Survival and prognosis of young adults with gastric cancer

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCORMEDI, Marina Candido Visontai
dc.contributor.authorKATAYAMA, Maria Lucia Hirata
dc.contributor.authorGUINDALINI, Rodrigo Santa Cruz
dc.contributor.authorFARAJ, Sheila Friedrich
dc.contributor.authorFOLGUEIRA, Maria Aparecida Azevedo Koike
dc.date.accessioned2018-11-21T17:00:49Z
dc.date.available2018-11-21T17:00:49Z
dc.date.issued2018
dc.description.abstractOBJECTIVES: Survival data for young adults (YA) with gastric cancer is conflicting and scarce in Brazil. The aim of this study was to compare the clinicopathological factors and survival rates of younger and older patients with gastric cancer. METHODS: Hospital registries for 294 gastric cancer patients from a reference cancer hospital in Sao Paulo, Brazil, were consulted for the retrieval of clinicopathological information and follow-up time. Patients were placed into the following groups: YA ( <= 40 years; N.71), older adult (OA: 41 to 65 years; N=129) and elderly (E: >= 66 years; N=94). Differences were assessed through Pearson's chi(2) test, Kaplan-Meier analysis, Log rank test and Cox regression. RESULTS: More YA were diagnosed with advanced disease (clinical stage III/IV: 86.7% YA, 69.9% OA, and 67% E); however, fewer E patients underwent surgery (64.3% YA, 72.7% OA, and 52.4% E). The median overall survival among all patients was 16 months, and the overall survival rate was not significantly different among the age groups (p=0.129). There were no significant differences in the disease-free survival rate. Metastatic disease at diagnosis (HR=4.84; p <0.01) was associated with an increased hazard of death for YA. CONCLUSION: Overall survival was similar among age groups. Metastatic disease at diagnosis was the only factor associated with a poorer prognosis in YA. These results suggest that younger patients deserve special attention regarding the detection of early stage disease.
dc.description.indexMEDLINE
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico - CNPq [149739/2015-0, 307651/2014-2]
dc.identifier.citationCLINICS, v.73, suppl.1, article ID UNSP e651s, 7p, 2018
dc.identifier.doi10.6061/clinics/2018/e651s
dc.identifier.eissn1980-5322
dc.identifier.issn1807-5932
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/29422
dc.language.isoeng
dc.publisherHOSPITAL CLINICAS, UNIV SAO PAULO
dc.relation.ispartofClinics
dc.rightsopenAccess
dc.rights.holderCopyright HOSPITAL CLINICAS, UNIV SAO PAULO
dc.subjectStomach Neoplasms
dc.subjectSurvival
dc.subjectYoung Adult
dc.subject.otherclinicopathological characteristics
dc.subject.otherreproductive factors
dc.subject.otherage
dc.subject.othermortality
dc.subject.othertrends
dc.subject.otherbrazil
dc.subject.otherrisk
dc.subject.otheradenocarcinoma
dc.subject.otherfeatures
dc.subject.wosMedicine, General & Internal
dc.titleSurvival and prognosis of young adults with gastric cancer
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.citation.scopus22
hcfmusp.contributor.author-fmusphcMARINA CANDIDO VISONTAI CORMEDI
hcfmusp.contributor.author-fmusphcMARIA LUCIA HIRATA KATAYAMA
hcfmusp.contributor.author-fmusphcRODRIGO SANTA CRUZ GUINDALINI
hcfmusp.contributor.author-fmusphcSHEILA FRIEDRICH FARAJ
hcfmusp.contributor.author-fmusphcMARIA APARECIDA AZEVEDO KOIKE FOLGUEIRA
hcfmusp.description.articlenumberUNSP e651s
hcfmusp.description.issuesuppl 1
hcfmusp.description.volume73
hcfmusp.origemWOS
hcfmusp.origem.pubmed30281703
hcfmusp.origem.scieloSCIELO:S1807-59322018000200202
hcfmusp.origem.scopus2-s2.0-85054453136
hcfmusp.origem.wosWOS:000684065500003
hcfmusp.publisher.citySAO PAULO
hcfmusp.publisher.countryBRAZIL
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