GREB1 tissue expression is associated with organ-confined prostate cancer

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorANTUNES, Alberto A.
dc.contributor.authorLEITE, Katia R.
dc.contributor.authorREIS, Sabrina T.
dc.contributor.authorSOUSA-CANAVEZ, Juliana M.
dc.contributor.authorCAMARA-LOPES, Luiz H.
dc.contributor.authorDALL'OGLIO, Marcos F.
dc.contributor.authorSROUGI, Miguel
dc.date.accessioned2013-07-30T14:39:12Z
dc.date.available2013-07-30T14:39:12Z
dc.date.issued2012
dc.description.abstractObjective: By reason of its heterogeneous behavior, it is difficult to determine the prognosis of many prostate cancer cases. Patients with the same clinicopathologic conditions may present varying clinical findings and rates of progression. We determined the role of new genes as potential molecular markers for prostate cancer prognosis. Materials and methods: We performed a microarray analysis of two pools of patients with prostate cancer divided according to their clinicopathologic characteristics. After that, we validated these results by testing the genes with most different expressions between the two pools using the quantitative real time polymerase chain reaction method. We analyzed gene expression in 33 patients with localized prostate cancer according to prostate specific antigen (PSA), pathologic stage, Gleason score, and biochemical recurrence. For statistical analysis we used the Mann-Whitney Test. Results: The microarray analysis revealed that 4,147 genes presented a different expression between the two pools. Among them, 3 genes, TMEFF2, GREB1, and THIL,, were at least 13-times overexpressed, and 1 gene, IGH3, which was at least 5times under-expressed in pool 1 (good prognosis) compared with pool 2 (bad prognosis), were selected for analysis. After the validation tests, GREB1 was significantly more overexpressed among patients with stage T2 compared with T3 (P = 0.020). The expressions of other 3 genes did not present significant differences according to the clinicopatholoOcal variables. Conclusions: Tissue expression of GREB1 is associated with organ-confined prostate cancer and may constitute a gene associated with a favorable prognosis.
dc.description.indexMEDLINE
dc.identifier.citationUROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, v.30, n.1, p.16-20, 2012
dc.identifier.doi10.1016/j.urolonc.2009.09.014
dc.identifier.issn1078-1439
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/385
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofUrologic Oncology-Seminars and Original Investigations
dc.rightsrestrictedAccess
dc.rights.holderCopyright ELSEVIER SCIENCE INC
dc.subjectProstate
dc.subjectProstate neoplasms
dc.subjectBiopsy
dc.subjectPrognosis
dc.subjectGene expression
dc.subjectGREB1
dc.subject.otherpredict pathological stage
dc.subject.otherclinical stage
dc.subject.othergleason score
dc.subject.othercarcinoma
dc.subject.otherregulator
dc.subject.otherantigen
dc.subject.othergrowth
dc.subject.wosOncology
dc.subject.wosUrology & Nephrology
dc.titleGREB1 tissue expression is associated with organ-confined prostate cancer
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalSOUSA-CANAVEZ, Juliana M.:Genoa Biotechnol SA, Alameda Ministro Rocha Azevedo, Sao Paulo, Brazil
hcfmusp.author.externalCAMARA-LOPES, Luiz H.:Genoa Biotechnol SA, Alameda Ministro Rocha Azevedo, Sao Paulo, Brazil
hcfmusp.citation.scopus4
hcfmusp.contributor.author-fmusphcALBERTO AZOUBEL ANTUNES
hcfmusp.contributor.author-fmusphcKATIA RAMOS MOREIRA LEITE
hcfmusp.contributor.author-fmusphcSABRINA THALITA DOS REIS FARIA
hcfmusp.contributor.author-fmusphcMARCOS FRANCISCO DALL'OGLIO
hcfmusp.contributor.author-fmusphcMIGUEL SROUGI
hcfmusp.description.beginpage16
hcfmusp.description.endpage20
hcfmusp.description.issue1
hcfmusp.description.volume30
hcfmusp.lim.ref2012
hcfmusp.origemWOS
hcfmusp.origem.pubmed19945309
hcfmusp.origem.scopus2-s2.0-84855681350
hcfmusp.origem.wosWOS:000299607700003
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
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hcfmusp.scopus.lastupdate2024-05-17
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