Networks of Neurodevelopmental Traits, Socioenvironmental Factors, Emotional Dysregulation in Childhood, and Depressive Symptoms Across Development in Two UK Cohorts

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorFARHAT, Luis C.
dc.contributor.authorBLAKEY, Rachel
dc.contributor.authorSMITH, George Davey
dc.contributor.authorFUJITA, Andre
dc.contributor.authorSHEPHARD, Elizabeth
dc.contributor.authorSTERGIAKOULI, Evie
dc.contributor.authorELEY, Thalia C.
dc.contributor.authorTHAPAR, Anita
dc.contributor.authorPOLANCZYK, Guilherme V.
dc.date.accessioned2024-04-05T19:35:04Z
dc.date.available2024-04-05T19:35:04Z
dc.date.issued2023
dc.description.abstractObjective: Previous population-based studies have identified associations between childhood neurodevelopmental traits and depression in childhood, adolescence, and young adulthood. However, neurodevelopmental traits are highly correlated with each other, which could confound associations when traits are examined in isolation. The authors sought to identify unique associations between multiple neurodevelopmental traits in childhood and depressive symptoms across development, while taking into account co-occurring difficulties, in multivariate analyses. Methods: Data from two U.K. population-based cohorts, the Twins Early Development Study (TEDS) (N=4,407 independent twins) and the Avon Longitudinal Study of Parents and Children (ALSPAC) (N=10,351), were independently analyzed. Bayesian Gaussian graphical models were estimated to investigate pairwise conditional associations between neurodevelopmental traits (autism and ADHD symptoms and general cognitive, learning, and communication abilities), socioenvironmental stressors (academic performance and peer relations), and emotional dysregulation in childhood (ages 7-11) and depressive symptoms across development (ages 12, 16, and 21). Results: In both cohorts, bivariate correlations indicated several associations between neurodevelopmental traits and depressive symptoms across development. However, based on replicated findings across cohorts, these pairs of variables were mostly conditionally independent, and none were conditionally associated, after accounting for socioenvironmental stressors and emotional dysregulation. In turn, socioenvironmental stressors and emotional dysregulation were conditionally associated with both neurodevelopmental traits and depressive symptoms. Based on replicated findings across cohorts, neurodevelopmental traits in childhood could be associated only indirectly with depressive symptoms across development. Conclusions: This study indicates that associations between childhood neurodevelopmental traits and depressive symptoms across development could be explained by socioenvironmental stressors and emotional dysregulation. The present findings could inform future research aimed at the prevention of depression in youths with neurodevelopmental disorders.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexScopus
dc.description.indexDimensions
dc.description.indexWoS
dc.description.sponsorshipSao Paulo Research Foundation [2020/05964-1]
dc.description.sponsorshipWellcome Trust [204895/Z/16/Z]
dc.description.sponsorshipUniversity of Bristol
dc.description.sponsorshipU.K. Medical Research Council [MC_UU_00011/1]
dc.identifier.citationAMERICAN JOURNAL OF PSYCHIATRY, v.180, n.10, p.755-765, 2023
dc.identifier.doi10.1176/appi.ajp.20220868
dc.identifier.eissn1535-7228
dc.identifier.issn0002-953X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/58998
dc.language.isoeng
dc.publisherAMER PSYCHIATRIC PUBLISHING, INCeng
dc.relation.ispartofAmerican Journal of Psychiatry
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright AMER PSYCHIATRIC PUBLISHING, INCeng
dc.subject.otheradhdeng
dc.subject.otherchildreneng
dc.subject.otherriskeng
dc.subject.otherdifficultieseng
dc.subject.otheradolescenteng
dc.subject.othermediationeng
dc.subject.otheradultseng
dc.subject.otheronseteng
dc.subject.wosPsychiatryeng
dc.titleNetworks of Neurodevelopmental Traits, Socioenvironmental Factors, Emotional Dysregulation in Childhood, and Depressive Symptoms Across Development in Two UK Cohortseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryPaís de Gales
hcfmusp.affiliation.countryInglaterra
hcfmusp.affiliation.countryisogb
hcfmusp.author.externalBLAKEY, Rachel:Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, Avon, England; Univ Bristol, Dept Populat Hlth Sci, Bristol Med Sch, Bristol, Avon, England
hcfmusp.author.externalSMITH, George Davey:Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, Avon, England; Univ Bristol, Dept Populat Hlth Sci, Bristol Med Sch, Bristol, Avon, England
hcfmusp.author.externalFUJITA, Andre:Univ Sao Paulo, Inst Matemat & Estatist, Dept Comp Sci, Sao Paulo, Brazil
hcfmusp.author.externalSTERGIAKOULI, Evie:Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, Avon, England; Univ Bristol, Dept Populat Hlth Sci, Bristol Med Sch, Bristol, Avon, England
hcfmusp.author.externalELEY, Thalia C.:Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England
hcfmusp.author.externalTHAPAR, Anita:Cardiff Univ, Sch Med, Wolfson Ctr Young Peoples Mental Hlth, Cardiff, Wales; Cardiff Univ, Div Psychol Med, Child & Adolescent Psychiat Sect, Sch Med, Cardiff, Wales
hcfmusp.citation.scopus1
hcfmusp.contributor.author-fmusphcLUIS CARLOS FARHAT
hcfmusp.contributor.author-fmusphcELIZABETH SHEPHARD
hcfmusp.contributor.author-fmusphcGUILHERME VANONI POLANCZYK
hcfmusp.description.beginpage755
hcfmusp.description.endpage765
hcfmusp.description.issue10
hcfmusp.description.volume180
hcfmusp.origemWOS
hcfmusp.origem.dimensionspub.1163321998
hcfmusp.origem.pubmed37583326
hcfmusp.origem.scopus2-s2.0-85172941306
hcfmusp.origem.wosWOS:001167936600009
hcfmusp.publisher.cityWASHINGTONeng
hcfmusp.publisher.countryUSAeng
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