High maternal sodium intake alters sex-specific renal renin-angiotensin system components in newborn Wistar offspring

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art_MAIA_High_maternal_sodium_intake_alters_sexspecific_renal_reninangiotensin_2016.PDF (409.92 KB)
Citações na Scopus
1
Tipo de produção
article
Data de publicação
2016
DOI
Scopus
Web of Science
Título da Revista
ISSN da Revista
Título do Volume
Editora
CAMBRIDGE UNIV PRESS
Autores
Citação
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, v.7, n.3, p.282-289, 2016
Projetos de Pesquisa
Unidades Organizacionais
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Resumo
This study aimed to evaluate the systemic and renal renin-angiotensin-aldosterone system (RAAS) at birth in male and female offspring and in mothers fed a high sodium diet (HSD) before and during gestation. Female Wistar rats were fed a HSD (8.0% NaCl) or a normal sodium diet (1.3% NaCl) from 8 weeks of age until delivery of their first litter. Maternal body weight, tail blood pressure, and food and water intake were evaluated. The litter sizes were assessed, and the body and kidney weights of the offspring were measured. Both mothers and offspring were euthanized immediately following the birth of the pups to evaluate plasma renin activity (PRA), renal renin content (RRC), renal angiotensin-converting enzyme (ACE) activity, renal angiotensin (Ang) II content, serum aldosterone (ALDO) levels, and renal cortical and medullary renin messenger RNA expression. In mothers in the HSD group, water intake and kidney mass were higher, whereas renal ACE activity, Ang II, PRA, ALDO and RRC were decreased. In the offspring of HSD-fed dams, the body and kidney mass were lower in both genders, renal ACE activity was lower in females and renal Ang II was lower in males. PRA, RRC, renin gene expression and ALDO levels did not differ between the groups of offspring. The data presented herein showed that a maternal HSD during pregnancy induces low birth weight and a sex-specific response in the RAAS in offspring.
Palavras-chave
high sodium diet, newborn, offspring, renin-angiotensin-aldosterone system
URI
https://observatorio.fm.usp.br/handle/OPI/16095
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/08
Artigos e Materiais de Revistas Científicas - LIM/16