Activated Wnt signaling pathway is not influenced by absence of galectin-3 in mice during tongue malignant transformation

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSOUZA, M. V. R.
dc.contributor.authorCHAMMAS, R.
dc.contributor.authorSANT'ANA, J. M. A.
dc.contributor.authorLOYOLA, A. M.
dc.contributor.authorCARDOSO, S. V.
dc.contributor.authorFARIA, P. R.
dc.date.accessioned2013-10-11T21:18:22Z
dc.date.available2013-10-11T21:18:22Z
dc.date.issued2012
dc.description.abstractIntroduction: Oncogenic role for galectin-3 (GAL3) is due to its involvement in the Wnt signaling. Altered expression of Wnt-target proteins like cyclin D1 and APC promote malignant transformation. However, no study has hitherto showed whether GAL3 interferes in the expression of both proteins during oral carcinogenesis. This study reports cyclin D1 and APC expression in dysplasias and carcinomas induced in the tongue of galectin-3 deficient (GAL3)/)) and wild-type (GAL3+/+) mice. Material and Methods: Sixty GAL3)/) and GAL3 +/+ mice were treated with 4NQO for 16 weeks and killed at week 16 and week 32. The tongues were removed and processed for paraffin embedding. Sections were stained with Haematoxylin and Eosin to identify dysplasias and carcinomas. An immunohistochemical assay was applied to evaluate the expression of cyclin D1 and APC protein. Results: Oral carcinogenesis occurred in both groups (P> 0.05). In GAL3)/) mice, the percentage of cyclin D1-positive cells was 36% for both dysplasias and carcinomas; in GAL3 +/+ mice, it was 28% and 34%, respectively. The intensity of APC expression in dysplasias from GAL3)/) mice ranged from weak (31.7%), moderate (12.2%) to strong (2.4%); in carcinomas from the same group, 48.1% and 7.4% of cases respectively exhibited a weak and moderate expression. In GAL3 +/+ mice, 59.4% and 28.1% of dysplasias and 50% and 40% of carcinomas presented a weak and moderate APC expression, respectively. However, no statistical significance was found. Conclusion: The absence of GAL3 does not interfere in the oral carcinogenesis and activated Wnt signaling was observed in both groups of mice (FAPEMIG).
dc.description.conferencedateSEP 30-OCT 05, 2012
dc.description.conferencelocalCape Town, SOUTH AFRICA
dc.description.conferencename29th Congress of the International-Academy-of-Pathology
dc.description.indexMEDLINE
dc.identifier.citationHISTOPATHOLOGY, v.61, suppl.1, Special Issue, p.131-131, 2012
dc.identifier.issn0309-0167
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/2844
dc.language.isoeng
dc.publisherWILEY-BLACKWELL
dc.relation.ispartofHistopathology
dc.rightsrestrictedAccess
dc.rights.holderCopyright WILEY-BLACKWELL
dc.subject.wosCell Biology
dc.subject.wosPathology
dc.titleActivated Wnt signaling pathway is not influenced by absence of galectin-3 in mice during tongue malignant transformation
dc.typeconferenceObject
dc.type.categorymeeting abstract
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalSOUZA, M. V. R.:Univ Fed Uberlandia, Fac Med, Uberlandia, MG, Brazil
hcfmusp.author.externalSANT'ANA, J. M. A.:Univ Fed Uberlandia, Master Program, Uberlandia, MG, Brazil
hcfmusp.author.externalLOYOLA, A. M.:Univ Fed Uberlandia, Fac Odontol, Uberlandia, MG, Brazil
hcfmusp.author.externalCARDOSO, S. V.:Univ Fed Uberlandia, Fac Odontol, Uberlandia, MG, Brazil
hcfmusp.author.externalFARIA, P. R.:Univ Fed Uberlandia, Inst Ciencias Biomed, Uberlandia, MG, Brazil
hcfmusp.contributor.author-fmusphcROGER CHAMMAS
hcfmusp.description.beginpage131
hcfmusp.description.endpage131
hcfmusp.description.issuesuppl 1
hcfmusp.description.issueSpecial Issue
hcfmusp.description.volume61
hcfmusp.origemWOS
hcfmusp.origem.wosWOS:000308126900379
hcfmusp.publisher.cityHOBOKEN
hcfmusp.publisher.countryUSA
relation.isAuthorOfPublication1fdeabdc-849e-48e4-ba52-1c124a06b220
relation.isAuthorOfPublication.latestForDiscovery1fdeabdc-849e-48e4-ba52-1c124a06b220
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