The Risk of Reinfection or Primary Hepatitis E Virus Infection at a Liver Transplant Center in Brazil: An Observational Cohort Study

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorZICKER, Michelle
dc.contributor.authorPINHO, Joao R. R.
dc.contributor.authorWELTER, Eliane A. R.
dc.contributor.authorGUARDIA, Bianca D.
dc.contributor.authorSILVA, Paulo G. T. M. da
dc.contributor.authorSILVEIRA, Leonardo B. da
dc.contributor.authorCAMARGO, Luis F. A.
dc.date.accessioned2024-04-05T19:36:28Z
dc.date.available2024-04-05T19:36:28Z
dc.date.issued2024
dc.description.abstractThe hepatitis E virus is a major etiological agent of chronic hepatitis in immunosuppressed individuals. Seroprevalence in the liver transplantation setting varies according to the seroprevalence of the general population in different countries. This was a prospective cohort study of liver transplant recipients in southeastern Brazil. Recipients were systematically followed for one year, with the objective of determining the prevalence, incidence, and natural history of HEV infection in this population. We included 107 liver transplant recipients and 83 deceased donors. Positivity for anti-HEV IgG was detected in 10.2% of the recipients and in 9.7% of the donors. None of the patients tested positive for HEV RNA at baseline or during follow-up. There were no episodes of reactivation or seroconversion, even in cases of serological donor-recipient mismatch or in recipients with acute hepatitis. Acute and chronic HEV infections seem to be rare events in the region studied. That could be attributable to social, economic, and environmental factors. Our data indicate that, among liver transplant recipients, hepatitis E should be investigated only when there are elevated levels of transaminases with no defined cause, as part of the differential diagnosis of seronegative hepatitis after transplantation.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexScopus
dc.description.indexDimensions
dc.description.indexWoS
dc.description.sponsorshipSo Paulo Research Foundation
dc.identifier.citationVIRUSES-BASEL, v.16, n.2, article ID 301, 12p, 2024
dc.identifier.doi10.3390/v16020301
dc.identifier.eissn1999-4915
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/59097
dc.language.isoeng
dc.publisherMDPIeng
dc.relation.ispartofViruses-Basel
dc.rightsopenAccesseng
dc.rights.holderCopyright MDPIeng
dc.subjecthepatitis Eeng
dc.subjectliver transplantationeng
dc.subjectprevalenceeng
dc.subjectincidenceeng
dc.subjectnatural historyeng
dc.subjectBrazileng
dc.subject.otherhev infectioneng
dc.subject.other1st reporteng
dc.subject.otherrecipientseng
dc.subject.otherreactivationeng
dc.subject.otherprevalenceeng
dc.subject.otherenzymeseng
dc.subject.wosVirologyeng
dc.titleThe Risk of Reinfection or Primary Hepatitis E Virus Infection at a Liver Transplant Center in Brazil: An Observational Cohort Studyeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalZICKER, Michelle:Univ Fed Sao Paulo, Dept Internal Med, Div Infect Dis, BR-04023062 Sao Paulo, Brazil
hcfmusp.author.externalPINHO, Joao R. R.:Hosp Israelita Albert Einstein, Clin Lab, Res & Dev Sect, BR-05652900 Sao Paulo, Brazil
hcfmusp.author.externalWELTER, Eliane A. R.:Hosp Israelita Albert Einstein, Clin Lab, Res & Dev Sect, BR-05652900 Sao Paulo, Brazil
hcfmusp.author.externalGUARDIA, Bianca D.:Hosp Israelita Albert Einstein, Liver Transplant Program, BR-05652900 Sao Paulo, Brazil
hcfmusp.author.externalSILVA, Paulo G. T. M. da:Fac Israelita Ciencias Saude Albert Einstein, BR-05653120 Sao Paulo, Brazil
hcfmusp.author.externalSILVEIRA, Leonardo B. da:Fac Israelita Ciencias Saude Albert Einstein, BR-05653120 Sao Paulo, Brazil
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcLUIS FERNANDO ARANHA CAMARGO
hcfmusp.description.articlenumber301
hcfmusp.description.issue2
hcfmusp.description.volume16
hcfmusp.origemWOS
hcfmusp.origem.dimensionspub.1169042174
hcfmusp.origem.pubmed38400077
hcfmusp.origem.scopus2-s2.0-85185969427
hcfmusp.origem.wosWOS:001168457400001
hcfmusp.publisher.cityBASELeng
hcfmusp.publisher.countrySWITZERLANDeng
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