Immunopathological aspects of schistosomiasis-associated pulmonary arterial hypertension

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Arquivos
art_MAUAD_Immunopathological_aspects_of_schistosomiasis_associated_pulmonary_arterial_hypertension_2014.PDF (1.88 MB)
Citações na Scopus
31
Tipo de produção
article
Data de publicação
2014
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
W B SAUNDERS CO LTD
Autores
POZZAN, Geanette
LANCAS, Tatiana
OVERBEEK, Maria J.
MELLO, George
Citação
JOURNAL OF INFECTION, v.68, n.1, p.90-98, 2014
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Objectives: Pulmonary hypertension is a lethal complication of chronic hepatosplenic schistosomiasis. Little is known of the underlying (immuno-)histopathological characteristics of lung vasculopathy. Methods: We characterized vasculopathy and inflammation in lung tissue of 10 patients with Schistosomiasis-associated PH (SCH-PH) in comparison to 22 idiopathic pulmonary arterial hypertension (IPAH) patients and 10 normal controls. SCH-PH cases were younger than controls. Results: Plexiform lesions and/or angiomatoid lesions were found in 10/10 SCH-PH, and 19/22 IPAH patients (chi(2) p = 0.22). Lung granulomas with Schistosoma eggs were found in 2/10 of SCH-PH cases. PAH cases had increased peri-arterial density of CD3+ T cells, chymase+ and tryptase+ mast cells when compared to controls (p <= 0.047). SCH-PH showed increased density of CD4+ cells when compared to controls (p = 0.025), paralleled by an increased density of dendritic CD83+ cells when compared to both controls and IPAH patients (p <= 0.022). Conclusion: Both SCH-PH and IPAH feature plexogenic arteriopathy and increased periarterial T cell and mast cell density. SCH-PH and IPAH differ only with respect to the density of dendritic CD83+ cells. These findings imply ongoing antigenic stimulation in SCH-PH, yet a pattern of pulmonary vasculopathy similar to IPAH, suggestive of a final common pathway in their pathogenesis of PAH.
Palavras-chave
Schistosomiasis, Pulmonary hypertension, Histopathology, Inflammation, Plexiform lesions, Dendritic cell, Idiopathic pulmonary arterial hypertension
URI
https://observatorio.fm.usp.br/handle/OPI/5446
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - FM/MCP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/05
Artigos e Materiais de Revistas Científicas - LIM/09
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