Absence of Plasmodium falciparum K13 Propeller Domain Polymorphisms among Field Isolates Collected from the Brazilian Amazon Basin between 1984 and 2011

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorINOUE, Juliana
dc.contributor.authorJOVEL, Irina
dc.contributor.authorMORRIS, Ulrika
dc.contributor.authorAYDIN-SCHMIDT, Berit
dc.contributor.authorISLAM, Atiqul
dc.contributor.authorSEGURADO, Aluisio Cotrim
dc.contributor.authorBJORKMAN, Anders
dc.contributor.authorSANTI, Silvia Di
dc.contributor.authorMARTENSSON, Andreas
dc.date.accessioned2019-01-17T13:33:13Z
dc.date.available2019-01-17T13:33:13Z
dc.date.issued2018
dc.description.abstractArtemisinin resistance, presently confined to Southeast Asia and associated with mutations in the Plasmodium falciparum K13 (PfK13) propeller domain, represents a serious threat to global malaria control. This study aimed to provide baseline information for future artemisinin resistance surveillance, by analyzing the PfK13 propeller domain in P. falciparum field isolates collected from the Brazilian Amazon Basin between 1984 and 2011. A total of 152 P. falciparum mono-infections were assessed, of which 118 (78%) were collected before and 34 (22%) after the introduction of artemisinin-based combination therapy (ACT) in 2006. An 849-base pair fragment encoding the PfK13 propeller was amplified by nested polymerase chain reaction and sequenced in both directions. The sequences were compared with the reference sequence of P. falciparum 3D7. All samples showed wild-type sequences, thus, no mutations were observed. The results are in agreement with other recent reports and do not provide evidence for presence of PfK13 propeller domain polymorphisms associated with artemisinin resistance among P. falciparum field isolates in the Brazilian Amazon Basin neither before nor after the implementation of ACT.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipEuroInkaNet Project/Erasmus Mundus Programme [2011/07380-8 FAPESP]
dc.identifier.citationAMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, v.99, n.6, p.1504-1507, 2018
dc.identifier.doi10.4269/ajtmh.18-0554
dc.identifier.eissn1476-1645
dc.identifier.issn0002-9637
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/29939
dc.language.isoeng
dc.publisherAMER SOC TROP MED & HYGIENEeng
dc.relation.ispartofAmerican Journal of Tropical Medicine and Hygiene
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright AMER SOC TROP MED & HYGIENEeng
dc.subject.otherartemisinin resistanceeng
dc.subject.othermalariaeng
dc.subject.wosPublic, Environmental & Occupational Healtheng
dc.subject.wosTropical Medicineeng
dc.titleAbsence of Plasmodium falciparum K13 Propeller Domain Polymorphisms among Field Isolates Collected from the Brazilian Amazon Basin between 1984 and 2011eng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countrySuécia
hcfmusp.affiliation.countryisose
hcfmusp.author.externalINOUE, Juliana:Uppsala Univ, Dept Womens & Childrens Hlth, Int Maternal & Child Hlth, MTC Huset,Dag Hammarskjolds Vag 14B,2 Tr, S-75237 Uppsala, Sweden
hcfmusp.author.externalJOVEL, Irina:Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Ctr Malaria Res, Stockholm, Sweden
hcfmusp.author.externalMORRIS, Ulrika:Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Ctr Malaria Res, Stockholm, Sweden
hcfmusp.author.externalAYDIN-SCHMIDT, Berit:Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Ctr Malaria Res, Stockholm, Sweden
hcfmusp.author.externalISLAM, Atiqul:Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Ctr Malaria Res, Stockholm, Sweden
hcfmusp.author.externalBJORKMAN, Anders:Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Ctr Malaria Res, Stockholm, Sweden
hcfmusp.author.externalMARTENSSON, Andreas:Uppsala Univ, Dept Womens & Childrens Hlth, Int Maternal & Child Hlth, MTC Huset,Dag Hammarskjolds Vag 14B,2 Tr, S-75237 Uppsala, Sweden
hcfmusp.citation.scopus5
hcfmusp.contributor.author-fmusphcALUISIO AUGUSTO COTRIM SEGURADO
hcfmusp.contributor.author-fmusphcSILVIA MARIA FATIMA DI SANTI
hcfmusp.description.beginpage1504
hcfmusp.description.endpage1507
hcfmusp.description.issue6
hcfmusp.description.volume99
hcfmusp.origemWOS
hcfmusp.origem.pubmed30277206
hcfmusp.origem.scopus2-s2.0-85058165678
hcfmusp.origem.wosWOS:000452400500025
hcfmusp.publisher.cityMCLEANeng
hcfmusp.publisher.countryUSAeng
hcfmusp.relation.referenceAriey F, 2014, NATURE, V505, P50, DOI 10.1038/nature12876eng
hcfmusp.relation.referenceChenet SM, 2016, J INFECT DIS, V213, P1472, DOI 10.1093/infdis/jiv752eng
hcfmusp.relation.referenceDondorp AM, 2009, NEW ENGL J MED, V361, P455, DOI 10.1056/NEJMoa0808859eng
hcfmusp.relation.referenceDuarte EC, 1996, AM J TROP MED HYG, V54, P197, DOI 10.4269/ajtmh.1996.54.197eng
hcfmusp.relation.referenceFerreira MU, 2016, MALARIA J, V15, DOI 10.1186/s12936-016-1335-1eng
hcfmusp.relation.referenceHuang F, 2015, J INFECT DIS, V212, P1629, DOI 10.1093/infdis/jiv249eng
hcfmusp.relation.referenceKyaw MP, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057689eng
hcfmusp.relation.referenceLadeia-Andrade S, 2016, AM J TROP MED HYG, V95, P148, DOI 10.4269/ajtmh.16-0017eng
hcfmusp.relation.referenceMenard D, 2016, NEW ENGL J MED, V374, P2453, DOI 10.1056/NEJMoa1513137eng
hcfmusp.relation.referenceMinistry of Health of Brazil, 2018, B MALeng
hcfmusp.relation.referenceMinistry of Health of Brazil, 2010, GUIA PRAT TRAT MAL Beng
hcfmusp.relation.referenceMita T, 2016, ANTIMICROB AGENTS CH, V60, P3340, DOI 10.1128/AAC.02370-15eng
hcfmusp.relation.referenceMita T, 2011, J INFECT DIS, V204, P1980, DOI 10.1093/infdis/jir664eng
hcfmusp.relation.referenceMita T, 2010, ACTA TROP, V114, P166, DOI 10.1016/j.actatropica.2009.07.008eng
hcfmusp.relation.referenceMusset L, 2014, MEM I OSWALDO CRUZ, V109, P525, DOI 10.1590/0074-0276140031eng
hcfmusp.relation.referencePhyo AP, 2012, LANCET, V379, P1960, DOI 10.1016/S0140-6736(12)60484-Xeng
hcfmusp.relation.referencePribluda VS, 2014, MALARIA J, V13, DOI 10.1186/1475-2875-13-77eng
hcfmusp.relation.referenceSantelli AC, 2012, MALARIA J, V11, DOI 10.1186/1475-2875-11-286eng
hcfmusp.relation.referenceStraimer J, 2015, SCIENCE, V347, P428, DOI 10.1126/science.1260867eng
hcfmusp.relation.referenceHien TT, 2012, MALARIA J, V11, DOI 10.1186/1475-2875-11-355eng
hcfmusp.relation.referenceVreden SGS, 2013, MEM I OSWALDO CRUZ, V108, P968, DOI 10.1590/0074-0276130167eng
hcfmusp.relation.referenceWellems TE, 2009, J CLIN INVEST, V119, P2496, DOI 10.1172/JCI38307eng
hcfmusp.relation.referenceWHO, 2017, ART ART BAS COMB THEeng
hcfmusp.relation.referenceWOODEN J, 1993, PARASITOL TODAY, V9, P303, DOI 10.1016/0169-4758(93)90131-Xeng
hcfmusp.relation.referenceWorld Health Organization, 2015, STAT REP ART ACT RESeng
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