The Effectiveness and Safety of the Duodenal-Jejunal Bypass Liner (DJBL) for the Management of Obesity and Glycaemic Control: a Systematic Review and Meta-Analysis of Randomized Controlled Trials

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorYVAMOTO, Erika Yuki
dc.contributor.authorMOURA, Diogo Turiani Hourneaux de
dc.contributor.authorPROENCA, Igor Mendonca
dc.contributor.authorMONTE JUNIOR, Epifanio Silvino do
dc.contributor.authorRIBEIRO, Igor Braga
dc.contributor.authorRIBAS, Pedro Henrique Boraschi Vieira
dc.contributor.authorHEMERLY, Matheus Candido
dc.contributor.authorOLIVEIRA, Victor Lira de
dc.contributor.authorSANCHEZ-LUNA, Sergio A.
dc.contributor.authorBERNARDO, Wanderley Marques
dc.contributor.authorMOURA, Eduardo Guimaraes Hourneaux de
dc.date.accessioned2023-12-15T19:08:37Z
dc.date.available2023-12-15T19:08:37Z
dc.date.issued2023
dc.description.abstractIntroduction The duodenal-jejunal bypass liner (DJBL) is a less-invasive treatment of obesity and type 2 diabetes mellitus (T2DM). Methods This is a systematic review and meta-analysis including randomized clinical trials (RCTs) comparing DJBL versus sham or pharmacotherapies aiming to evaluate the effectiveness and safety of DJBL. Results Ten RCTs (681 patients) were included. The DJBL group showed superior excess weight loss (+ 11.4% [+ 7.75 to + 15.03%], p < 0.00001) and higher decrease in HbA1c compared to the control group (- 2.73 +/- 0.5 vs. - 1.73 +/- 0.4, p = 0.0001). Severe adverse events (SAEs) occurred in 19.7%. Conclusion The DJBL did not reach the ASGE/ASMBS thresholds for the treatment of obesity. However, it is important to state that many SAEs were not really severe. Therefore, we believe this therapy plays an important role in the management obesity and T2DM.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.identifier.citationOBESITY SURGERY, v.33, n.2, p.585-599, 2023
dc.identifier.doi10.1007/s11695-022-06379-0
dc.identifier.eissn1708-0428
dc.identifier.issn0960-8923
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/57738
dc.language.isoeng
dc.publisherSPRINGEReng
dc.relation.ispartofObesity Surgery
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright SPRINGEReng
dc.subjectEndoscopyeng
dc.subjectDuodenal-jejunal bypass linereng
dc.subjectObesityeng
dc.subjectDiabeteseng
dc.subjectWeight Losseng
dc.subjectGlycaemic controleng
dc.subjectBariatric surgeryeng
dc.subjectMeta-analysiseng
dc.subjectSystematic revieweng
dc.subject.otherendobarrier gastrointestinal linereng
dc.subject.othertype-2 diabetes-mellituseng
dc.subject.otherweight-losseng
dc.subject.othermulticentereng
dc.subject.otherclassificationeng
dc.subject.otherexclusioneng
dc.subject.otherefficacyeng
dc.subject.othergradeeng
dc.subject.wosSurgeryeng
dc.titleThe Effectiveness and Safety of the Duodenal-Jejunal Bypass Liner (DJBL) for the Management of Obesity and Glycaemic Control: a Systematic Review and Meta-Analysis of Randomized Controlled Trialseng
dc.typearticleeng
dc.type.categoryrevieweng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalSANCHEZ-LUNA, Sergio A.:Univ Alabama Birmingham, Basil I Hirschowitz Endoscop Ctr Excellence, Heersink Sch Med,Dept Internal Med, Div Gastroenterol & Hepatol, Birmingham, AL USA
hcfmusp.citation.scopus7
hcfmusp.contributor.author-fmusphcERIKA YUKI YVAMOTO
hcfmusp.contributor.author-fmusphcDIOGO TURIANI HOURNEAUX DE MOURA
hcfmusp.contributor.author-fmusphcIGOR MENDONCA PROENCA
hcfmusp.contributor.author-fmusphcEPIFANIO SILVINO DO MONTE JUNIOR
hcfmusp.contributor.author-fmusphcIGOR BRAGA RIBEIRO
hcfmusp.contributor.author-fmusphcPEDRO HENRIQUE BORASCHI VIEIRA RIBAS
hcfmusp.contributor.author-fmusphcMATHEUS CANDIDO HEMERLY
hcfmusp.contributor.author-fmusphcVICTOR LIRA DE OLIVEIRA
hcfmusp.contributor.author-fmusphcWANDERLEY MARQUES BERNARDO
hcfmusp.contributor.author-fmusphcEDUARDO GUIMARAES HOURNEAUX DE MOURA
hcfmusp.description.beginpage585
hcfmusp.description.endpage599
hcfmusp.description.issue2
hcfmusp.description.volume33
hcfmusp.origemWOS
hcfmusp.origem.pubmed36508156
hcfmusp.origem.scopus2-s2.0-85143717538
hcfmusp.origem.wosWOS:000898328100004
hcfmusp.publisher.cityNEW YORKeng
hcfmusp.publisher.countryUNITED STATESeng
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