A 6-year prospective clinical cohort study on the bidirectional association between frailty and depressive disorder

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorVOSHAAR, Richard C. Oude
dc.contributor.authorDIMITRIADIS, Menelaos
dc.contributor.authorVANDENBRINK, Rob H. S.
dc.contributor.authorAPRAHAMIAN, Ivan
dc.contributor.authorBORGES, Marcus K.
dc.contributor.authorMARIJNISSEN, Radboud M.
dc.contributor.authorHOOGENDIJK, Emiel O.
dc.contributor.authorRHEBERGEN, Didi
dc.contributor.authorJEURING, Hans W.
dc.date.accessioned2021-12-16T14:42:04Z
dc.date.available2021-12-16T14:42:04Z
dc.date.issued2021
dc.description.abstractIntroduction Depressive disorder has been conceptualised as a condition of accelerated biological ageing. We operationalised a frailty index (FI) as marker for biological ageing aimed to explore the bidirectional, longitudinal association between frailty and either depressive symptoms or depressive disorder. Methods A cohort study with 6-year follow-up including 377 older (>= 60 years) outpatients with a DSM-IV-defined depressive disorder and 132 never-depressed controls. Site visits at baseline, 2 and 6-year follow-up were conducted and included the CIDI 2.0 to assess depressive disorder and relevant covariates. Depressive symptom severity and mortality were assessed every 6 months by mail and telephone. A 41-item FI was operationalised and validated against the 6-year morality rate by Cox regression (HRFI = 1.04 [95% CI: 1.02-1.06]). Results Cox regression showed that a higher FI was associated with a lower chance of remission among depressed patients (HRFI = 0.98 [95% CI: 0.97-0.99]). Nonetheless, this latter effect disappeared after adjustment for baseline depressive symptom severity. Linear mixed models showed that the FI increased over time in the whole sample (B[SE] = 0.94 (0.12), p < .001) with a differential impact of depressive symptom severity and depressive disorder. Higher baseline depressive symptom severity was associated with an attenuated and depressive disorder with an accelerated increase of the FI over time. Conclusions The sum score of depression rating scales is likely confounded by frailty. Depressive disorder, according to DSM-IV criteria, is associated with accelerated biological ageing. This argues for the development of multidisciplinary geriatric care models incorporating frailty to improve the overall outcome of late-life depression.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipFonds NutsOhra
dc.description.sponsorshipStichting tot Steun Vereniging tot Christelijke Verzorging van Geestes-en Zenuwzieken
dc.description.sponsorshipVrije Universiteit Amsterdam
dc.description.sponsorshipLeids Universitair Medisch Centrum
dc.description.sponsorshipUniversitair Medisch Centrum Groningen
dc.identifier.citationINTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, v.36, n.11, p.1699-1707, 2021
dc.identifier.doi10.1002/gps.5588
dc.identifier.eissn1099-1166
dc.identifier.issn0885-6230
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/44033
dc.language.isoeng
dc.publisherWILEYeng
dc.relation.ispartofInternational Journal of Geriatric Psychiatry
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright WILEYeng
dc.subjectageingeng
dc.subjectbiological ageingeng
dc.subjectdepressive disordereng
dc.subjectfrailtyeng
dc.subjectfrailty indexeng
dc.subject.otherall-cause mortalityeng
dc.subject.otherlate-lifeeng
dc.subject.otherdeficit accumulationeng
dc.subject.otherolder-adultseng
dc.subject.otherphysical frailtyeng
dc.subject.otherindexeng
dc.subject.otherinflammationeng
dc.subject.othermetaanalysiseng
dc.subject.othernetherlandseng
dc.subject.otherpredictoreng
dc.subject.wosGeriatrics & Gerontologyeng
dc.subject.wosGerontologyeng
dc.subject.wosPsychiatryeng
dc.titleA 6-year prospective clinical cohort study on the bidirectional association between frailty and depressive disordereng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryHolanda
hcfmusp.affiliation.countryisonl
hcfmusp.author.externalVOSHAAR, Richard C. Oude:Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands
hcfmusp.author.externalDIMITRIADIS, Menelaos:Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands
hcfmusp.author.externalVANDENBRINK, Rob H. S.:Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands
hcfmusp.author.externalAPRAHAMIAN, Ivan:Fac Med Jundiai, Dept Internal Med, Geriatr Div, Jundiai, Brazil
hcfmusp.author.externalMARIJNISSEN, Radboud M.:Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands
hcfmusp.author.externalHOOGENDIJK, Emiel O.:Amsterdam UMC Locat VU Univ Med Ctr, Dept Epidemiol & Biostat, Amsterdam, Netherlands
hcfmusp.author.externalRHEBERGEN, Didi:Dept Psychiat, Amsterdam, Netherlands; Amsterdam UMC Locat VU Univ Med Ctr, GGZ Ingeest Specialized Mental Hlth Care, Amsterdam, Netherlands
hcfmusp.author.externalJEURING, Hans W.:Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands
hcfmusp.citation.scopus23
hcfmusp.contributor.author-fmusphcMARCUS KIITI BORGES
hcfmusp.description.beginpage1699
hcfmusp.description.endpage1707
hcfmusp.description.issue11
hcfmusp.description.volume36
hcfmusp.origemWOS
hcfmusp.origem.pubmed34130356
hcfmusp.origem.scopus2-s2.0-85108350161
hcfmusp.origem.wosWOS:000663401700001
hcfmusp.publisher.cityHOBOKENeng
hcfmusp.publisher.countryUSAeng
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