Evolution of Biomarkers of Atherogenic Risk in Liver Transplantation Recipients

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLINHARES, L. M. C.
dc.contributor.authorOLIVEIRA, C. P.
dc.contributor.authorALVARES-DA-SILVA, M. R.
dc.contributor.authorSTEFANO, J. T.
dc.contributor.authorBARBEIRO, H. V.
dc.contributor.authorBARBEIRO, D. F.
dc.contributor.authorTERRABUIO, D. R. B.
dc.contributor.authorABDALA, E.
dc.contributor.authorSORIANO, F. G.
dc.contributor.authorCARRILHO, F. J.
dc.contributor.authorFARIAS, A. Q.
dc.contributor.authorSIDDIQUI, M. S.
dc.contributor.authorD'ALBUQUERQUE, L. A. C.
dc.date.accessioned2019-02-21T17:24:15Z
dc.date.available2019-02-21T17:24:15Z
dc.date.issued2018
dc.description.abstractBackground. Cardiovascular disease is a major contributing factor to long-term mortality after liver transplantation (LT). Methods. This study evaluated the evolution of atherogenic risk in liver transplant recipients (LTRs). Thirty-six subjects were prospectively enrolled at 12 months and followed for 48 months after liver transplantation. Serum biomarkers of endothelial dysfunction (sICAM-1 and sVCAM-1), chronic inflammation (serum amyloid A), and oxidative stress (myeloperoxidase) were measured at 12 and 48 months after LT. Additionally, at 12 months all patients underwent a cardiac computed tomography (CT) scan and a coronary artery calcium score (CACS). Results. The prevalence of risk factors of metabolic syndrome (MS) increased over the course of the study. The patients' sVCAM-1 and sICAM-1 increased from 1.82 +/- 0.44 ng/mL to 9.10 +/- 5.82 ng/mL (P < .001) and 0.23 +/- 0.09 ng/mL to 2.7 +/- 3.3 ng/mL, respectively from month 12 to 48. Serum myeloperoxidase increased from 0.09 +/- 0.07 ng/mL to 3.46 +/- 3.92 ng/mL (P < .001) over the course of the study. Serum amyloid A also increased from 21.4 +/- 40.7 ng/mL at entry to 91.5 +/- 143.6 ng/mL at end of study (P < .001). Conclusion. No association between these biomarkers and MS was noted. The cardiac CT revealed mild and moderate disease in 19% and 25% of the cohort, respectively. No association between serum biomarkers and CACS was noted. Serum biomarkers of atherogenic risk increase rapidly in LTRs and precede coronary plaques.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipCoordination for the Improvement of Higher Education Personnel at the University of Sao Paulo
dc.identifier.citationTRANSPLANTATION PROCEEDINGS, v.50, n.10, p.3650-3655, 2018
dc.identifier.doi10.1016/j.transproceed.2018.04.030
dc.identifier.eissn1873-2623
dc.identifier.issn0041-1345
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/30850
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INCeng
dc.relation.ispartofTransplantation Proceedings
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright ELSEVIER SCIENCE INCeng
dc.subject.otherc-reactive proteineng
dc.subject.othercomputed-tomographyeng
dc.subject.othermetabolic syndromeeng
dc.subject.otheroutcomeseng
dc.subject.otherquantificationeng
dc.subject.otherassociationeng
dc.subject.otherpredictioneng
dc.subject.othermortalityeng
dc.subject.otherdiseaseeng
dc.subject.wosImmunologyeng
dc.subject.wosSurgeryeng
dc.subject.wosTransplantationeng
dc.titleEvolution of Biomarkers of Atherogenic Risk in Liver Transplantation Recipientseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalALVARES-DA-SILVA, M. R.:Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Div Gastroenterol, Porto Alegre, RS, Brazil
hcfmusp.author.externalSIDDIQUI, M. S.:Virginia Commonwealth Univ, Div Gastroenterol & Hepatol, Med Coll Virginia Campus, Richmond, VA 23284 USA
hcfmusp.citation.scopus6
hcfmusp.contributor.author-fmusphcLIVIA MELO CARONE LINHARES
hcfmusp.contributor.author-fmusphcCLAUDIA PINTO MARQUES SOUZA DE OLIVEIRA
hcfmusp.contributor.author-fmusphcJOSE TADEU STEFANO
hcfmusp.contributor.author-fmusphcHERMES VIEIRA BARBEIRO
hcfmusp.contributor.author-fmusphcDENISE FREDIANI BARBEIRO
hcfmusp.contributor.author-fmusphcDEBORA RAQUEL BENEDITA TERRABUIO
hcfmusp.contributor.author-fmusphcEDSON ABDALA
hcfmusp.contributor.author-fmusphcFRANCISCO GARCIA SORIANO
hcfmusp.contributor.author-fmusphcFLAIR JOSE CARRILHO
hcfmusp.contributor.author-fmusphcALBERTO QUEIROZ FARIAS
hcfmusp.contributor.author-fmusphcLUIZ AUGUSTO CARNEIRO D ALBUQUERQUE
hcfmusp.description.beginpage3650
hcfmusp.description.endpage3655
hcfmusp.description.issue10
hcfmusp.description.volume50
hcfmusp.origemWOS
hcfmusp.origem.pubmed30586839
hcfmusp.origem.scopus2-s2.0-85055567779
hcfmusp.origem.wosWOS:000454972000120
hcfmusp.publisher.cityNEW YORKeng
hcfmusp.publisher.countryUSAeng
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hcfmusp.scopus.lastupdate2024-05-10
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