Obesity Treatment with Botulinum Toxin-A Is Not Effective: a Systematic Review and Meta-Analysis

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorBUSTAMANTE, Fabio
dc.contributor.authorBRUNALDI, Vitor Ottoboni
dc.contributor.authorBERNARDO, Wanderley Marques
dc.contributor.authorMOURA, Diogo Turiani H. de
dc.contributor.authorMOURA, Eduardo Turiani H. de
dc.contributor.authorGALVAO, Manoel
dc.contributor.authorSANTO, Marco Aurelio
dc.contributor.authorMOURA, Eduardo Guimares H. de
dc.date.accessioned2017-10-24T13:17:59Z
dc.date.available2017-10-24T13:17:59Z
dc.date.issued2017
dc.description.abstractThe effectiveness of gastric injections of botulinum toxin-A (BTA) as primary treatment for obesity is not well known since results in literature are discrepant. Hence, we aimed to systematically review and meta-analyze the available data to assess the real effect of BTA therapy. We searched MEDLINE, Embase, Cochrane, SCOPUS, EBSCO, LILACS, and BVS. We considered eligible only randomized controlled trials enrolling obese patients comparing BTA versus saline injections. Our initial search identified 8811 records. Six studies fulfilled eligibility criteria. After critical appraisal, two articles were excluded and we meta-analyzed the remainder. The mean difference for absolute weight loss and BMI reduction were 0.12 [CI 95%, - 1.14, 1.38] and - 0.06 [95% CI, - 0.92, 0.81], respectively. Therefore, we concluded that treatment of obesity with BTA is not effective.
dc.description.indexMEDLINE
dc.identifier.citationOBESITY SURGERY, v.27, n.10, p.2716-2723, 2017
dc.identifier.doi10.1007/s11695-017-2857-5
dc.identifier.eissn1708-0428
dc.identifier.issn0960-8923
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/21901
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofObesity Surgery
dc.rightsrestrictedAccess
dc.rights.holderCopyright SPRINGER
dc.subjectObesity
dc.subjectBotulinum toxins
dc.subjectEndoscopy
dc.subjectGastric emptying
dc.subjectSystematic review
dc.subjectMeta-analysis
dc.subject.otherintragastric balloon
dc.subject.otherclinical-practice
dc.subject.othergastric distension
dc.subject.othermorbid-obesity
dc.subject.otherweight-loss
dc.subject.otherinjection
dc.subject.othermanagement
dc.subject.otherefficacy
dc.subject.othersurgery
dc.subject.otheradults
dc.subject.wosSurgery
dc.titleObesity Treatment with Botulinum Toxin-A Is Not Effective: a Systematic Review and Meta-Analysis
dc.typearticle
dc.type.categoryreview
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalGALVAO, Manoel:Gastro Obeso Ctr, Unit Endoscopy, Barata Ribeiro St 237, Sao Paulo, Brazil
hcfmusp.citation.scopus33
hcfmusp.contributor.author-fmusphcFABIO ALBERTO CASTILLO BUSTAMANTE
hcfmusp.contributor.author-fmusphcVITOR OTTOBONI BRUNALDI
hcfmusp.contributor.author-fmusphcWANDERLEY MARQUES BERNARDO
hcfmusp.contributor.author-fmusphcDIOGO TURIANI HOURNEAUX DE MOURA
hcfmusp.contributor.author-fmusphcEDUARDO TURIANI HOURNEAUX DE MOURA
hcfmusp.contributor.author-fmusphcMARCO AURELIO SANTO
hcfmusp.contributor.author-fmusphcEDUARDO GUIMARAES HOURNEAUX DE MOURA
hcfmusp.description.beginpage2716
hcfmusp.description.endpage2723
hcfmusp.description.issue10
hcfmusp.description.volume27
hcfmusp.origemWOS
hcfmusp.origem.pubmed28812212
hcfmusp.origem.scopus2-s2.0-85028549742
hcfmusp.origem.wosWOS:000411373000035
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
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hcfmusp.scopus.lastupdate2024-04-18
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