The influence of hydroxyurea on oxidative stress in sickle cell anemia

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art_RUIZ_The_influence_of_hydroxyurea_on_oxidative_stress_in_2012.PDF (600.07 KB)
Citações na Scopus
27
Tipo de produção
article
Data de publicação
2012
DOI
SciELO
Scopus
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
Associação Brasileira de Hematologia e Hemoterapia e da
Autores
TORRES, Lidiane de Souza
SILVA, Danilo Grünig Humberto da
BELINI JUNIOR, Edis
ALMEIDA, Eduardo Alves de
LOBO, Clarisse Lopes de Castro
CANÇADO, Rodolfo Delfini
BONINI-DOMINGOS, Claudia Regina
Citação
REVISTA BRASILEIRA DE HEMATOLOGIA E HEMOTERAPIA, v.34, n.6, p.421-425, 2012
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
OBJECTIVE: The oxidative stress in 20 sickle cell anemia patients taking hydroxyurea and 13 sickle cell anemia patients who did not take hydroxyurea was compared with a control group of 96 individuals without any hemoglobinopathy. METHODS: Oxidative stress was assessed by thiobarbituric acid reactive species production, the Trolox-equivalent antioxidant capacity and plasma glutathione levels. RESULTS: Thiobarbituric acid reactive species values were higher in patients without specific medication, followed by patients taking hydroxyurea and the Control Group (p < 0.0001). The antioxidant capacity was higher in patients taking hydroxyurea and lower in the Control Group (p = 0.0002 for Trolox-equivalent antioxidant capacity and p < 0.0292 for plasma glutathione). Thiobarbituric acid reactive species levels were correlated with higher hemoglobin S levels (r = 0.55; p = 0.0040) and lower hemoglobin F concentrations(r = -0.52; p = 0.0067). On the other hand, plasma glutathione levels were negatively correlated with hemoglobin S levels (r = -0.49; p = 0.0111) and positively associated with hemoglobin F values (r = 0.56; p = 0.0031). CONCLUSION: Sickle cell anemia patients have high oxidative stress and, conversely, increased antioxidant activity. The increase in hemoglobin F levels provided by hydroxyurea and its antioxidant action may explain the reduction in lipid peroxidation and increased antioxidant defenses in these individuals.
Palavras-chave
Hemoglobinopathies, Oxidative stress, Anemia, sickle cell, Hydroxyurea
URI
https://observatorio.fm.usp.br/handle/OPI/5943
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Coleções
Artigos e Materiais de Revistas Científicas - FM/Outros
Artigos e Materiais de Revistas Científicas - HC/InCor