Recalling feature bindings differentiates Alzheimer's disease from frontotemporal dementia

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art_CECCHINI_Recalling_feature_bindings_differentiates_Alzheimers_disease_from_frontotemporal_2017.PDF (749 KB)
Citações na Scopus
25
Tipo de produção
article
Data de publicação
2017
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER HEIDELBERG
Autores
BAHIA, Valeria Santoro
SOUZA, Leonardo Cruz de
GUIMARAES, Henrique Cerqueira
CARAMELLI, Paulo
CARTHERY-GOULART, Maria Teresa
PATROCINIO, Flavia
FOSS, Maria Paula
TUMAS, Vitor
Citação
JOURNAL OF NEUROLOGY, v.264, n.10, p.2162-2169, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
It has been challenging to identify clinical cognitive markers that can differentiate patients with Alzheimer's disease (AD) from those with behavioral variant frontotemporal dementia (bvFTD). The short-term memory binding (STMB) test assesses the ability to integrate colors and shapes into unified representations and to hold them temporarily during online performance. The objective of this study is to investigate whether free recall deficits during short-term memory binding (STMB) test can differentiate patients with AD from those with bvFTD and controls. Participants were 32 cognitively intact adults, 35 individuals with AD and 18 with bvFTD. All patients were in the mild dementia stage. Receiver-operating characteristic (ROC) analyses were used to examine the diagnostic accuracy of the STMB. The results showed that AD patients performed significantly worse than controls and bvFTD patients in the STMB test, while the latter groups showed equivalent performance. The bound condition of the STMB test showed an AUC of 0.853, with 84.4% of sensitivity and 80% of specificity to discriminate AD from controls and an AUC of 0.794, with 72.2% of sensitivity and 80% of specificity to differentiate AD from bvFTD. Binding deficits seem specific to AD. The free recall version of the STMB test can be used for clinical purposes and may aid in the differential diagnosis of AD. Findings support the view that the STMB may be a suitable cognitive marker for AD.
Palavras-chave
Alzheimer's disease, Behavioral variant frontotemporal dementia, Differential diagnosis, Memory binding, Short-term memory
URI
https://observatorio.fm.usp.br/handle/OPI/24297
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MNE
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/15
Artigos e Materiais de Revistas Científicas - LIM/45