Correlation between cognitive impairment and retinal neural loss assessed by swept-source optical coherence tomography in patients with mild cognitive impairment

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art_ALMEIDA_Correlation_between_cognitive_impairment_and_retinal_neural_loss_2019.PDF (738.09 KB)
Citações na Scopus
29
Tipo de produção
article
Data de publicação
2019
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY
Autores
ALMEIDA, Ana L. M.
PIRES, Leopoldo A.
FIGUEIREDO, Evelyn A.
COSTA-CUNHA, Luciana V. F.
Citação
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING, v.11, n.1, p.659-669, 2019
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Introduction: We compared peripapillary retinal nerve fiber layer and macular thickness measurements in patients with mild cognitive impairment (MCI) and control subjects using swept-source optical coherence tomography (SS-OCT). We also assessed the relationship between SS-OCT measurements and the severity of cognitive impairment. Methods: Peripapillary retinal nerve fiber layer and macular thickness were measured in 23 patients and 24 control subjects using SS-OCT. Cognitive status was assessed using the Mini-Mental State Examination, the Montreal Cognitive Assessment, and the Pfeffer Questionnaire. Results: Most inner retinal layer thickness parameters were significantly smaller in patients with MCI, especially macular ganglion cell complex thickness measurements. Mini-Mental State Examination and Montreal Cognitive Assessment findings were significantly correlated with most macular thickness parameters. Discussion: The SS-OCT-measured inner retinal layers of patients with MCI displayed thinning, especially in the central macular area. SS-OCT technology can provide useful information on ocular involvement patterns and holds promise as an ocular biomarker in this patient population. (C) 2019 The Authors.
Palavras-chave
Mild cognitive impairment, Dementia, Alzheimer's disease, Optical coherence tomography, Swept-source, Macula, Retina, Optic nerve, Retinal nerve fiber layer, Ganglion cell layer
URI
https://observatorio.fm.usp.br/handle/OPI/44483
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MOF
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/33