Strongyloides infection screening in transplant candidates: What is the best strategy?

dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorGRYSCHEK, Ronaldo Cesar Borges
dc.contributor.authorCORRAL, Marcelo Andreetta
dc.contributor.authorSITTA, Renata Barnabe
dc.contributor.authorGOTTARDI, Maiara
dc.contributor.authorPIERROTTI, Ligia Camera
dc.contributor.authorCOSTA, Silvia Figueiredo
dc.contributor.authorABDALA, Edson
dc.contributor.authorCHIEFFI, Pedro Paulo
dc.contributor.authorPAULA, Fabiana Martins de
dc.date.accessioned2024-02-15T14:47:44Z
dc.date.available2024-02-15T14:47:44Z
dc.date.issued2023
dc.description.abstractBackground: The potential that Strongyloides stercoralis infection has to cause major morbidity and high mortality when the disseminated form occurs in transplant patients is of particular concern.Methods: In this study, the objective was to observe S. stercoralis infection in patients who are candidates for transplantation by using parasitological, serological, and molecular techniques and to propose an algorithm for the detection of that infection in transplant candidates.Results: By parasitological techniques, 10% of fecal samples were positive. Anti-Strongyloides antibodies immunoglobulin G were detected in 19.3% and 20.7% of patients by immunofluorescence assay and enzyme-linked immunosorbent assay, respectively. S. stercoralis DNA was observed in 17.3% of samples by conventional polymerase chain reaction and 32.7% of samples by quantitative polymerase chain reaction (qPCR).Conclusion: The set of results allows us to reinforce that a positive result by parasitological techniques and/or qPCR indicates that the specific treatment should be applied. However, the improvement of diagnostic techniques may suggest changes in the screening for strongyloidiasis in these patients. imageeng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.description.sponsorshipFundacao de Amparo a Pesquisa do EStado de Sao Paulo (FAPESP) [2010/51110-2, 2013/04236-9]
dc.identifier.citationTRANSPLANT INFECTIOUS DISEASE, v.25, n.6, 2023
dc.identifier.doi10.1111/tid.14153
dc.identifier.eissn1399-3062
dc.identifier.issn1398-2273
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/57945
dc.language.isoeng
dc.publisherWILEYeng
dc.relation.ispartofTransplant Infectious Disease
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright WILEYeng
dc.subjectdiagnosis methodseng
dc.subjectStrongyloides infectioneng
dc.subjecttransplant candidateseng
dc.subject.otherreal-time pcreng
dc.subject.othermolecular diagnosiseng
dc.subject.otherhyperinfection syndromeeng
dc.subject.otherdrug-resistanceeng
dc.subject.otherendemic areaeng
dc.subject.otherstercoraliseng
dc.subject.othervenezuelensiseng
dc.subject.othersampleseng
dc.subject.otherimmunodiagnosiseng
dc.subject.otherantigenseng
dc.subject.wosImmunologyeng
dc.subject.wosInfectious Diseaseseng
dc.subject.wosTransplantationeng
dc.titleStrongyloides infection screening in transplant candidates: What is the best strategy?eng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalSITTA, Renata Barnabe:Univ Sao Paulo, Hosp Clin, Fac Med, Lab Invest Med LIM 06, Sao Paulo, Brazil
hcfmusp.author.externalCHIEFFI, Pedro Paulo:Fac Ciencias Med Santa Casa Misericordia Sao Paulo, Sao Paulo, Brazil
hcfmusp.citation.scopus1
hcfmusp.contributor.author-fmusphcRONALDO CESAR BORGES GRYSCHEK
hcfmusp.contributor.author-fmusphcMARCELO ANDREETTA CORRAL
hcfmusp.contributor.author-fmusphcMAIARA GOTTARDI
hcfmusp.contributor.author-fmusphcLIGIA CAMERA PIERROTTI
hcfmusp.contributor.author-fmusphcSILVIA FIGUEIREDO COSTA
hcfmusp.contributor.author-fmusphcEDSON ABDALA
hcfmusp.contributor.author-fmusphcFABIANA MARTINS DE PAULA
hcfmusp.description.issue6
hcfmusp.description.volume25
hcfmusp.origemWOS
hcfmusp.origem.pubmed37750481
hcfmusp.origem.scopus2-s2.0-85172128901
hcfmusp.origem.wosWOS:001073559200001
hcfmusp.publisher.cityHOBOKENeng
hcfmusp.publisher.countryUSAeng
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