Microbial Translocation Induces an Intense Proinflammatory Response in PatientsWith Visceral Leishmaniasis and HIV Type 1 Coinfection

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSANTOS-OLIVEIRA, Joanna R.
dc.contributor.authorREGIS, Eduardo G.
dc.contributor.authorGIACOIA-GRIPP, Carmem B. W.
dc.contributor.authorVALVERDE, Joanna G.
dc.contributor.authorALEXANDRINO-DE-OLIVEIRA, Priscilla
dc.contributor.authorLINDOSO, Jose Angelo L.
dc.contributor.authorGOTO, Hiro
dc.contributor.authorOLIVEIRA-NETO, Manoel P.
dc.contributor.authorGUERRA, Jorge O.
dc.contributor.authorGRINSZTEJN, Beatriz
dc.contributor.authorJERONIMO, Selma B.
dc.contributor.authorMORGADO, Mariza G.
dc.contributor.authorDA-CRUZ, Alda M.
dc.date.accessioned2013-09-23T16:43:50Z
dc.date.available2013-09-23T16:43:50Z
dc.date.issued2013
dc.description.abstractBackground. Leishmania infection is a cofactor in the heightened cellular activation observed in patients with American visceral leishmaniasis and human immunodeficiency virus type 1 (HIV) infection, with or without progression to AIDS (AVL/HIV). Thus, the persistence of a high parasite load despite antileishmanial therapy could be responsible for the continued immune stimulation. Methods. CD8(+) T cells expressing CD38, parasite load, lipopolysaccharide (LPS), soluble CD14, macrophage migration inhibitory factor (MIF), intestinal fatty acid-binding protein (IFABP), and proinflammatory cytokines (interleukin 1 beta, interleukin 6, interleukin 8, interleukin 17, interferon gamma, and tumor necrosis factor) were measured in 17 patients with AVL/HIV, 16 with HIV, and 14 healthy subjects (HS). Results. Lower Leishmania parasitemia was observed after antileishmanial and antiretroviral therapies. However, higher levels of CD38(+) on CD8(+) T cells were observed in both clinical phases of leishmaniasis, compared with HIV cases. AVL/HIV and HIV patients showed higher levels of LPS and IFABP than HS. Proinflammatory cytokine levels were significantly augmented in patients with active coinfection, as well as those with remission of Leishmania infection. LPS levels and Leishmania infection were positively correlated with CD38 expression on CD8(+) T cells and with IL-6 and IL-8 levels. Conclusions. LPS levels along with the immune consequences of Leishmania infection were associated with elevated cellular activation in coinfected patients. As a consequence, secondary chemoprophylaxis for leishmaniasis or even the use of antiinflammatory drugs or antibiotics may be considered for improving the prognosis of AVL/HIV.
dc.description.indexMEDLINE
dc.description.sponsorshipPrograma Nacional de DST/AIDS, Ministerio da Saude [ED00095/2007]
dc.description.sponsorshipInstituto Oswaldo Cruz
dc.description.sponsorshipFAPERJ [FAPERJ nota 10]
dc.description.sponsorshipCNPq
dc.identifier.citationJOURNAL OF INFECTIOUS DISEASES, v.208, n.1, p.57-66, 2013
dc.identifier.doi10.1093/infdis/jit135
dc.identifier.issn0022-1899
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/2117
dc.language.isoeng
dc.publisherOXFORD UNIV PRESS INC
dc.relation.ispartofJournal of Infectious Diseases
dc.rightsrestrictedAccess
dc.rights.holderCopyright OXFORD UNIV PRESS INC
dc.subjectvisceral leishmaniasis-HIV/AIDS coinfection
dc.subjectmicrobial translocation
dc.subjectinflammatory cytokines
dc.subject.othert-cells
dc.subject.otherimmune activation
dc.subject.othergastrointestinal-tract
dc.subject.otherinfected patients
dc.subject.otherkala-azar
dc.subject.otherdisease
dc.subject.othervirus
dc.subject.othercytokines
dc.subject.otheraids
dc.subject.otherreplication
dc.subject.wosImmunology
dc.subject.wosInfectious Diseases
dc.subject.wosMicrobiology
dc.titleMicrobial Translocation Induces an Intense Proinflammatory Response in PatientsWith Visceral Leishmaniasis and HIV Type 1 Coinfection
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalSANTOS-OLIVEIRA, Joanna R.:Fiocruz MS, Inst Oswaldo Cruz, Lab Interdisciplinar Pesquisas Med, BR-21045900 Rio De Janeiro, RJ, Brazil
hcfmusp.author.externalREGIS, Eduardo G.:Fiocruz MS, Inst Oswaldo Cruz, Lab Pesquisa Timo, BR-21045900 Rio De Janeiro, RJ, Brazil
hcfmusp.author.externalGIACOIA-GRIPP, Carmem B. W.:Fiocruz MS, Inst Oswaldo Cruz, Lab Aids & Imunol Mol, BR-21045900 Rio De Janeiro, RJ, Brazil
hcfmusp.author.externalVALVERDE, Joanna G.:Univ Fed Rio Grande do Norte, Dept Bioquim, BR-59072970 Natal, RN, Brazil
hcfmusp.author.externalALEXANDRINO-DE-OLIVEIRA, Priscilla:Univ Fed Mato Grosso do Sul, Univ Hosp, Hosp Dia Profa Esterina Corsini, Campo Grande, Brazil
hcfmusp.author.externalOLIVEIRA-NETO, Manoel P.:Fiocruz MS, IPEC, Inst Pesquisa Clin Evandro Chagas, BR-21045900 Rio De Janeiro, RJ, Brazil
hcfmusp.author.externalGUERRA, Jorge O.:Fundacao Med Trop Dr Heitor Vieira Dourado, Manaus, Amazonas, Brazil
hcfmusp.author.externalGRINSZTEJN, Beatriz:Fiocruz MS, IPEC, Inst Pesquisa Clin Evandro Chagas, BR-21045900 Rio De Janeiro, RJ, Brazil
hcfmusp.author.externalJERONIMO, Selma B.:Univ Fed Rio Grande do Norte, Dept Bioquim, BR-59072970 Natal, RN, Brazil
hcfmusp.author.externalMORGADO, Mariza G.:Fiocruz MS, Inst Oswaldo Cruz, Lab Aids & Imunol Mol, BR-21045900 Rio De Janeiro, RJ, Brazil
hcfmusp.author.externalDA-CRUZ, Alda M.:Fiocruz MS, Inst Oswaldo Cruz, Lab Interdisciplinar Pesquisas Med, BR-21045900 Rio De Janeiro, RJ, Brazil; Univ Estado Rio de Janeiro, Fac Ciencias Med, Disciplina Parasitol, Rio De Janeiro, Brazil
hcfmusp.citation.scopus32
hcfmusp.contributor.author-fmusphcJOSE ANGELO LAULETTA LINDOSO
hcfmusp.contributor.author-fmusphcHIRO GOTO
hcfmusp.description.beginpage57
hcfmusp.description.endpage66
hcfmusp.description.issue1
hcfmusp.description.volume208
hcfmusp.origemWOS
hcfmusp.origem.pubmed23539743
hcfmusp.origem.scopus2-s2.0-84878611218
hcfmusp.origem.wosWOS:000319830300010
hcfmusp.publisher.cityCARY
hcfmusp.publisher.countryUSA
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hcfmusp.remissive.sponsorshipCNPq
hcfmusp.remissive.sponsorshipFAPERJ
hcfmusp.remissive.sponsorshipMinistério da Saúde
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