sci, Dept Immunol & Biophys, Lab Transplantat Immunobiol, Sao Paulo, Brazil
hcfmusp.author.externalOLIVEIRA-SOUZA, Maria:Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Lab Renal Physiol, 1524 Prof Lineu Prestes Ave, BR-05508000 Sao Paulo, Brazil
hcfmusp.citation.scopus1
hcfmusp.contributor.author-fmusphcRUAN CESAR APARECIDO PIMENTA
hcfmusp.contributor.author-fmusphcFELIPE LOURENCO LEDESMA
hcfmusp.contributor.author-fmusphcDENISE MARIA AVANCINI COSTA MALHEIROS
hcfmusp.contributor.author-fmusphcROBERTO ZATZ
hcfmusp.description.articlenumber22685
hcfmusp.description.issue1
hcfmusp.description.volume13
hcfmusp.origemWOS
hcfmusp.origem.pubmed38114708
hcfmusp.origem.scopus2-s2.0-85180217369
hcfmusp.origem.wosWOS:001132995200038
hcfmusp.publisher.cityBERLINeng
hcfmusp.publisher.countryGERMANYeng
hcfmusp.relation.referenceAl-Sadi RM, 2007, J IMMUNOL, V178, P4641, DOI 10.4049/jimmunol.178.7.4641eng
hcfmusp.relation.reference[Anonymous], 2021, KIDNEY INT, V99, pS26, DOI 10.1016/j.kint.2020.11.003eng
hcfmusp.relation.referenceBlaine J, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9071700eng
hcfmusp.relation.referenceBryant C, 2022, FRONT CELL DEV BIOL, V10, DOI 10.3389/fcell.2022.924751eng
hcfmusp.relation.referenceCardoso VG, 2018, BMC NEPHROL, V19, DOI 10.1186/s12882-018-0968-4eng
hcfmusp.relation.referenceChang JW, 2016, NEPHRON, V133, P116, DOI 10.1159/000447067eng
hcfmusp.relation.referenceChen ZY, 2017, ONCOTARGET, V8, P88792, DOI 10.18632/oncotarget.21287eng
hcfmusp.relation.referenceDarouich S, 2011, ULTRASTRUCT PATHOL, V35, P176, DOI 10.3109/01913123.2011.584657eng
hcfmusp.relation.referencede Ponte MC, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-97839-7eng
hcfmusp.relation.referenceDe Vriese AS, 2021, NAT REV NEPHROL, V17, P619, DOI 10.1038/s41581-021-00427-1eng
hcfmusp.relation.referenceDe Vriese AS, 2018, J AM SOC NEPHROL, V29, P759, DOI 10.1681/ASN.2017090958eng
hcfmusp.relation.referenceDong YJ, 2014, J DIABETES RES, V2014, DOI 10.1155/2014/843786eng
hcfmusp.relation.referenceElhefnawy N. G., 2019, J. Nephropathol., V8, P1eng
hcfmusp.relation.referenceFeige JN, 2008, CELL METAB, V8, P347, DOI 10.1016/j.cmet.2008.08.017eng
hcfmusp.relation.referenceFogo AB, 2015, NAT REV NEPHROL, V11, P76, DOI 10.1038/nrneph.2014.216eng
hcfmusp.relation.referenceFrench AD, 2009, INT J MED SCI, V6, P93eng
hcfmusp.relation.referenceFunk JA, 2010, J PHARMACOL EXP THER, V333, P593, DOI 10.1124/jpet.109.161992eng
hcfmusp.relation.referenceGonçalves GL, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-36933-9eng
hcfmusp.relation.referenceGong YF, 2017, J AM SOC NEPHROL, V28, P106, DOI 10.1681/ASN.2015121324eng
hcfmusp.relation.referenceGuo JC, 2008, J AM SOC NEPHROL, V19, P961, DOI 10.1681/ASN.2007101109eng
hcfmusp.relation.referenceHan WX, 2019, J ENDOCRINOL, V241, P85, DOI 10.1530/JOE-18-0536eng
hcfmusp.relation.referenceHasegawa K, 2008, BIOCHEM BIOPH RES CO, V372, P51, DOI 10.1016/j.bbrc.2008.04.176eng
hcfmusp.relation.referenceHasegawa K, 2019, CLIN EXP NEPHROL, V23, P987, DOI 10.1007/s10157-019-01719-4eng
hcfmusp.relation.referenceHasegawa K, 2013, NAT MED, V19, P1496, DOI 10.1038/nm.3363eng
hcfmusp.relation.referenceHong Q, 2018, KIDNEY INT, V93, P1330, DOI 10.1016/j.kint.2017.12.008eng
hcfmusp.relation.referenceIida M, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0265081eng
hcfmusp.relation.referenceKang YS, 2010, KIDNEY INT, V78, P363, DOI 10.1038/ki.2010.137eng
hcfmusp.relation.referenceKim H, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18020305eng
hcfmusp.relation.referenceKirk A, 2010, NEPHROL DIAL TRANSPL, V25, P2107, DOI 10.1093/ndt/gfq006eng
hcfmusp.relation.referenceKönigshausen E, 2016, BIOMED RES INT, V2016, DOI 10.1155/2016/3765608eng
hcfmusp.relation.referenceKong LL, 2015, MOL MED, V21, DOI 10.2119/molmed.2014.00211eng
hcfmusp.relation.referenceLee DBN, 2006, AM J PHYSIOL-RENAL, V290, pF20, DOI 10.1152/ajprenal.00052.2005eng
hcfmusp.relation.referenceLee VWS, 2011, NEPHROLOGY, V16, P30, DOI 10.1111/j.1440-1797.2010.01383.xeng
hcfmusp.relation.referenceLi F, 2022, KIDNEY INT, V102, P121, DOI 10.1016/j.kint.2022.02.037eng
hcfmusp.relation.referenceLi GB, 2021, CELL PHYSIOL BIOCHEM, V55, P13, DOI 10.33594/000000356eng
hcfmusp.relation.referenceLi JH, 2011, PEDIATR NEPHROL, V26, P2133, DOI 10.1007/s00467-011-1824-yeng
hcfmusp.relation.referenceLyu L, 2018, CHINESE MED J-PEKING, V131, P2743, DOI 10.4103/0366-6999.245266eng
hcfmusp.relation.referenceCasare FAM, 2016, AM J PHYSIOL-RENAL, V310, pF1295, DOI 10.1152/ajprenal.00471.2015eng
hcfmusp.relation.referenceMaria-Ferreira D, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-30526-2eng
hcfmusp.relation.referenceMitchell SJ, 2014, CELL REP, V6, P836, DOI 10.1016/j.celrep.2014.01.031eng
hcfmusp.relation.referenceMori K, 2011, KIDNEY INT, V79, P1274, DOI 10.1038/ki.2011.36eng
hcfmusp.relation.referenceMorigi M, 2018, J AM SOC NEPHROL, V29, P1799, DOI 10.1681/ASN.2017111218eng
hcfmusp.relation.referenceMundel P, 1997, EXP CELL RES, V236, P248, DOI 10.1006/excr.1997.3739eng
hcfmusp.relation.referenceMusiala A, 2022, J CLIN MED, V11, DOI 10.3390/jcm11123292eng
hcfmusp.relation.referenceNihalani D, 2013, NAT MED, V19, P1371, DOI 10.1038/nm.3386eng
hcfmusp.relation.referenceNishizono R, 2017, J AM SOC NEPHROL, V28, P2931, DOI 10.1681/ASN.2017020174eng
hcfmusp.relation.referenceOhse T, 2009, AM J PHYSIOL-RENAL, V297, pF1566, DOI 10.1152/ajprenal.00214.2009eng
hcfmusp.relation.referenceOzeki T, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0244677eng
hcfmusp.relation.referencePonnusamy M, 2015, J PHARMACOL EXP THER, V354, P142, DOI 10.1124/jpet.115.224386eng
hcfmusp.relation.referenceRosenberg AZ, 2017, CLIN J AM SOC NEPHRO, V12, P502, DOI 10.2215/CJN.05960616eng
hcfmusp.relation.referenceSAITO T, 1987, KIDNEY INT, V32, P691, DOI 10.1038/ki.1987.262eng
hcfmusp.relation.referenceSaurus P, 2015, CELL DEATH DIS, V6, DOI 10.1038/cddis.2015.125eng
hcfmusp.relation.referenceSladojevic N, 2019, J NEUROSCI, V39, P743, DOI 10.1523/JNEUROSCI.1432-18.2018eng
hcfmusp.relation.referenceSmeets B, 2014, AM J PATHOL, V184, P3239, DOI 10.1016/j.ajpath.2014.08.007eng
hcfmusp.relation.referenceSun K, 2021, KIDNEY DIS-BASEL, V7, P350, DOI 10.1159/000517108eng
hcfmusp.relation.referenceSung JY, 2020, FEBS OPEN BIO, V10, P1316, DOI 10.1002/2211-5463.12895eng
hcfmusp.relation.referenceVivarelli M, 2017, CLIN J AM SOC NEPHRO, V12, P332, DOI 10.2215/CJN.05000516eng
hcfmusp.relation.referenceWang K, 2020, PROSTATE, V80, P1203, DOI 10.1002/pros.24046eng
hcfmusp.relation.referenceWang XL, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-018-36911-1eng
hcfmusp.relation.referenceWang Y, 2000, KIDNEY INT, V58, P1797, DOI 10.1046/j.1523-1755.2000.00342.xeng
hcfmusp.relation.referenceWei J, 2015, ARTHRITIS RHEUMATOL, V67, P1323, DOI 10.1002/art.39061eng
hcfmusp.relation.referenceYanagisawa S, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0193921eng
hcfmusp.relation.referenceYang SY, 2016, SCI REP-UK, V6, DOI 10.1038/srep32787eng
hcfmusp.relation.referenceYeung F, 2004, EMBO J, V23, P2369, DOI 10.1038/sj.emboj.7600244eng
hcfmusp.relation.referenceYi MX, 2017, AM J PHYSIOL-RENAL, V313, pF74, DOI 10.1152/ajprenal.00114.2017eng
hcfmusp.relation.referenceZhang JN, 2019, BRIT J PHARMACOL, V176, P4558, DOI 10.1111/bph.14822eng
hcfmusp.relation.referenceZhang T, 2019, MED SCI MONITOR, V25, P1220, DOI 10.12659/MSM.911714eng
hcfmusp.relation.referenceZhong JY, 2019, J HISTOCHEM CYTOCHEM, V67, P623, DOI 10.1369/0022155419850170eng
hcfmusp.relation.referenceZhong YF, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00624eng
hcfmusp.relation.referenceZhou LL, 2015, NAT REV NEPHROL, V11, P535, DOI 10.1038/nrneph.2015.88eng
hcfmusp.relation.referenceZhou LL, 2015, J AM SOC NEPHROL, V26, P677, DOI 10.1681/ASN.2013101067eng
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