MMP-1 promoter polymorphism is associated with primary tendinopathy of the posterior tibial tendon
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Citações na Scopus
28
Tipo de produção
article
Data de publicação
2013
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY-BLACKWELL
Autores
CUNHA, Mirella V.
SANTOS, Maria Cristina L. G. dos
Citação
JOURNAL OF ORTHOPAEDIC RESEARCH, v.31, n.7, p.1103-1107, 2013
Resumo
Posterior tibial tendon (PTT) dysfunction is recognized as an etiology leading to acquired flatfoot in adults, causing significant functional loss. Many risk factors and systemic conditions have been proposed in literature. However, many patients present PTT dysfunction without any of these characteristics. This suggests that there could be a genetic influence associated with posterior tibial tendinopathy. The purpose of the present study is to investigate the association of the 1607 polymorphism in the promoter gene of MMP-1 and posterior tibial tendinopathy. The test group included 50 women, who presented PTT dysfunction grade 2 or 3, and who were submitted to surgical treatment, with histopathological examination of the tendon and magnetic resonance image (MRI) confirming tendinopathy, while the control group was 100 asymptomatic women who presented intact PTT at MRI. The results were analyzed using the chi-square test. The data showed a 75% incidence of the allele 1G and 62% of the genotype 1G/1G at the control group while, at the test group, they showed a 78% incidence of the allele 2G and 72% of the genotype 2G/2G (p<0.001). The 1607 polymorphism of promoter gene of MMP-1 is associated with the posterior tibial tendinopathy in the studied population. (c) 2013 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 31:11031107, 2013
Palavras-chave
posterior tibial tendon, tendinopathy, polymorphism, MMP-1, risk factor
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