Cognitive Reserve Relates to Functional Network Efficiency in Alzheimer's Disease

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art_WEILER_Cognitive_Reserve_Relates_to_Functional_Network_Efficiency_in_2018.PDF (1.42 MB)
Citações na Scopus
26
Tipo de produção
article
Data de publicação
2018
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
FRONTIERS MEDIA SA
Autores
WEILER, Marina
CASSEB, Raphael Fernandes
CAMPOS, Brunno Machado de
TEIXEIRA, Camila Vieira de Ligo
CARLETTI-CASSANI, Ana Flavia Mac Knight
VICENTINI, Jessica Elias
MAGALHAES, Thamires Naela Cardoso
ALMEIRA, Debora Queiroz de
Citação
FRONTIERS IN AGING NEUROSCIENCE, v.10, article ID 255, 14p, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Alzheimer's disease (AD) is the most common form of dementia, with no means of cure or prevention. The presence of abnormal disease-related proteins in the population is, in turn, much more common than the incidence of dementia. In this context, the cognitive reserve (CR) hypothesis has been proposed to explain the discontinuity between pathophysiological and clinical expression of AD, suggesting that CR mitigates the effects of pathology on clinical expression and cognition. fMRI studies of the human connectome have recently reported that AD patients present diminished functional efficiency in resting-state networks, leading to a loss in information flow and cognitive processing. No study has investigated, however, whether CR modifies the effects of the pathology in functional network efficiency in AD patients. We analyzed the relationship between CR, pathophysiology and network efficiency, and whether CR modifies the relationship between them. Fourteen mild AD, 28 amnestic mild cognitive impairment (aMCI) due to AD, and 28 controls were enrolled. We used education to measure CR, cerebrospinal fluid (CSF) biomarkers to evaluate pathophysiology, and graph metrics to measure network efficiency. We found no relationship between CR and CSF biomarkers; CR was related to higher network efficiency in all groups; and abnormal levels of CSF protein biomarkers were related to more efficient networks in the AD group. Education modified the effects of tau-related pathology in the aMCI and mild AD groups. Although higher CR might not protect individuals from developing AD pathophysiology, AD patients with higher CR are better able to cope with the effects of pathology-presenting more efficient networks despite pathology burden. The present study highlights that interventions focusing on cognitive stimulation might be useful to slow age-related cognitive decline or dementia and lengthen healthy aging.
Palavras-chave
fMRI, graph theory, mild cognitive impairment, neuropathology, educational measurement, network efficiency
URI
https://observatorio.fm.usp.br/handle/OPI/28235
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - LIM/27