Mixed uremic osteodystrophy: an ill-described common bone pathology in patients with chronic kidney disease

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorELKHOULI, Ekbal
dc.contributor.authorNAGY, Eman
dc.contributor.authorSANTOS, Cassia Gomes S.
dc.contributor.authorBARRETO, Fellype Carvalho
dc.contributor.authorCHAER, Juliana
dc.contributor.authorJORGETTI, Vanda
dc.contributor.authorEL-HUSSEINI, Amr
dc.date.accessioned2024-02-15T14:55:46Z
dc.date.available2024-02-15T14:55:46Z
dc.date.issued2023
dc.description.abstractRenal osteodystrophy (ROD) starts early and progresses with further loss of kidney function in patients with chronic kidney disease (CKD). There are four distinct types of ROD based on undecalcified bone biopsy results. Adynamic bone disease and osteomalacia are the predominant forms of low bone turnover, while hyperparathyroid bone disease and mixed uremic osteodystrophy (MUO) are typically associated with high bone turnover. MUO is a prevalent but poorly described pathology that demonstrates evidence of osteomalacia on top of the high bone formation/resorption. The prevalence of MUO ranges from 5 to 63% among different studies. The pathogenesis of MUO is multi-factorial. Altered phosphate homeostasis, hypocalcemia, vitamin D deficiency, increased FGF-23, interleukins 1 and 6, TNF-& alpha;, amyloid, and heavy metal accumulation are the main inducers of MUO. The clinical findings of MUO are usually non-specific. The use of non-invasive testing such as bone turnover markers and imaging techniques might help to suspect MUO. However, it is usually impossible to precisely diagnose this condition without performing bone biopsy. The principal management of MUO is to control the maladaptive hyperparathyroidism along with correcting any nutritional mineral deficiencies that may induce mineralization defect. MUO is a common but still poorly understood bone pathology category; it demonstrates the complexity and difficulty in understanding ROD. A large prospective bone biopsy-based studies are needed for better identification as proper diagnosis and management would improve the outcome of patients with MUO.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.description.sponsorshipAcknowledgement for ISN and USAID associations for their support.
dc.identifier.citationOSTEOPOROSIS INTERNATIONAL, v.34, n.12, p.2003-2012, 2023
dc.identifier.doi10.1007/s00198-023-06886-5
dc.identifier.eissn1433-2965
dc.identifier.issn0937-941X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/58203
dc.language.isoeng
dc.publisherSPRINGER LONDON LTDeng
dc.relation.ispartofOsteoporosis International
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright SPRINGER LONDON LTDeng
dc.subjectMixed uremic osteodystrophyeng
dc.subjectCKD-MBDeng
dc.subjectBone pathologyeng
dc.subjectrenal osteodystrophyeng
dc.subjectmanagementeng
dc.subject.otherpositron-emission-tomographyeng
dc.subject.otherrenal osteodystrophyeng
dc.subject.otherhemodialysis-patientseng
dc.subject.otherdialysis patientseng
dc.subject.othermineral densityeng
dc.subject.otheradynamic boneeng
dc.subject.otherhistomorphometryeng
dc.subject.othercalcificationseng
dc.subject.otherosteoporosiseng
dc.subject.otherpathogenesiseng
dc.subject.wosEndocrinology & Metabolismeng
dc.titleMixed uremic osteodystrophy: an ill-described common bone pathology in patients with chronic kidney diseaseeng
dc.typearticleeng
dc.type.categoryrevieweng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryEgito
hcfmusp.affiliation.countryisoeg
hcfmusp.affiliation.countryisous
hcfmusp.author.externalELKHOULI, Ekbal:Mansoura Univ, Mansoura Pathol Dept, Mansoura, Egypt
hcfmusp.author.externalNAGY, Eman:Mansoura Univ, Mansoura Nephrol & Dialysis Unit, Mansoura, Egypt
hcfmusp.author.externalSANTOS, Cassia Gomes S.:Univ Fed Parana, Dept Internal Med, Div Nephrol, Curitiba, Parana, Brazil
hcfmusp.author.externalBARRETO, Fellype Carvalho:Univ Fed Parana, Dept Internal Med, Div Nephrol, Curitiba, Parana, Brazil
hcfmusp.author.externalEL-HUSSEINI, Amr:Univ Kentucky, Div Nephrol Bone & Mineral Metab, Lexington, KY 40506 USA
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcJULIANA DA CUNHA CHAER RIBEIRO PINTO
hcfmusp.contributor.author-fmusphcVANDA JORGETTI
hcfmusp.description.beginpage2003
hcfmusp.description.endpage2012
hcfmusp.description.issue12
hcfmusp.description.volume34
hcfmusp.origemWOS
hcfmusp.origem.pubmed37658999
hcfmusp.origem.scopus2-s2.0-85169603070
hcfmusp.origem.wosWOS:001057075600001
hcfmusp.publisher.cityLONDONeng
hcfmusp.publisher.countryENGLANDeng
hcfmusp.relation.referenceAaltonen L, 2020, BONE, V134, DOI 10.1016/j.bone.2020.115267eng
hcfmusp.relation.referenceAl-beyatti Y, 2012, OSTEOPOROSIS INT, V23, P2535, DOI 10.1007/s00198-011-1889-2eng
hcfmusp.relation.referenceAlexander AJ, 2017, SEMIN DIALYSIS, V30, P361, DOI 10.1111/sdi.12598eng
hcfmusp.relation.referenceAraújo SMHA, 2003, KIDNEY INT, V63, pS54, DOI 10.1046/j.1523-1755.63.s85.13.xeng
hcfmusp.relation.referenceAsadipooya K, 2021, KIDNEY DIS-BASEL, V7, P268, DOI 10.1159/000515534eng
hcfmusp.relation.referenceAsci G, 2011, NEPHROL DIAL TRANSPL, V26, P1010, DOI 10.1093/ndt/gfq491eng
hcfmusp.relation.referenceBarreto DV, 2005, KIDNEY INT, V67, P1576, DOI 10.1111/j.1523-1755.2005.00239.xeng
hcfmusp.relation.referenceBarreto FC, 2006, KIDNEY INT, V69, P1852, DOI 10.1038/sj.ki.5000311eng
hcfmusp.relation.referenceBarreto Fellype de Carvalho, 2018, Braz. J. Nephrol., V40, P366, DOI [10.1590/2175-8239-JBN-2017-0012, 10.1590/2175-8239-jbn-2017-0012]eng
hcfmusp.relation.referenceBehets GJ, 2015, KIDNEY INT, V87, P846, DOI 10.1038/ki.2014.349eng
hcfmusp.relation.referenceBellorin-Font E, 2023, NUTRIENTS, V15, DOI 10.3390/nu15010167eng
hcfmusp.relation.referenceBembem K, 2017, INDIAN J HEMATOL BLO, V33, P603, DOI 10.1007/s12288-016-0754-zeng
hcfmusp.relation.referenceBOLING EP, 1993, BONE, V14, P409, DOI 10.1016/8756-3282(93)90172-7eng
hcfmusp.relation.referenceBrandenburg V, 2022, NUTRIENTS, V14, DOI 10.3390/nu14153009eng
hcfmusp.relation.referenceCarbonara CEM, 2023, J BRAS NEFROL, V45, P257, DOI [10.1590/2175-8239-JBN-2022-0146en, 10.1590/2175-8239-jbn-2022-0146en]eng
hcfmusp.relation.referenceCarbonara CEM, 2023, PLOS ONE, V18, DOI 10.1371/journal.pone.0284123eng
hcfmusp.relation.referenceCarbonare LD, 2021, J CLIN MED, V10, DOI 10.3390/jcm10194617eng
hcfmusp.relation.referenceChaer J., 2023, ROLE OSTEOCYTE UNPUBeng
hcfmusp.relation.referenceChavassieux P, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.907914eng
hcfmusp.relation.referenceCheung AM, 2013, CURR OSTEOPOROS REP, V11, P136, DOI 10.1007/s11914-013-0140-9eng
hcfmusp.relation.referenceClarke BL, 1996, J CLIN ENDOCR METAB, V81, P2264, DOI 10.1210/jc.81.6.2264eng
hcfmusp.relation.referenceDempster DW, 2013, J BONE MINER RES, V28, P1, DOI 10.1002/jbmr.1805eng
hcfmusp.relation.referenceDEVITA MV, 1992, MEDICINE, V71, P284, DOI 10.1097/00005792-199209000-00003eng
hcfmusp.relation.referenceDos Reis LM, 2007, J BONE MINER METAB, V25, P400, DOI 10.1007/s00774-007-0778-4eng
hcfmusp.relation.referenceDrüeke TB, 2016, KIDNEY INT, V89, P289, DOI 10.1016/j.kint.2015.12.004eng
hcfmusp.relation.referenceElder G, 2002, J BONE MINER RES, V17, P2094, DOI 10.1359/jbmr.2002.17.12.2094eng
hcfmusp.relation.referenceEven-Sapir E, 2007, SEMIN NUCL MED, V37, P462, DOI 10.1053/j.semnuclmed.2007.07.002eng
hcfmusp.relation.referenceEvenepoel P, 2017, J NEPHROL, V30, P645, DOI 10.1007/s40620-017-0424-8eng
hcfmusp.relation.referenceFerreira AC, 2021, CALCIFIED TISSUE INT, V108, P528, DOI 10.1007/s00223-021-00838-zeng
hcfmusp.relation.referenceFletcher S, 1997, NEPHRON, V75, P412, DOI 10.1159/000189578eng
hcfmusp.relation.referenceFRAME B, 1978, ANN INTERN MED, V89, P966, DOI 10.7326/0003-4819-89-6-966eng
hcfmusp.relation.referenceFrost ML, 2013, CALCIFIED TISSUE INT, V93, P436, DOI 10.1007/s00223-013-9778-7eng
hcfmusp.relation.referenceFukumoto S, 2015, J BONE MINER METAB, V33, P467, DOI 10.1007/s00774-015-0698-7eng
hcfmusp.relation.referenceFusaro M, 2022, NUTRIENTS, V14, DOI 10.3390/nu14091742eng
hcfmusp.relation.referenceGerakis A, 2000, J NEPHROL, V13, P437eng
hcfmusp.relation.referenceHaarhaus M, 2021, KIDNEY INT, V100, P546, DOI 10.1016/j.kint.2021.04.043eng
hcfmusp.relation.referenceHo LT, 2002, SEMIN NEPHROL, V22, P488, DOI 10.1053/snep.2002.35965eng
hcfmusp.relation.referenceHodler J, 2021, DIAGN IMAGINGeng
hcfmusp.relation.referenceHRUSKA KA, 1995, NEW ENGL J MED, V333, P166, DOI 10.1056/NEJM199507203330307eng
hcfmusp.relation.referenceKeronen S, 2016, CLIN NEPHROL, V85, P127, DOI 10.5414/CN108709eng
hcfmusp.relation.referenceKetteler M, 2017, KIDNEY INT, V92, P26, DOI 10.1016/j.kint.2017.04.006eng
hcfmusp.relation.referenceKidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Work Group, 2009, Kidney Int Suppl, pS1, DOI 10.1038/ki.2009.188eng
hcfmusp.relation.referenceLaowalert S, 2020, NEPHROLOGY, V25, P163, DOI 10.1111/nep.13593eng
hcfmusp.relation.referenceLavigne F, 2021, J NEPHROL, V34, P901, DOI 10.1007/s40620-020-00798-xeng
hcfmusp.relation.referenceLegan M., 2005, THER APHER DIAL, V9, P80, DOI [10.1111/j.1526-0968.2005.222_8_8.x, DOI 10.1111/J.1526-0968.2005.222_8_8.X]eng
hcfmusp.relation.referenceLegg V, 2005, AM J NURS, V105, P40, DOI 10.1097/00000446-200506000-00024eng
hcfmusp.relation.referenceLehmann G, 2007, TRANSPL P, V39, P3153, DOI 10.1016/j.transproceed.2007.10.001eng
hcfmusp.relation.referenceLima F, 2014, CLIN NEPHROL, V82, P287, DOI 10.5414/CN108407eng
hcfmusp.relation.referenceLondon GM, 2004, J AM SOC NEPHROL, V15, P1943, DOI 10.1097/01.asn.0000129337.50739.48eng
hcfmusp.relation.referenceMALLUCHE H, 1990, KIDNEY INT, V38, P193, DOI 10.1038/ki.1990.187eng
hcfmusp.relation.referenceMalluche HH, 1986, ATLAS MINERALIZED BO, V136eng
hcfmusp.relation.referenceMisiorowski W, 2017, ENDOCRINE, V58, P380, DOI 10.1007/s12020-017-1414-2eng
hcfmusp.relation.referenceMoe S, 2006, KIDNEY INT, V69, P1945, DOI 10.1038/sj.ki.5000414eng
hcfmusp.relation.referenceMoe SM, 2008, J AM SOC NEPHROL, V19, P213, DOI 10.1681/ASN.2007080854eng
hcfmusp.relation.referenceNagy E, 2022, J CLIN MED, V11, DOI 10.3390/jcm11237130eng
hcfmusp.relation.referenceNational Kidney Foundation, 2003, AM J KIDNEY DIS, V42, pS1, DOI 10.1016/S0272-6386(03)00905-3eng
hcfmusp.relation.referenceNeto R, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0258284eng
hcfmusp.relation.referenceNovel-Catin E, 2020, BONE, V138, DOI 10.1016/j.bone.2020.115460eng
hcfmusp.relation.referencePothuaud L, 2008, BONE, V42, P775, DOI 10.1016/j.bone.2007.11.018eng
hcfmusp.relation.referenceREHMAN MTA, 1994, J CLIN PATHOL, V47, P529, DOI 10.1136/jcp.47.6.529eng
hcfmusp.relation.referenceSantos MFP, 2019, J BONE MINER METAB, V37, P125, DOI 10.1007/s00774-018-0902-7eng
hcfmusp.relation.referenceSchober HC, 1998, J AM SOC NEPHROL, V9, P1225eng
hcfmusp.relation.referenceSchonland SO, 2008, HAEMATOLOGICA, V93, P955, DOI 10.3324/haematol.12497eng
hcfmusp.relation.referenceSlatopolsky E, 2003, BLOOD PURIFICAT, V21, P318, DOI 10.1159/000072552eng
hcfmusp.relation.referenceUchida H, 2010, TOXICOL PATHOL, V38, P730, DOI 10.1177/0192623310374328eng
hcfmusp.relation.referenceWest SL, 2015, J BONE MINER RES, V30, P913, DOI 10.1002/jbmr.2406eng
hcfmusp.relation.referenceZhang SP, 2020, ADV SCI, V7, DOI 10.1002/advs.202000383eng
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