Binding Affinity, Specificity and Comparative Biodistribution of the Parental Murine Monoclonal Antibody MX35 (Anti-NaPi2b) and Its Humanized Version Rebmab200

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLINDEGREN, Sture
dc.contributor.authorANDRADE, Luciana N. S.
dc.contributor.authorBACK, Tom
dc.contributor.authorMACHADO, Camila Maria L.
dc.contributor.authorHORTA, Bruno Brasil
dc.contributor.authorBUCHPIGUEL, Carlos
dc.contributor.authorMORO, Ana Maria
dc.contributor.authorOKAMOTO, Oswaldo Keith
dc.contributor.authorJACOBSSON, Lars
dc.contributor.authorCEDERKRANTZ, Elin
dc.contributor.authorWASHIYAMA, Kohshin
dc.contributor.authorANEHEIM, Emma
dc.contributor.authorPALM, Stig
dc.contributor.authorJENSEN, Holger
dc.contributor.authorTUMA, Maria Carolina B.
dc.contributor.authorCHAMMAS, Roger
dc.contributor.authorHULTBORN, Ragnar
dc.contributor.authorALBERTSSON, Per
dc.date.accessioned2015-08-14T15:35:24Z
dc.date.available2015-08-14T15:35:24Z
dc.date.issued2015
dc.description.abstractThe aim of this preclinical study was to evaluate the characteristics of the monoclonal antibody Rebmab200, which is a humanized version of the ovarian-specific murine antibody MX35. This investigation contributes to the foundation for future clinical alpha-radioimmunotherapy of minimal residual ovarian cancer with At-211-Rebmab200. Here, the biodistribution of 211At-Rebmab200 was evaluated, as was the utility of Tc-99m-Rebmab200 for bioimaging. Rebmab200 was directly compared with its murine counterpart MX35 in terms of its in-vitro capacity for binding the immobilized NaPi2B epitope and live cells; we also assessed its biodistribution in nude mice carrying subcutaneous OVCAR-3 tumors. Tumor antigen and cell binding were similar between Rebmab200 and murine MX35, as was biodistribution, including normal tissue uptake and in-vivo tumor binding. We also demonstrated that Tc-99m-Rebmab200 can be used for single-photon emission computed tomography of subcutaneous ovarian carcinomas in tumor-bearing mice. Taken together, our data support the further development of Rebmab200 for radioimmunotherapy and diagnostics.
dc.description.indexMEDLINE
dc.description.sponsorshipKing Gustaf V Jubilee Clinic Cancer Research Foundation in Gothenburg, Sweden
dc.description.sponsorshipSwedish Cancer Society [2013-642, 2013-644]
dc.description.sponsorshipCNPq in Brasil
dc.description.sponsorshipFINEP, in Brasil
dc.description.sponsorshipRecepta Biopharma
dc.identifier.citationPLOS ONE, v.10, n.5, article ID e0126298, 16p, 2015
dc.identifier.doi10.1371/journal.pone.0126298
dc.identifier.issn1932-6203
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/9748
dc.language.isoeng
dc.publisherPUBLIC LIBRARY SCIENCE
dc.relation.ispartofPlos One
dc.rightsopenAccess
dc.rights.holderCopyright PUBLIC LIBRARY SCIENCE
dc.subject.otherpinhole spect/micro-ct
dc.subject.otherovarian-cancer
dc.subject.othernude-mice
dc.subject.otherradioimmunotherapy
dc.subject.otherefficacy
dc.subject.otherat-211
dc.subject.othermov18
dc.subject.othercells
dc.subject.wosMultidisciplinary Sciences
dc.titleBinding Affinity, Specificity and Comparative Biodistribution of the Parental Murine Monoclonal Antibody MX35 (Anti-NaPi2b) and Its Humanized Version Rebmab200
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countrySuécia
hcfmusp.affiliation.countryDinamarca
hcfmusp.affiliation.countryisose
hcfmusp.affiliation.countryisodk
hcfmusp.author.externalLINDEGREN, Sture:Univ Gothenburg, Sahlgrenska Acad, Dept Radiat Phys, Gothenburg, Sweden
hcfmusp.author.externalBACK, Tom:Univ Gothenburg, Sahlgrenska Acad, Dept Radiat Phys, Gothenburg, Sweden
hcfmusp.author.externalHORTA, Bruno Brasil:Recepta Biopharma, Sao Paulo, Brazil
hcfmusp.author.externalMORO, Ana Maria:Inst Butantan, Lab Biofarmacos Celulas Anim, Sao Paulo, Brazil
hcfmusp.author.externalOKAMOTO, Oswaldo Keith:Recepta Biopharma, Sao Paulo, Brazil; Univ Sao Paulo, Inst Biociencias, Dept Genet & Biol Evolut, Sao Paulo, Brazil
hcfmusp.author.externalJACOBSSON, Lars:Univ Gothenburg, Sahlgrenska Acad, Dept Radiat Phys, Gothenburg, Sweden
hcfmusp.author.externalCEDERKRANTZ, Elin:Univ Gothenburg, Sahlgrenska Acad, Dept Radiat Phys, Gothenburg, Sweden
hcfmusp.author.externalWASHIYAMA, Kohshin:Univ Gothenburg, Sahlgrenska Acad, Dept Radiat Phys, Gothenburg, Sweden
hcfmusp.author.externalANEHEIM, Emma:Univ Gothenburg, Sahlgrenska Acad, Dept Radiat Phys, Gothenburg, Sweden
hcfmusp.author.externalPALM, Stig:Univ Gothenburg, Sahlgrenska Acad, Dept Radiat Phys, Gothenburg, Sweden
hcfmusp.author.externalJENSEN, Holger:Rigshosp, Cyclotron & PET Unit, KF 3982, Copenhagen, Denmark
hcfmusp.author.externalTUMA, Maria Carolina B.:Recepta Biopharma, Sao Paulo, Brazil
hcfmusp.author.externalHULTBORN, Ragnar:Univ Gothenburg, Sahlgrenska Acad, Dept Oncol, Gothenburg, Sweden
hcfmusp.author.externalALBERTSSON, Per:Univ Gothenburg, Sahlgrenska Acad, Dept Oncol, Gothenburg, Sweden
hcfmusp.citation.scopus13
hcfmusp.contributor.author-fmusphcLUCIANA NOGUEIRA DE SOUSA ANDRADE
hcfmusp.contributor.author-fmusphcCAMILA MARIA LONGO MACHADO
hcfmusp.contributor.author-fmusphcCARLOS ALBERTO BUCHPIGUEL
hcfmusp.contributor.author-fmusphcROGER CHAMMAS
hcfmusp.description.articlenumbere0126298
hcfmusp.description.issue5
hcfmusp.description.volume10
hcfmusp.origemWOS
hcfmusp.origem.pubmed25970341
hcfmusp.origem.scopus2-s2.0-84929379768
hcfmusp.origem.wosWOS:000354544200101
hcfmusp.publisher.citySAN FRANCISCO
hcfmusp.publisher.countryUSA
hcfmusp.relation.referenceAndersson H, 2009, J NUCL MED, V50, P1153, DOI 10.2967/jnumed.109.062604
hcfmusp.relation.referenceAndersson H, 2000, ACTA ONCOL, V39, P741
hcfmusp.relation.referenceAndersson H, 2000, ANTICANCER RES, V20, P459
hcfmusp.relation.referenceElgqvist J, 2006, INT J RADIAT ONCOL, V66, P1228, DOI 10.1016/j.ijrobp.2006.07.003
hcfmusp.relation.referenceElgqvist J, 2005, J NUCL MED, V46, P464
hcfmusp.relation.referenceElgqvist J, 2010, J ONCOL, V2010, DOI [10.1155/2010/394913, DOI 10.1155/2010/394913]
hcfmusp.relation.referenceElgqvist J, 2005, J NUCL MED, V46, P1907
hcfmusp.relation.referenceFlook AM, 2013, MOL PHARMACEUT, V10, P3417, DOI 10.1021/mp400248f
hcfmusp.relation.referenceGainkam LOT, 2008, J NUCL MED, V49, P788, DOI 10.2967/jnumed.107.048538
hcfmusp.relation.referenceGoldenberg DM, 2012, THERANOSTICS, V2, P523, DOI 10.7150/thno.3582
hcfmusp.relation.referenceHAMILTON JG, 1950, J CLIN INVEST, V29, P820
hcfmusp.relation.referenceKUUSREICHEL K, 1994, CLIN DIAGN LAB IMMUN, V1, P365
hcfmusp.relation.referenceLeinster DA, 2012, J PATHOL, V227, P136, DOI 10.1002/path.4002
hcfmusp.relation.referenceLindegren S, 2001, APPL RADIAT ISOTOPES, V55, P157, DOI 10.1016/S0969-8043(01)00044-6
hcfmusp.relation.referenceLindegren S, 2008, J NUCL MED, V49, P1537, DOI 10.2967/jnumed.107.049833
hcfmusp.relation.referenceLINDMO T, 1984, J IMMUNOL METHODS, V72, P77, DOI 10.1016/0022-1759(84)90435-6
hcfmusp.relation.referencedos Santos ML, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0070332
hcfmusp.relation.referenceMAHER VE, 1992, J IMMUNOTHER, V11, P56, DOI 10.1097/00002371-199201000-00007
hcfmusp.relation.referenceMalviya G, 2012, MOL IMAGING BIOL, V14, P637, DOI 10.1007/s11307-011-0527-x
hcfmusp.relation.referenceMATTES MJ, 1987, CANCER RES, V47, P6741
hcfmusp.relation.referenceMirick GR, 2004, Q J NUCL MED MOL IM, V48, P251
hcfmusp.relation.referenceVaneycken I, 2010, J NUCL MED, V51, P1099, DOI 10.2967/jnumed.109.069823
hcfmusp.relation.referenceVISSER GWM, 1981, INT J APPL RADIAT IS, V32, P905, DOI 10.1016/0020-708X(81)90077-6
hcfmusp.relation.referenceWu AM, 2014, METHODS, V65, P139, DOI 10.1016/j.ymeth.2013.09.015
hcfmusp.relation.referenceYin Beatrice W T, 2008, Cancer Immun, V8, P3
hcfmusp.relation.referenceZalutsky MR, 2005, J NUCL MED, V46, p151S
hcfmusp.relation.referenceZalutsky MR, 2000, CURR PHARM DESIGN, V6, P1433, DOI 10.2174/1381612003399275
hcfmusp.relation.referenceZalutsky MR, 2008, J NUCL MED, V49, P30, DOI 10.2967/jnumed.107.046938
hcfmusp.relation.referenceZALUTSKY MR, 1987, APPL RADIAT ISOTOPES, V38, P1051
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