Rethinking the multiple roles of B cells in organ transplantation

Página do item simplificado
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCOELHO, Veronica
dc.contributor.authorSAITOVITCH, David
dc.contributor.authorKALIL, Jorge
dc.contributor.authorSILVA, Hernandez Moura
dc.date.accessioned2014-01-28T22:17:22Z
dc.date.available2014-01-28T22:17:22Z
dc.date.issued2013
dc.description.abstractPurpose of review To discuss the B-cell diverse functions in organ transplantation, highlighting the emerging debate on the role of regulatory B cells (Bregs). We underscore the need to re-examine and integrate data on B-cell functional activities, aiming to discriminate their regulatory (REG) and inflammatory (INFLAMMA) functions and to translate this knowledge for the development of novel immunomodulatory therapeutic strategies and to rethink the current ones. Recent findings Data from both experimental models and clinical trials point that B cells of various phenotypes have immunoregulatory activity and play an important role in controlling graft inflammation. Data on the state of operational tolerance, in kidney transplantation, suggest the relevance of preserving a healthy B-cell compartment - in numbers and in the Breg capacity to activate the CD40/STAT3 signalling pathway - for achieving and maintaining homeostasis. Moreover, autoantibodies also comprise transplant immunobiology and it seems that not all alloantibodies are deleterious. Summary The role of B cells, in organ transplantation, can no longer be taken as mere generators of plasma cells, which produce alloantibodies deleterious to the graft. B cells also seem to integrate a complex immunoregulatory network in organ transplantation, with Bregs of various phenotypes and possibly also antibodies. The functional discrimination of REG/INFLAMMA B-cell roles needs to be considered in the clinical setting.
dc.description.indexMEDLINE
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [07/59290-7]
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq
dc.description.sponsorshipiii/INCT) [573879-2008-7]
dc.identifier.citationCURRENT OPINION IN ORGAN TRANSPLANTATION, v.18, n.1, p.13-21, 2013
dc.identifier.doi10.1097/MOT.0b013e32835c8043
dc.identifier.issn1087-2418
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/3927
dc.language.isoeng
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.relation.ispartofCurrent Opinion in Organ Transplantation
dc.rightsrestrictedAccess
dc.rights.holderCopyright LIPPINCOTT WILLIAMS & WILKINS
dc.subjectalloantibodies
dc.subjectautoantibodies
dc.subjectB cells
dc.subjectregulatory B cells
dc.subjectreshaping the B-cell compartment
dc.subjecttransplantation tolerance
dc.subject.otherrenal-allograft recipients
dc.subject.otherhuman-leukocyte antigen
dc.subject.otherexperimental autoimmune encephalomyelitis
dc.subject.otherdose cyclosporine monotherapy
dc.subject.otherantibody-mediated rejection
dc.subject.otherprimary graft dysfunction
dc.subject.otherdonor-specific antibodies
dc.subject.otherregulatory t-cells
dc.subject.otheroperational tolerance
dc.subject.otherhla antibodies
dc.subject.wosTransplantation
dc.titleRethinking the multiple roles of B cells in organ transplantation
dc.typearticle
dc.type.categoryreview
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalSAITOVITCH, David:Natl Inst Sci & Technol INCT, III, Sao Paulo, Brazil; Pontificia Univ Catolica Rio Grande do Sul, Div Nephrol, Sao Lucas Hosp, Porto Alegre, RS, Brazil
hcfmusp.citation.scopus19
hcfmusp.contributor.author-fmusphcVERONICA PORTO CARREIRO DE VASCONCELLOS COELHO
hcfmusp.contributor.author-fmusphcJORGE ELIAS KALIL FILHO
hcfmusp.contributor.author-fmusphcHERNANDEZ MOURA SILVA
hcfmusp.description.beginpage13
hcfmusp.description.endpage21
hcfmusp.description.issue1
hcfmusp.description.volume18
hcfmusp.origemWOS
hcfmusp.origem.pubmed23254702
hcfmusp.origem.scopus2-s2.0-84872976616
hcfmusp.origem.wosWOS:000313963400003
hcfmusp.publisher.cityPHILADELPHIA
hcfmusp.publisher.countryUSA
hcfmusp.relation.referenceAdis R&D Profile, 2010, DRUGS R D, V10, P55
hcfmusp.relation.referenceAshton-Chess J, 2009, TRANSPLANTATION, V87, pS95, DOI 10.1097/TP.0b013e3181a2e295
hcfmusp.relation.referenceAzimzadeh AM, 2005, AM J TRANSPLANT, V5, P2349, DOI 10.1111/j.1600-6143.2005.01022.x
hcfmusp.relation.referenceBattaglia M, 2006, J IMMUNOL, V177, P8338
hcfmusp.relation.referenceBecker YT, 2006, TRANSPLANT INT, V19, P621, DOI 10.1111/j.1432-2277.2006.00345.x
hcfmusp.relation.referenceBlair PA, 2010, IMMUNITY, V32, P129, DOI 10.1016/j.immuni.2009.11.009
hcfmusp.relation.referenceBloom D, 2009, AM J TRANSPLANT, V9, P1835, DOI 10.1111/j.1600-6143.2009.02710.x
hcfmusp.relation.referenceBrouard S, 2007, P NATL ACAD SCI USA, V104, P15448, DOI 10.1073/pnas.0705834104
hcfmusp.relation.referenceBuggins AGS, 2002, BLOOD, V100, P1715
hcfmusp.relation.referenceCalne R, 1998, LANCET, V351, P1701, DOI 10.1016/S0140-6736(05)77739-4
hcfmusp.relation.referenceCalne R, 1999, TRANSPLANTATION, V68, P1613, DOI 10.1097/00007890-199911270-00032
hcfmusp.relation.referenceCherukuri A, 2012, AM J TRANSPLANT, V12, P919, DOI 10.1111/j.1600-6143.2011.03891.x
hcfmusp.relation.referenceChong AS, 2011, AM J TRANSPLANT, V11, P2555, DOI 10.1111/j.1600-6143.2011.03773.x
hcfmusp.relation.referenceClatworthy MR, 2009, NEW ENGL J MED, V360, P2683, DOI 10.1056/NEJMc0808481
hcfmusp.relation.referenceClatworthy MR, 2011, AM J TRANSPLANT, V11, P1359, DOI 10.1111/j.1600-6143.2011.03554.x
hcfmusp.relation.referenceCobbold S, 1998, CURR OPIN IMMUNOL, V10, P518, DOI 10.1016/S0952-7915(98)80217-3
hcfmusp.relation.referenceCohen IR, 2007, NAT REV IMMUNOL, V7, P569, DOI 10.1038/nri2102
hcfmusp.relation.referenceCohen IR, 2007, J AUTOIMMUN, V29, P246, DOI 10.1016/j.jaut.2007.07.016
hcfmusp.relation.referenceCrawford A, 2006, J IMMUNOL, V176, P3498
hcfmusp.relation.referenceDanger R, 2012, J AM SOC NEPHROL, V23, P597, DOI 10.1681/ASN.2011060543
hcfmusp.relation.referenceDiLillo DJ, 2011, J IMMUNOL, V186, P2643, DOI 10.4049/jimmunol.1002983
hcfmusp.relation.referenceDing Q, 2011, J CLIN INVEST, V121, P3645, DOI 10.1172/JCI46274
hcfmusp.relation.referenceDragun D, 2005, NEW ENGL J MED, V352, P558, DOI 10.1056/NEJMoa035717
hcfmusp.relation.referenceDunn TB, 2011, AM J TRANSPLANT, V11, P2132, DOI 10.1111/j.1600-6143.2011.03640.x
hcfmusp.relation.referenceEverly MJ, 2008, TRANSPLANTATION, V86, P1754, DOI 10.1097/TP.0b013e318190af83
hcfmusp.relation.referenceFehr T, 2009, TRANSPLANTATION, V87, P1837, DOI 10.1097/TP.0b013e3181a6bac5
hcfmusp.relation.referenceFillatreau S, 2002, NAT IMMUNOL, V3, P944, DOI 10.1038/ni833
hcfmusp.relation.referenceGasser M, 2002, TRANSPLANT P, V34, P2244, DOI 10.1016/S0041-1345(02)03221-9
hcfmusp.relation.referenceGoers TA, 2008, J IMMUNOL, V180, P4487
hcfmusp.relation.referenceGraff RJ, 2009, HUM IMMUNOL, V70, P502, DOI 10.1016/j.humimm.2009.04.002
hcfmusp.relation.referenceGuo HL, 2010, NATURE, V466, P835, DOI 10.1038/nature09267
hcfmusp.relation.referenceHagedorn PH, 2010, IMMUNOLOGY, V130, P427, DOI 10.1111/j.1365-2567.2010.03246.x
hcfmusp.relation.referenceHale G, 1983, Mol Biol Med, V1, P321
hcfmusp.relation.referenceHALE G, 1990, TISSUE ANTIGENS, V35, P118, DOI 10.1111/j.1399-0039.1990.tb01767.x
hcfmusp.relation.referenceHanaway MJ, 2011, NEW ENGL J MED, V364, P1909, DOI 10.1056/NEJMoa1009546
hcfmusp.relation.referenceHarris DP, 2005, J IMMUNOL, V174, P6781
hcfmusp.relation.referenceHarris DP, 2000, NAT IMMUNOL, V1, P475, DOI 10.1038/82717
hcfmusp.relation.referenceHashimoto Y, 2002, BLOOD, V100, P3504, DOI 10.1182/blood-2002-03-0733
hcfmusp.relation.referenceHeidt S, 2012, AM J TRANSPLANT, V12, P1784, DOI 10.1111/j.1600-6143.2012.04012.x
hcfmusp.relation.referenceIwata T, 2008, J IMMUNOL, V181, P5738
hcfmusp.relation.referenceIwata Y, 2011, BLOOD, V117, P530, DOI 10.1182/blood-2010-07-294249
hcfmusp.relation.referenceJindra PT, 2006, TRANSPLANTATION, V82, pS33, DOI 10.1097/01.tp.0000231447.34240.3c
hcfmusp.relation.referenceJonker M, 2005, TRANSPLANTATION, V80, P385, DOI 10.1097/01.tp.0000166920.18998.15
hcfmusp.relation.referenceKamburova EG, 2012, AM J TRANSPLANT, V12, P341, DOI 10.1111/j.1600-6143.2011.03833.x
hcfmusp.relation.referenceKaneku H, 2012, LIVER TRANSPLANT, V18, P984, DOI 10.1002/lt.23451
hcfmusp.relation.referenceKokko KE, 2012, AM J TRANSPLANT, V12, P1077, DOI 10.1111/j.1600-6143.2012.04016.x
hcfmusp.relation.referenceKweon MN, 1998, J IMMUNOL, V160, P1687
hcfmusp.relation.referenceKwun J, 2012, SEMIN IMMUNOL, V24, P96, DOI 10.1016/j.smim.2011.08.022
hcfmusp.relation.referenceLaMattina JC, 2012, TRANSPL INT, V25, P518, DOI 10.1111/j.1432-2277.2012.01448.x
hcfmusp.relation.referenceLechler R, 2001, IMMUNITY, V14, P357, DOI 10.1016/S1074-7613(01)00116-9
hcfmusp.relation.referenceLe Texier L, 2011, AM J TRANSPLANT, V11, P429, DOI 10.1111/j.1600-6143.2010.03336.x
hcfmusp.relation.referenceLinton PJ, 2000, J IMMUNOL, V165, P5558
hcfmusp.relation.referenceLund FE, 2010, NAT REV IMMUNOL, V10, P236, DOI 10.1038/nri2729
hcfmusp.relation.referenceMackay F, 2002, NAT REV IMMUNOL, V2, P465, DOI 10.1038/nri844
hcfmusp.relation.referenceMackay F, 2009, NAT REV IMMUNOL, V9, P491, DOI 10.1038/nri2572
hcfmusp.relation.referenceMackay F, 2003, ANNU REV IMMUNOL, V21, P231, DOI 10.1146/annurev.immunol.21.120601.141152
hcfmusp.relation.referenceMann MK, 2007, J IMMUNOL, V178, P3447
hcfmusp.relation.referenceMauri C, 2003, J EXP MED, V197, P489, DOI 10.1084/jem.20021293
hcfmusp.relation.referenceMauri C, 2012, ANNU REV IMMUNOL, V30, P221, DOI 10.1146/annurev-immunol-020711-074934
hcfmusp.relation.referenceMauri C, 2010, NAT REV RHEUMATOL, V6, P636, DOI 10.1038/nrrheum.2010.140
hcfmusp.relation.referenceMeister S, 2007, CANCER RES, V67, P1783, DOI 10.1158/0008-5472.CAN-06-2258
hcfmusp.relation.referenceMerbl Y, 2007, J CLIN INVEST, V117, P712, DOI 10.1072/JC129943
hcfmusp.relation.referenceMizoguchi A, 2006, J IMMUNOL, V176, P705
hcfmusp.relation.referenceMizoguchi A, 2002, IMMUNITY, V16, P219, DOI 10.1016/S1074-7613(02)00274-1
hcfmusp.relation.referenceMoraes-Vieira PMM, 2010, HUM IMMUNOL, V71, P442, DOI 10.1016/j.humimm.2010.01.022
hcfmusp.relation.referenceMoraes-Vieira PMM, 2012, CLIN IMMUNOL, V142, P117, DOI 10.1016/j.clim.2011.08.015
hcfmusp.relation.referenceNath DS, 2011, TRANSPLANTATION, V91, P1036, DOI 10.1097/TP.0b013e318211d2f4
hcfmusp.relation.referenceNewell KA, 2010, J CLIN INVEST, V120, P1836, DOI 10.1172/JCI39933
hcfmusp.relation.referenceNewell KA, 2011, CURR OPIN IMMUNOL, V23, P655, DOI 10.1016/j.coi.2011.07.008
hcfmusp.relation.referenceNoorchashm H, 2006, J IMMUNOL, V177, P7715
hcfmusp.relation.referenceObeng EA, 2006, BLOOD, V107, P4907, DOI 10.1182/blood-2005-08-3531
hcfmusp.relation.referenceOlofsson PS, 2012, IMMUNOL REV, V248, P188, DOI 10.1111/j.1600-065X.2012.01138.x
hcfmusp.relation.referenceOtto C, 2001, TRANSPLANT P, V33, P431, DOI 10.1016/S0041-1345(00)02079-0
hcfmusp.relation.referencePallier A, 2010, KIDNEY INT, V78, P503, DOI 10.1038/ki.2010.162
hcfmusp.relation.referenceParsons RF, 2012, TRANSPLANTATION, V93, P676, DOI 10.1097/TP.0b013e318246621d
hcfmusp.relation.referencePIERCE SK, 1988, IMMUNOL REV, V106, P149, DOI 10.1111/j.1600-065X.1988.tb00778.x
hcfmusp.relation.referencePorcheray F, 2010, TRANSPLANTATION, V89, P1239, DOI 10.1097/TP.0b013e3181d72091
hcfmusp.relation.referencePortugal K, 2001, INT IMMUNOL, V13, P747, DOI 10.1093/intimm/13.6.747
hcfmusp.relation.referenceQin ZQ, 2011, TRANSPLANTATION, V92, P829, DOI 10.1097/TP.0b013e31822d0977
hcfmusp.relation.referenceQuintana FJ, 2006, LUPUS, V15, P428, DOI 10.1191/0961203306lu2328oa
hcfmusp.relation.referenceRedfield RR, 2011, CURR OPIN IMMUNOL, V23, P685, DOI 10.1016/j.coi.2011.07.011
hcfmusp.relation.referenceRiewaldt Julia, 2012, Front Immunol, V3, P141, DOI 10.3389/fimmu.2012.00141
hcfmusp.relation.referenceRogers NJ, 2001, AM J TRANSPLANT, V1, P97, DOI 10.1034/j.1600-6143.2001.10201.x
hcfmusp.relation.referenceRowe V, 2006, BLOOD, V108, P2485, DOI 10.1182/blood-2006-04-016063
hcfmusp.relation.referenceSagoo P, 2010, J CLIN INVEST, V120, P1848, DOI 10.1172/JCI39922
hcfmusp.relation.referenceSilva HM, 2012, MOL MED, V18, P733, DOI 10.2119/molmed.2011.00281
hcfmusp.relation.referenceSpadafora-Ferreira M, 2007, SCAND J IMMUNOL, V66, P352, DOI 10.1111/j.1365-3083.2007.01976.x
hcfmusp.relation.referenceStastny P, 2009, HUM IMMUNOL, V70, P600, DOI 10.1016/j.humimm.2009.04.017
hcfmusp.relation.referenceSun QQ, 2005, TRANSPLANTATION, V79, P1759, DOI 10.1097/01.TP.0000163290.19788.E7
hcfmusp.relation.referenceSun QQ, 2011, KIDNEY INT, V79, P655, DOI 10.1038/ki.2010.437
hcfmusp.relation.referenceSun QQ, 2008, CLIN J AM SOC NEPHRO, V3, P1479, DOI 10.2215/CJN.04451007
hcfmusp.relation.referenceSWAIN SL, 1987, IMMUNOL REV, V99, P263, DOI 10.1111/j.1600-065X.1987.tb01180.x
hcfmusp.relation.referenceThaunat O, 2011, TRANSPLANTATION, V92, P121, DOI 10.1097/TP.0b013e31821f74fe
hcfmusp.relation.referenceThaunat O, 2012, KIDNEY INT, V81, P207, DOI 10.1038/ki.2011.317
hcfmusp.relation.referenceThaunat O, 2010, J IMMUNOL, V185, P717, DOI 10.4049/jimmunol.0903589
hcfmusp.relation.referenceThibault-Espitia A, 2012, AM J TRANSPLANT, V12, P2754, DOI 10.1111/j.1600-6143.2012.04194.x
hcfmusp.relation.referenceThiyagarajan UM, 2012, TRANSPL P, V44, P1231, DOI 10.1016/j.transproceed.2011.10.054
hcfmusp.relation.referenceTrivedi HL, 2009, TRANSPLANTATION, V87, P1555, DOI 10.1097/TP.0b013e3181a4b91b
hcfmusp.relation.referenceTsang JYS, 2009, TRANSPL IMMUNOL, V21, P203, DOI 10.1016/j.trim.2009.05.003
hcfmusp.relation.referenceTsang JYS, 2008, J CLIN INVEST, V118, P3619, DOI 10.1172/JCI33185
hcfmusp.relation.referenceTyden G, 2009, TRANSPLANTATION, V87, P1325, DOI 10.1097/TP.0b013e3181a235fd
hcfmusp.relation.referenceUCKUN FM, 1990, BLOOD, V76, P1908
hcfmusp.relation.referenceVenetz JP, 2007, EXPERT OPIN INV DRUG, V16, P625, DOI 10.1517/13543784.16.5.625
hcfmusp.relation.referenceWaldmann H, 2006, IMMUNOL REV, V212, P301, DOI 10.1111/j.0105-2896.2006.00406.x
hcfmusp.relation.referenceWalsh RC, 2010, TRANSPLANTATION, V89, P277, DOI 10.1097/TP.0b013e3181c6ff8d
hcfmusp.relation.referenceWalsh RC, 2012, KIDNEY INT, V81, P1067, DOI 10.1038/ki.2011.502
hcfmusp.relation.referenceWalters S, 2009, J IMMUNOL, V182, P793
hcfmusp.relation.referenceWiebe C, 2012, AM J TRANSPLANT, V12, P1157, DOI 10.1111/j.1600-6143.2012.04013.x
hcfmusp.relation.referenceWilkes DS, 2012, SEMIN IMMUNOL, V24, P131, DOI 10.1016/j.smim.2011.08.020
hcfmusp.relation.referenceWolf SD, 1996, J EXP MED, V184, P2271, DOI 10.1084/jem.184.6.2271
hcfmusp.relation.referenceMorrow WR, 2012, TRANSPLANTATION, V93, P319, DOI 10.1097/TP.0b013e31823f7eea
hcfmusp.relation.referenceYanaba K, 2008, IMMUNITY, V28, P639, DOI 10.1016/j.immuni.2008.03.017
hcfmusp.relation.referenceZarkhin V, 2010, TRANSPLANT REV-ORLAN, V24, P67, DOI 10.1016/j.trre.2010.01.004
hcfmusp.relation.referenceZhou L, 2009, IMMUNITY, V30, P646, DOI 10.1016/j.immuni.2009.05.001
hcfmusp.remissive.sponsorshipCNPq
hcfmusp.remissive.sponsorshipFAPESP
hcfmusp.remissive.sponsorshipINCTs
hcfmusp.scopus.lastupdate2024-05-17
relation.isAuthorOfPublication1189856a-40b6-420f-862a-2048628b932e
relation.isAuthorOfPublication039713b4-cdee-430a-b5dd-77d7d751b09b
relation.isAuthorOfPublication2d3035e8-8d3e-4be6-9975-150828363f51
relation.isAuthorOfPublication.latestForDiscovery1189856a-40b6-420f-862a-2048628b932e
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
art_COELHO_Rethinking_the_multiple_roles_of_B_cells_in_2013.PDF
Tamanho:
283.88 KB
Formato:
Adobe Portable Document Format
Descrição:
publishedVersion (English)
Baixar
Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/19