Impact of diabetes mellitus on arterial stiffness in a representative sample of an urban Brazilian population

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorALVIM, Rafael de Oliveira
dc.contributor.authorSANTOS, Paulo Caleb Junior Lima
dc.contributor.authorMUSSO, Mariane Manso
dc.contributor.authorCUNHA, Roberto de Sa
dc.contributor.authorKRIEGER, Jose Eduardo
dc.contributor.authorMILL, Jose Geraldo
dc.contributor.authorPEREIRA, Alexandre Costa
dc.date.accessioned2014-01-28T22:19:24Z
dc.date.available2014-01-28T22:19:24Z
dc.date.issued2013
dc.description.abstractBackground: Independent of other cardiovascular (CV) risk factors, increased arterial stiffness has been established as a predictor of morbidity and mortality. The main aim of this study was to investigate the impact of diabetes on arterial stiffness in a representative sample of an urban Brazilian population plus Amerindians. Methods: A total of 1,415 individuals from the general population were randomly selected plus 588 Amerindians from a native community in Brazil. In addition, a sub-sample of 380 individuals from the general population had 5-year follow-up data. Pulse wave velocity (PWV) was measured with a non-invasive automatic device (Complior, Colson; Garges les Gonesses, France) and increased arterial stiffness was defined as PWV >= 12 m/s. Results: In the overall group, diabetic individuals had higher frequencies of increased arterial stiffness and hypertension. They also had higher values of PWV, body mass index, total cholesterol, triglycerides, systolic and diastolic blood pressures compared to non-diabetic individuals (p < 0.01). In an analysis stratified by hypertension, PWV values and increased arterial stiffness frequency were higher in diabetic individuals in both groups (hypertensive and non-hypertensive) (p < 0.05). Furthermore, higher risk for increased arterial stiffness was observed in the diabetic individuals from the overall group (OR = 2.27; CI = 1.47-3.52, p < 0.001) and from the hypertensive group (OR = 2.70; CI = 1.58-4.75, p < 0.001), adjusted for covariates. Regarding the ethnic stratification, diabetic individuals from Amerindian, White, and Mulatto (mixed-race) groups had higher PWV values and a greater frequency of increased arterial stiffness compared to non-diabetic individuals. Both diabetic and non-diabetic individuals had higher PWV values after 5 years. There was no significant difference in the 5-year PWV progression in diabetic compared to non-diabetic individuals. Conclusions: These results confirm, in a sample of Brazilian population, that the presence of diabetes is associated with increased arterial stiffness and it may contribute in part to increased cardiovascular risk in diabetic patients.
dc.description.indexPubMed
dc.description.sponsorshipFAPESP, Brazil [Proc. 2010-17465-8]
dc.identifier.citationDIABETOLOGY & METABOLIC SYNDROME, v.5, article ID 45, 8p, 2013
dc.identifier.doi10.1186/1758-5996-5-45
dc.identifier.issn1758-5996
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/3965
dc.language.isoeng
dc.publisherBIOMED CENTRAL LTD
dc.relation.ispartofDiabetology & Metabolic Syndrome
dc.rightsopenAccess
dc.rights.holderCopyright BIOMED CENTRAL LTD
dc.subjectArterial stiffness
dc.subjectDiabetes mellitus
dc.subjectHypertension
dc.subjectBrazilian population
dc.subject.otherpulse-wave velocity
dc.subject.othernutrition examination survey
dc.subject.otherimpaired fasting glucose
dc.subject.othercoronary-heart-disease
dc.subject.otheraortic stiffness
dc.subject.othercardiovascular mortality
dc.subject.otherblood-pressure
dc.subject.otheressential-hypertension
dc.subject.othermyocardial-infarction
dc.subject.otherindependent predictor
dc.subject.wosEndocrinology & Metabolism
dc.titleImpact of diabetes mellitus on arterial stiffness in a representative sample of an urban Brazilian population
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalMUSSO, Mariane Manso:Univ Fed Juiz de Fora, Dept Med, Juiz De Fora, MG, Brazil
hcfmusp.citation.scopus41
hcfmusp.contributor.author-fmusphcRAFAEL DE OLIVEIRA ALVIM
hcfmusp.contributor.author-fmusphcPAULO CALEB JUNIOR DE LIMA SANTOS
hcfmusp.contributor.author-fmusphcJOSE EDUARDO KRIEGER
hcfmusp.contributor.author-fmusphcALEXANDRE DA COSTA PEREIRA
hcfmusp.description.articlenumber45
hcfmusp.description.volume5
hcfmusp.origemWOS
hcfmusp.origem.pubmed23965633
hcfmusp.origem.scopus2-s2.0-84883243531
hcfmusp.origem.wosWOS:000323525300001
hcfmusp.publisher.cityLONDON
hcfmusp.publisher.countryENGLAND
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