Visceral adipose tissue in granulomatosis with polyangiitis: association with disease activity parameters
Carregando...
Citações na Scopus
1
Tipo de produção
article
Data de publicação
2021
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER LONDON LTD
Citação
CLINICAL RHEUMATOLOGY, v.40, n.7, p.2835-2841, 2021
Resumo
Objective To assess the body composition (BC) of patients with granulomatosis with polyangiitis (GPA) compared to healthy controls, emphasizing visceral adipose tissue (VAT) and associated BC parameters with disease activity, the damage index, and inflammatory parameters in patients with GPA. Methods This study was conducted in 43 patients with GPA and 43 healthy controls matched by sex, age, and body mass index (BMI). BC was analyzed using dual-energy X-ray absorptiometry (DXA). The fat mass parameters evaluated were total fat mass (FM), adiposity (%), the fat mass index (FMI: fat mass/ht(2)), and VAT (g, cm(2), cm(3)). Disease activity was assessed by the Birmingham Vasculitis Activity Score (BVAS). Damage was assessed by the Vasculitis Damage Index (VDI). C-reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) were measured. Results Comparing patients with GPA with healthy controls, patients had a significantly greater VAT (VAT in g: 685.81 +/- 306.10 vs. 581.21 +/- 235.57, p = 0.04; VAT in cm(2): 142.23 +/- 63.48 vs. 119.84 +/- 49.54, p = 0.03; VAT in cm(3): 741.33 +/- 330.97 vs. 628.44 +/- 254.66, p = 0.04). Patients with higher VAT (>= 768 g) had an increased value of ESR (22.77 +/- 26.79 vs. 11.57 +/- 11.30 mm/1st hour, p = 0.04) and an increased value of BVAS (3.18 +/- 4.15 vs. 0.90 +/- 1.70, p = 0.01) when compared to patients with less VAT (< 768 g). Conclusion Patients with GPA have altered BC compared to healthy controls. Moreover, higher VAT was associated with disease activity and higher inflammatory markers, suggesting a relationship between GPA activity and adiposity parameters.
Palavras-chave
Adipose tissue, ANCA vasculitis, Body composition, Granulomatosis with polyangiitis, Inflammatory markers
Referências
- Ahn Sung Soo, 2020, Korean J Intern Med, DOI 10.3904/kjim.2020.064
- Alexopoulos N, 2014, ATHEROSCLEROSIS, V233, P104, DOI 10.1016/j.atherosclerosis.2013.12.023
- Blumberg Max J, 2017, BMJ Case Rep, V2017, DOI 10.1136/bcr-2016-218030
- Delgado-Frias E, 2015, CLIN EXP RHEUMATOL, V33, P516
- Exley AR, 1997, ARTHRITIS RHEUM, V40, P371, DOI 10.1002/art.1780400222
- Flossmann O, 2011, ANN RHEUM DIS, V70, P488, DOI 10.1136/ard.2010.137778
- George MD, 2017, ARTHRIT CARE RES, V69, P1789, DOI 10.1002/acr.23229
- Giles JT, 2008, ARTHRITIS RHEUM, V58, P2632, DOI 10.1002/art.23766
- Giles JT, 2008, ARTHRIT RHEUM-ARTHR, V59, P807, DOI 10.1002/art.23719
- GRONHAGENRISKA C, 1993, ADV EXP MED BIOL, V336, P337
- Ibrahim MM, 2010, OBES REV, V11, P11, DOI 10.1111/j.1467-789X.2009.00623.x
- JENSEN MD, 1995, AM J CLIN NUTR, V61, P274, DOI 10.1093/ajcn/61.2.274
- Kuznetsova E, 2013, ANN RHEUM DIS, V72, P642
- Le Jemtel TH, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0880-0
- LEAVITT RY, 1990, ARTHRITIS RHEUM, V33, P1101, DOI 10.1002/art.1780330807
- Luqmani R, 2011, RHEUMATOLOGY, V50, P697, DOI 10.1093/rheumatology/keq351
- Lutalo PMK, 2014, J AUTOIMMUN, V48-49, P94, DOI 10.1016/j.jaut.2014.01.028
- Mantel A, 2015, ARTHRITIS RHEUMATOL, V67, P2845, DOI 10.1002/art.39267
- NAKAMURA T, 1994, ATHEROSCLEROSIS, V107, P239, DOI 10.1016/0021-9150(94)90025-6
- Navarro-Millan I, 2016, ANN RHEUM DIS, V75, P341, DOI 10.1136/annrheumdis-2013-204987
- Ozer Gokaslan C, 2020, TURK J MED SCI, V50, P44, DOI 10.3906/sag-1908-138
- Seo P, 2004, AM J MED, V117, P39, DOI 10.1016/j.amjmed.2004.02.030
- Stone JH, 2001, ARTHRITIS RHEUM, V44, P912, DOI 10.1002/1529-0131(200104)44:4<912::AID-ANR148>3.0.CO;2-5
- VANDERWOUDE FJ, 1985, LANCET, V1, P425
- Wallace ZS, 2017, ARTHRIT CARE RES, V69, P1004, DOI 10.1002/acr.23099
- Westhovens R, 1997, BRIT J RHEUMATOL, V36, P444
- Zhang J, 2014, POSTGRAD MED J, V90, P1301, DOI 10.1136/postgradmedj-2013-204715rep