Comorbidity, age of onset and suicidality in obsessive-Compulsive disorder (OCD): An international collaboration
Carregando...
Citações na Scopus
149
Tipo de produção
article
Data de publicação
2017
Editora
W B SAUNDERS CO-ELSEVIER INC
Indexadores
Título da Revista
ISSN da Revista
Título do Volume
Métricas da Revista
Autores
BRAKOULIAS, V.
STARCEVIC, V.
BELLOCH, A.
BROWN, C.
FERRAO, Y. A.
FONTENELLE, L. F.
LOCHNER, C.
MARAZZITI, D.
MATSUNAGA, H.
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
COMPREHENSIVE PSYCHIATRY, v.76, p.79-86, 2017
Resumo
Objectives: To collate data from multiple obsessive-compulsive disorder (OCD) treatment centers across seven countries and five continents, and to report findings in relation to OCD comorbidity, age of onset of OCD and comorbid disorders, and suicidality, in a large clinical and ethnically diverse sample, with the aim of investigating cultural variation and the utility of the psychiatric diagnostic classification of obsessive-compulsive and related disorders. Methods: Researchers in the field of OCD were invited to contribute summary statistics on current and lifetime psychiatric comorbidity, age of onset of OCD and comorbid disorders and suicidality in their patients with OCD. Results: Data from 3711 adult patients with primary OCD came from Brazil (n = 955), India (n = 802), Italy (n = 750), South Africa (n = 565), Japan (n = 322), Australia (n = 219), and Spain (n = 98). The most common current comorbid disorders were major depressive disorder (28.4%; n = 1055), obsessive-compulsive personality disorder (24.5%, n = 478), generalized anxiety disorder (19.3%, n = 716), specific phobia (19.2%, n = 714) and social phobia (18.5%, n = 686). Major depression was also the most commonly co-occurring lifetime diagnosis, with a rate of 50.5% (n = 1874). OCD generally had an age of onset in late adolescence (mean = 17.9 years, SD = 1.9). Social phobia, specific phobia and body dysmorphic disorder also had an early age of onset. Co-occurring major depressive disorder, generalized anxiety disorder and psychotic disorders tended to have a later age of onset than OCD. Suicidal ideation within the last month was reported by 6.4% (n = 200) of patients with OCD and 9.0% (n = 314) reported a lifetime history of suicide attempt. Conclusions: In this large cross-continental study, comorbidity in OCD was common. The high rates of comorbid major depression and anxiety disorders emphasize the need for clinicians to assess and monitor for these disorders. Earlier ages of onset of OCD, specific phobia and social phobia may indicate some relatedness between these disorders, but this requires further study. Although there do not appear to be significant cultural variations in rates or patterns of comorbidity and suicidality, further research using similar recruitment strategies and controlling for demographic and clinical variables may help to determine whether any sociocultural factors protect against suicidal ideation or psychiatric comorbidity in patients with OCD.
Palavras-chave
Referências
- Angelakis I, 2015, CLIN PSYCHOL REV, V39, P1, DOI 10.1016/j.cpr.2015.03.002
- Brakoulias V, 2013, J NERV MENT DIS, V201, P452, DOI 10.1097/NMD.0b013e318294804e
- Brown TA, 1994, COMMUNICATION
- De Berardis D, 2015, COMPR PSYCHIAT, V58, P82, DOI 10.1016/j.comppsych.2014.12.016
- de Mathis MA, 2013, EUR NEUROPSYCHOPHARM, V23, P594, DOI 10.1016/j.euroneuro.2012.08.006
- de la Cruz LF, 2016, MOL PSYCHIAT
- Fawzy N., 2011, MIDDLE E CURR PSYCHI, V18, P18, DOI 10.1097/01.XME.0000392844.09854.26
- First M., 2007, SCID I P
- GOODMAN WK, 1989, ARCH GEN PSYCHIAT, V46, P1006
- Kalra H, 2008, COMPR PSYCHIAT, V49, P51, DOI 10.1016/j.comppsych.2007.08.005
- Kamath P, 2007, J CLIN PSYCHIAT, V68, P1741
- Kanwar A, 2013, DEPRESS ANXIETY, V30, P917, DOI 10.1002/da.22074
- Kessler RC, 2007, LIFETIME PREVALENCE
- Lieb R, 2016, DEPRESS ANXIETY, V33, P667, DOI 10.1002/da.22487
- Lochner C, 2014, COMPR PSYCHIAT, V55, P1513, DOI 10.1016/j.comppsych.2014.05.020
- Lochner C, 2011, PROG NEURO-PSYCHOPH, V35, P1087, DOI 10.1016/j.pnpbp.2011.03.006
- Miguel EC, 2008, REV BRAS PSIQUIATR, V30, P185, DOI 10.1590/S1516-44462008000300003
- Ruscio AM, 2010, MOL PSYCHIATR, V15, P53, DOI 10.1038/mp.2008.94
- Sheehan DV, 1998, J CLIN PSYCHIAT, V59, P22, DOI 10.4088/JCP.09m05305whi
- Sheehan DV, 1998, J CLIN PSYCHIAT S20, V59, P4
- Sheehan DV, COMMUNICATION
- Starcevic V, 2014, CURR OPIN PSYCHIATR, V27, P62, DOI 10.1097/YCO.0000000000000030
- Torres AR, 2016, J AFFECT DISORDERS, V190, P508, DOI 10.1016/j.jad.2015.10.051
- Torres AR, 2011, J CLIN PSYCHIAT, V72, P17, DOI 10.4088/JCP.09m05651blu
- Torres AR, 2007, CNS SPECTRUMS, V12, P771
- Tukel R, 2002, COMPR PSYCHIAT, V43, P204, DOI 10.1053/comp.2002.32355
- Velloso P, 2016, EUR PSYCHIAT, V38, P1, DOI 10.1016/j.eurpsy.2016.05.003
- Yaryura-Tobias JA, 2000, J ANXIETY DISORD, V14, P19, DOI 10.1016/S0887-6185(99)00027-4