Distinct Immunological Profiles Help in the Maintenance of Salivary Secretory IgA Production in Mild Symptoms COVID-19 Patients

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSANTOS, Juliana de Melo Batista dos
dc.contributor.authorAMARAL, Jonatas Bussador do
dc.contributor.authorFRANCA, Carolina Nunes
dc.contributor.authorMONTEIRO, Fernanda Rodrigues
dc.contributor.authorALVARES-SARAIVA, Anuska Marcelino
dc.contributor.authorKALIL, Sandra
dc.contributor.authorDURIGON, Edison Luiz
dc.contributor.authorOLIVEIRA, Danielle Bruna Leal
dc.contributor.authorRODRIGUES, Silvia Sanches
dc.contributor.authorHELLER, Debora
dc.contributor.authorWELTER, Eliane Aparecida Rosseto
dc.contributor.authorPINHO, Joao Renato Rebello
dc.contributor.authorVIEIRA, Rodolfo P.
dc.contributor.authorBACHI, Andre Luis Lacerda
dc.date.accessioned2022-08-12T17:18:35Z
dc.date.available2022-08-12T17:18:35Z
dc.date.issued2022
dc.description.abstractBackgroundRelevant aspects regarding the SARS-CoV-2 pathogenesis and the systemic immune response to this infection have been reported. However, the mucosal immune response of the upper airways two months after SARS-CoV-2 infection in patients with mild/moderate symptoms is still not completely described. Therefore, we investigated the immune/inflammatory responses of the mucosa of the upper airways of mild/moderate symptom COVID-19 patients two months after the SARS-CoV-2 infection in comparison to a control group composed of non-COVID-19 healthy individuals. MethodsA cohort of 80 volunteers (age 37.2 +/- 8.2), including non-COVID-19 healthy individuals (n=24) and COVID-19 patients (n=56) who presented mild/moderate symptoms during a COVID-19 outbreak in Brazil in November and December of 2020. Saliva samples were obtained two months after the COVID-19 diagnosis to assess the levels of SIgA by ELISA and the cytokines by multiplex analysis. ResultsSalivary levels of SIgA were detected in 39 volunteers into the COVID-19 group and, unexpectedly, in 14 volunteers in the control group. Based on this observation, we distributed the volunteers of the control group into without SIgA or with SIgA sub-groups, and COVID-19 group into without SIgA or with SIgA sub-groups. Individuals with SIgA showed higher levels of IL-10, IL-17A, IFN-gamma, IL-12p70, IL-13, and IFN-alpha than those without SIgA. In intergroup analysis, the COVID-19 groups showed higher salivary levels of IL-10, IL-13, IL-17A, and IFN-alpha than the control group. No statistical differences were verified in the salivary levels of IL-6 and IFN-beta. Lower IL-12p70/IL-10 and IFN-gamma/IL-10 ratios were found in the control group without SIgA than the control group with SIgA and the COVID-19 group with SIgA. ConclusionWe were able to present, for the first time, that associations between distinct immunological profiles can help the mucosal immunity to maintain the salivary levels of SIgA in COVID-19 patients two months after the SARS-CoV-2 infection.eng
dc.description.indexMEDLINEeng
dc.identifier.citationFRONTIERS IN IMMUNOLOGY, v.13, article ID 890887, 13p, 2022
dc.identifier.doi10.3389/fimmu.2022.890887
dc.identifier.issn1664-3224
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/48737
dc.language.isoeng
dc.publisherFRONTIERS MEDIA SAeng
dc.relation.ispartofFrontiers in Immunology
dc.rightsopenAccesseng
dc.rights.holderCopyright FRONTIERS MEDIA SAeng
dc.subjectmucosal immunityeng
dc.subjectsalivaeng
dc.subjectcytokineseng
dc.subjectinterferoneng
dc.subjectinterleukineng
dc.subjectSARS-CoV-2eng
dc.subject.otherinnate lymphoid-cellseng
dc.subject.othervirus-infectioneng
dc.subject.othercytokine responseseng
dc.subject.otherimmunoglobulin-aeng
dc.subject.otheroxidative stresseng
dc.subject.otherifn-gammaeng
dc.subject.otherinterleukin-12eng
dc.subject.otherinterferoneng
dc.subject.otherprogressioneng
dc.subject.otherimmunityeng
dc.subject.wosImmunologyeng
dc.titleDistinct Immunological Profiles Help in the Maintenance of Salivary Secretory IgA Production in Mild Symptoms COVID-19 Patientseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalSANTOS, Juliana de Melo Batista dos:Fed Univ Sao Paulo UNIFESP, Postgrad Program Sci Human & Rehabil, Santos, Brazil
hcfmusp.author.externalAMARAL, Jonatas Bussador do:Fed Univ Sao Paulo UNIFESP, Dept Otorhinolaryngol Head & Neck Surg, ENT Res Lab, Sao Paulo, Brazil
hcfmusp.author.externalFRANCA, Carolina Nunes:Santo Amaro Univ UNISA, Postgrad Program Hlth Sci, Sao Paulo, Brazil
hcfmusp.author.externalMONTEIRO, Fernanda Rodrigues:Santo Amaro Univ UNISA, Postgrad Program Hlth Sci, Sao Paulo, Brazil
hcfmusp.author.externalALVARES-SARAIVA, Anuska Marcelino:Univ Paulista Unip, Programa Pos Grad Patol Ambiental & Expt, Sao Paulo, Brazil
hcfmusp.author.externalKALIL, Sandra:Univ Paulista Unip, Programa Pos Grad Patol Ambiental & Expt, Sao Paulo, Brazil
hcfmusp.author.externalDURIGON, Edison Luiz:Univ Sao Paulo, Dept Microbiol, Lab Clin & Mol Virol, Inst Biomed Sci, Sao Paulo, Brazil; Univ Sao Paulo, Sci Platform Pasteur, Sao Paulo, Brazil
hcfmusp.author.externalOLIVEIRA, Danielle Bruna Leal:Univ Sao Paulo, Dept Microbiol, Lab Clin & Mol Virol, Inst Biomed Sci, Sao Paulo, Brazil; Hosp Israelita Albert Einstein, Albert Einstein Inst Teaching & Res IIEP, Sao Paulo, Brazil
hcfmusp.author.externalRODRIGUES, Silvia Sanches:Hosp Israelita Albert Einstein, Albert Einstein Inst Teaching & Res IIEP, Sao Paulo, Brazil
hcfmusp.author.externalHELLER, Debora:Hosp Israelita Albert Einstein, Albert Einstein Inst Teaching & Res IIEP, Sao Paulo, Brazil; Univ Cruzeiro, Post Grad Program Dent, Sao Paulo, Brazil; Univ Texas Hlth Sci Ctr San Antonio, Sch Dent, Dept Periodontol, San Antonio, TX USA
hcfmusp.author.externalWELTER, Eliane Aparecida Rosseto:Hosp Israelita Albert Einstein, Albert Einstein Inst Teaching & Res IIEP, Sao Paulo, Brazil
hcfmusp.author.externalVIEIRA, Rodolfo P.:Fed Univ Sao Paulo UNIFESP, Postgrad Program Sci Human & Rehabil, Santos, Brazil; Unievangelica, Postgrad Program Human Movement & Rehabil, Anapolis, Brazil; Univ Brasil, Postgrad Program Bioengn, Sao Paulo, Brazil
hcfmusp.author.externalBACHI, Andre Luis Lacerda:Fed Univ Sao Paulo UNIFESP, Dept Otorhinolaryngol Head & Neck Surg, ENT Res Lab, Sao Paulo, Brazil; Santo Amaro Univ UNISA, Postgrad Program Hlth Sci, Sao Paulo, Brazil
hcfmusp.citation.scopus1
hcfmusp.contributor.author-fmusphcJOAO RENATO REBELLO PINHO
hcfmusp.description.articlenumber890887
hcfmusp.description.volume13
hcfmusp.origemWOS
hcfmusp.origem.pubmed35686128
hcfmusp.origem.scopus2-s2.0-85131865015
hcfmusp.origem.wosWOS:000807441100001
hcfmusp.publisher.cityLAUSANNEeng
hcfmusp.publisher.countrySWITZERLANDeng
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Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - COVID-19
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