Prospective study of inflammatory response in patients submitted to abdominoplasty after bariatric surgery [Estudo prospectivo da reposta inflamatória em pacientes submetidas à abdominoplastia pós-cirurgia bariátrica]

Imagem de Miniatura
Arquivos
art_GIULIANI_Prospective_study_of_inflammatory_response_in_patients_submitted_2021_por.PDF (469.97 KB)
art_GIULIANI_Prospective_study_of_inflammatory_response_in_patients_submitted_2021_eng.PDF (462.41 KB)
Citações na Scopus
1
Tipo de produção
article
Data de publicação
2021
DOI
Scopus
Título da Revista
ISSN da Revista
Título do Volume
Editora
SOCIEDADE BRASILEIRA DE CIRURGIA PLASTICA (SBCP)
Autores
Citação
REVISTA BRASILEIRA DE CIRURGIA PLASTICA, v.36, n.2, p.129-133, 2021
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Introduction: Obesity is a chronic inflammatory disease associated with changes in inflammatory markers such as interleukins and CRP. This study evaluates the inflammatory response, through variations in interleukins and CRP, in patients undergoing abdominoplasty. Methods: Fourteen patients underwent abdominoplasty after weight loss achieved through bariatric surgery to maintain weight loss for at least18 months. Il4, IL6, IL10 and PCR levels were verified at times: preoperative, during surgery, 24 hours after surgery, 7th postoperative day and 14th postoperative day. Results: IL4 increased in the 24 hours postoperatively and continued on the rise until the 14th day. IL10 went up during surgery and began to fall in the 24 hours postoperatively to levels lower than the initial ones. IL6 began to rise during surgery, being more expressive in the 24 hours postoperatively, followed by a fall until the 14th day. CRP increased 24 hours postoperatively and remained discharged until the 14th day. Conclusion: Abdominoplasty reduced the chronic inflammatory systemic condition. © 2021, Sociedade Brasileira de Cirurgia Plastica (SBCP). All rights reserved.
Introdução: A obesidade é uma doença inflamatória crônica associada a alterações de marcadores inflamatórios como as interleucinas e PCR. O objetivo deste estudo é avaliar a resposta inflamatória, através das variações das interleucinas e PCR, em pacientes submetidas à abdominoplastia. Métodos: Quatorze pacientes foram submetidas à abdominoplastia após perda ponderal alcançada por meio da cirurgia bariátrica com manutenção da perda ponderal por, ao menos, 18 meses. Os níveis de IL4, IL6, IL10 e PCR foram verificados nos tempos: pré-operatório, durante a cirurgia, 24 horas após a cirurgia, 7o dia pós-operatório e 14o dia pós-operatório. Resultados: IL4 aumentou nas 24 horas de pós-operatório e seguiu em ascensão até o 14 o dia. IL10 subiu durante a cirurgia e começou a cair nas 24 horas de pós-operatório a níveis inferiores aos iniciais. IL6 começou a subir durante a cirurgia, mais expressivamente nas 24 horas de pós-operatório, seguida de queda até o 14o dia. A PCR aumentou nas 24 horas de pós-operatório e continuou alta até o 14o dia. Conclusão: A abdominoplastia promoveu uma amenização do quadro inflamatório sistêmico crônico.
Palavras-chave
Abdominoplasty, Bariatric surgery, Inflammation, Inflammation Mediators, Obesity, Plastic surgery, Obesidade, Cirurgia plástica, Abdominoplastia, Inflamação, Mediadores da Inflamação, Cirurgia bariátrica
URI
https://observatorio.fm.usp.br/handle/OPI/49007
Referências
  1. Gallo, JRB, Maschi-Signorini, LB, Cabral, CRB, Zuccari, DAPC, Nogueira, ML, Bozzola, AR, Skin protein profile after major weight loss and its role in body contouring surgery (2019) Plast Reconstr Surg Glob Open, 7 (8), p. e2339. , https://doi.org/10.1097/GOX.0000000000002339, Ago
  2. Mathis, D., Immunological goings-on in visceral adipose tissue (2013) Cell Metab, 17 (6), pp. 851-859. , https://doi.org/10.1016/j.cmet.2013.05.008, Jun
  3. Zeyda, M, Stulnig, TM., Obesity, inflammation, and insulin resistance--a mini-review (2009) Gerontology, 55 (4), pp. 379-386
  4. Hotamisligil, GS., Inflammation and metabolic desorders (2006) Nature, 444 (7121), pp. 860-867
  5. Bulló, M, Casas-Agustench, P, Amigó-Correig, P, Aranceta, J, Salas Salvadó, J., Inflammation, obesity and comorbidities: the role of diet (2007) Public Health Nutr, 10 (10A), pp. 1164-1172. , Out
  6. Shah, A, Mehta, N, Reilly, MP., Adipose inflammation, insulin resistance, and cardiovascular disease (2008) JPEN J Parenter Enteral Nutr, 32 (6), pp. 638-644. , Nov/Dez
  7. Modolin, MLA, Wilson Junior, C, Rocha, RI, Camargo, CP, Giuliani, NR, Gemperli, R., Analysis of inflammatory and metabolic bomarkers in pacientes submetted to abdominoplasty after bariatric surgery (2019) Acta Cir Bras, 34 (5), p. e201900506. , http://dx.doi.org/10.1590/s0102-86502019005000000
  8. Correa-Iturraspe, M., Tratamiento quirurgico de la obesidad (1952) Rev Assoc Med Argent, 66, pp. 340-345
  9. Freitas Junior, WR, Oliveira, LVF, Perez, EA, Ilias, EJ, Lottenberg, CP, Silva, AS, Systemic inflammation in severe obese patients undergoing surgery for obesity and weight-related diseases (2018) Obes Surg, 28, pp. 1931-1942. , https://doi.org/10.1007/s11695-017-3104-9
  10. Chiappetta, S, Schaack, HM, Wölnerhannsen, B, Stier, C, Squillante, S, Weiner, RA., The impact of obesity and metabolic surgery on chronic inflammation (2018) Obes Surg, 28, pp. 3028-3040. , https://doi.org/10.1007/s11695-018-3320-y
  11. Sippel, C, Bastian, RMA, Giovanella, J, Faccin, C, Contini, V, Dal Bosco, SM., Processos inflamatórios da obesidade (2014) RAS, 12 (42), pp. 48-56. , Out/Dez
  12. Gómez, FI, Ortega, MG, Alonso, AA, Soler, IO, Tafalla, SA, Paredes, MP, Obesity, endothelial function and inflammation: the effects of weight loss after bariatric surgery (2016) Nutr Hosp, 33 (6), pp. 1340-1346. , Nov
  13. Kohen, VL, Candela, CG, Fernández, CF, Rosa, LZ, Milla, SP, Urbieta, M, Parámetros hormonales e inflamatorios en un grupo de mujeres com sobrepeso/obesidad (2011) Nutr Hosp, 26 (4), pp. 884-889
  14. Arismendi, E, Rivas, E, Agustí, A, Rios, J, Barreiro, J, Vidal, J, The systemic inflammome of severe obesity before and after bariatric surgery (2014) Obes Sist Inflamm, 9 (9), p. e107859
  15. Lasselin, J, Magne, E, Beau, C, Ledaguenel, P, Dexpert, S, Aubert, A, Adipose inflammation in obesity: relationship with circulating levels of inflammatory markers and association with surgery-induced weight loss (2014) J Clin Endocrinol Metab, 99 (1), pp. E53-E61. , https://doi.org/10.1210/jc.2013-2673, Jan
  16. Barnes, MA, Carson, MJ, Nair, MG., Non-traditional cytokines: how catecolamines and adipokines influence macrofages in immunity, metabolismo and central nervous system (2015) Cytokine, 72 (2), pp. 210-219
  17. Hanusch-Enserer, U, Cauza, E, Spak, M, Dunky, A, Rosen, HR, Wolf, H, Acute-phase response and immunological markers in morbid obese patients and patients following adjustable gastric banding (2003) Int J Obes, 27 (3), pp. 355-361. , https://doi:10.1038/sj.ijo.802240, Mar
  18. Pamanicolau, DA, Wilder, RL, Manolagas, SC, Chrousos, GP., The pathophysiologic roles of interleukin-6 in human disease (1998) Ann Intern Med, 128 (2), pp. 127-137. , Jan
  19. Wilson Junior, C, Modolin, MLA, Gemperli, R, Gobbi, CIC, Faintuch, J, Ferreira, MA., Quality of life after abdominoplasty in women after bariatric surgery (2008) Obes Surg, 18 (6), pp. 728-732. , Jun
  20. Modolin, MLA, Wilson Junior, C, Rocha, RI, Faintuch, J, Camargo, CP, Gemperli, R., Quality of life after postbariatric abdominoplasty in females: interest of age, current weight and weight loss (2015) J Obes Weight Loss Ther, 5, p. 272

Coleções
Artigos e Materiais de Revistas Científicas - FM/MCG
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/04
Artigos e Materiais de Revistas Científicas - ODS/03