Maternal high-sodium intake alters the responsiveness of the renin-angiotensin system in adult offspring

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art_RAMOS_Maternal_high_sodium_intake_alters_the_responsiveness_of_2012.PDF (392.92 KB)
Citações na Scopus
7
Tipo de produção
article
Data de publicação
2012
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
PERGAMON-ELSEVIER SCIENCE LTD
Autores
COSTA, Nauilo L.
SILVA, Alexandre A. da
Citação
LIFE SCIENCES, v.90, n.19-20, p.785-792, 2012
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Aims: The goal of the current study was to evaluate the impact of maternal sodium intake during gestation on the systemic and renal renin-angiotensin-aldosterone-system (RAAS) of the adult offspring. Main methods: Female Wistar rats were fed high- (HSD-8.0% NaCl) or normal-sodium diets (NSD-1.3% NaCl) from 8 weeks of age until the delivery of their first litter. After birth, the offspring received NSD. Tail-cuff blood pressure (TcBP) was measured in the offspring between 6 and 12 weeks of age. At 12 weeks of age, the offspring were subjected to either one week of HSD or low sodium diet (LSD-0.1 6%NaCl) feeding to evaluate RAAS responsiveness or to acute saline overload to examine sodium excretory function. Plasma (PRA) and renal renin content (RRC), serum aldosterone (ALDO) levels, and renal cortical and medullary renin mRNA expression levels were evaluated at the end of the study. Key findings: TcBP was higher among dams fed HSD, but no TcBP differences were observed among the offspring. Male offspring, however, exhibited increased TcBP after one week of HSD feeding, and this effect was independent of maternal diet. Increased RAAS responsiveness to the HSD and LSD was also observed in male offspring. The baseline levels of PRA. ALDO, and cortical and medullary renin gene expression were lower but the RRC levels were higher among HSD-fed male offspring (HSDoff). Conversely, female HSDoff showed reduced sodium excretion 4 h after saline overload compared with female NSDoff. Significance: High maternal sodium intake is associated with gender-specific changes in RAAS responsiveness among adult offspring.
Palavras-chave
Renin-angiotensin system, Offspring, Maternal high-sodium diet
URI
https://observatorio.fm.usp.br/handle/OPI/552
Referências
  1. Augustyniak RA, 2010, AM J PHYSIOL-REG I, V298, pR1375, DOI 10.1152/ajpregu.00848.2009
  2. BARKER DJP, 1986, LANCET, V1, P1077
  3. Bedard S, 2005, J PHYSIOL-LONDON, V562, P937, DOI 10.1113/jphysiol.2004.064683
  4. Brosnihan KB, 1997, AM J PHYSIOL-REG I, V273, pR1908
  5. Castrop H, 2010, PHYSIOL REV, V90, P607, DOI 10.1152/physrev.00011.2009
  6. Chamarthi B, 2010, J HYPERTENS, V28, P1020, DOI 10.1097/HJH.0b013e3283375974
  7. Contreras RJ, 2000, PHYSIOL BEHAV, V71, P173, DOI 10.1016/S0031-9384(00)00331-0
  8. da Silva AA, 2003, NUTR METAB CARDIOVAS, V13, P133
  9. Ding Y, 2010, J HYPERTENS, V28, P1290, DOI 10.1097/HJH.0b013e328337da8f
  10. Feber J, 2010, CLIN SCI, V119, P151, DOI 10.1042/CS20090544
  11. Giammattei CE, 1999, AM J PHYSIOL-REG I, V277, pR1230
  12. Gilbert JS, 2007, PEDIATR RES, V61, P42, DOI 10.1203/01.pdr.0000250208.09874.91
  13. Grigore D, 2007, AM J PHYSIOL-REG I, V293, pR804, DOI 10.1152/ajpregu.00725.2006
  14. Khan Imran Y., 2003, Hypertension (Baltimore), V41, P168, DOI 10.1161/01.HYP.0000047511.97879.FC
  15. Kobori H, 2007, PHARMACOL REV, V59, P251, DOI 10.1124/pr.59.3.3
  16. Koleganova N, 2011, AM J PHYSIOL-RENAL, V301, pF344, DOI 10.1152/ajprenal.00626.2010
  17. Kotsis V, 2010, HYPERTENS RES, V33, P386, DOI 10.1038/hr.2010.9
  18. Langley-Evans SC, 2003, ARCH PHYSIOL BIOCHEM, P8
  19. Leandro SM, 2008, PHYSIOL BEHAV, P5
  20. Lisle SJM, 2003, BRIT J NUTR, V90, P33, DOI 10.1079/BJN2003881
  21. McMullen S, 2005, AM J PHYSIOL-REG I, V288, pR85, DOI 10.1152/ajpregu.00435.2004
  22. Mohan S, 2009, CLIN SCI, V117, P1, DOI 10.1042/CS20080207
  23. Moritz KM, 2010, PLACENTA, V31, pS40, DOI 10.1016/j.placenta.2010.01.006
  24. Ojeda NB, 2007, HYPERTENSION, V50, P679, DOI 10.1061/HYPERTENSIONAHA.107.091785
  25. Paul M, 2006, PHYSIOL REV, V86, P747, DOI 10.1152/physrev.00036.2005
  26. Porter JP, 2007, AM J PHYSIOL-REG I, V293, pR334, DOI 10.1152/ajpregu.00887.2006
  27. Raj M, 2010, INDIAN J MED RES, V132, P598
  28. Roche HM, 2005, P NUTR SOC, V64, P371, DOI 10.1079/PNS2005445
  29. Ross MG, 2005, AM J OBSTET GYNECOL, V192, P1196, DOI 10.1016/j.ajog.2005.01.006
  30. Sarafidis PA, 2011, J CLIN HYPERTENS, V13, P523, DOI 10.1111/j.1751-7176.2011.00445.x
  31. Singh RR, 2007, J PHYSIOL-LONDON, V579, P503, DOI 10.1113/jphysiol.2006.125773
  32. Vehaskari VM, 2005, J AM SOC NEPHROL, V16, P2545, DOI 10.1681/ASN.2005030300
  33. Vikers MH, 2000, AM J PHYSIOL-ENDOC M, V279, pE83
  34. Wells JCK, 2007, BIOL REV, V82, P143, DOI 10.1111/j.1469-185X.2006.00007.x
  35. Wlodek ME, 2007, J AM SOC NEPHROL, V18, P1688, DOI 10.1681/ASN.2007010015
  36. Woods LL, 2001, PEDIATR RES, V49, P460, DOI 10.1203/00006450-200104000-00005

Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - LIM/16