A Novel Method of Evaluating Ureteropelvic Junction Obstruction: Dynamic Near Infrared Fluorescence Imaging Compared to Standard Modalities to Assess Urinary Obstruction in a Swine Model

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorROWE, Courtney K.
dc.contributor.authorFRANCO, Felipe B.
dc.contributor.authorBARBOSA, Joao A. B. A.
dc.contributor.authorMINNILLO, Brian J.
dc.contributor.authorCHOW, Jeanne S.
dc.contributor.authorTREVES, Ted
dc.contributor.authorRETIK, Alan B.
dc.contributor.authorNGUYEN, Hiep T.
dc.date.accessioned2013-07-30T15:32:34Z
dc.date.available2013-07-30T15:32:34Z
dc.date.issued2012
dc.description.abstractPurpose: Dynamic near infrared fluorescence imaging of the urinary tract provides a promising way to diagnose ureteropelvic junction obstruction. Initial studies demonstrated the ability to visualize urine flow and peristalsis in great detail. We analyzed the efficacy of near infrared imaging in evaluating ureteropelvic junction obstruction, renal involvement and the anatomical detail provided compared to conventional imaging modalities. Materials and Methods: Ten swine underwent partial or complete unilateral ureteral obstruction. Groups were survived for the short or the long term. Imaging was performed with mercaptoacetyltriglycine diuretic renogram, magnetic resonance urogram, excretory urogram, ultrasound and near infrared imaging. Scoring systems for ureteropelvic junction obstruction were developed for magnetic resonance urogram and near infrared imaging. Physicians and medical students graded ureteropelvic junction obstruction based on magnetic resonance urogram and near infrared imaging results. Results: Markers of vascular and urinary dynamics were quantitatively consistent among control renal units. The same markers were abnormal in obstructed renal units with significantly different times of renal phase peak, start of pelvic phase and start of renal uptake. Such parameters were consistent with those obtained with mercaptoacetyltriglycine diuretic renography. Near infrared imaging provided live imaging of urinary flow, which was helpful in identifying the area of obstruction for surgical planning. Physicians and medical students categorized the degree of obstruction appropriately for fluorescence imaging and magnetic resonance urogram. Conclusions: Near infrared imaging offers a feasible way to obtain live, dynamic images of urine flow and ureteral peristalsis. Qualitative and quantitative parameters were comparable to those of conventional imaging. Findings support fluorescence imaging as an accurate, easy to use method of diagnosing ureteropelvic junction obstruction.
dc.description.indexMEDLINE
dc.identifier.citationJOURNAL OF UROLOGY, v.188, n.5, p.1978-1985, 2012
dc.identifier.doi10.1016/j.juro.2012.07.002
dc.identifier.issn0022-5347
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/1202
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofJournal of Urology
dc.rightsrestrictedAccess
dc.rights.holderCopyright ELSEVIER SCIENCE INC
dc.subjectureter
dc.subjectkidney
dc.subjectobstruction
dc.subjectfluorescence
dc.subjectdiagnostic imaging
dc.subject.otherenhanced mr urography
dc.subject.otherpediatric hydronephrosis
dc.subject.otherfunctional assessment
dc.subject.otherchildren
dc.subject.wosUrology & Nephrology
dc.titleA Novel Method of Evaluating Ureteropelvic Junction Obstruction: Dynamic Near Infrared Fluorescence Imaging Compared to Standard Modalities to Assess Urinary Obstruction in a Swine Model
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalROWE, Courtney K.:Childrens Hosp, Dept Urol, Robot Surg Res & Training Ctr, Boston, MA 02115 USA
hcfmusp.author.externalMINNILLO, Brian J.:Childrens Hosp, Dept Urol, Robot Surg Res & Training Ctr, Boston, MA 02115 USA
hcfmusp.author.externalCHOW, Jeanne S.:Childrens Hosp, Dept Radiol, Boston, MA 02115 USA
hcfmusp.author.externalTREVES, Ted:Childrens Hosp, Div Nucl Med, Boston, MA 02115 USA
hcfmusp.author.externalRETIK, Alan B.:Childrens Hosp, Dept Urol, Robot Surg Res & Training Ctr, Boston, MA 02115 USA
hcfmusp.author.externalNGUYEN, Hiep T.:Childrens Hosp, Dept Urol, Robot Surg Res & Training Ctr, Boston, MA 02115 USA
hcfmusp.citation.scopus10
hcfmusp.contributor.author-fmusphcFELIPE BOSCHINI FRANCO
hcfmusp.contributor.author-fmusphcJOAO ARTHUR BRUNHARA ALVES BARBOSA
hcfmusp.description.beginpage1978
hcfmusp.description.endpage1985
hcfmusp.description.issue5
hcfmusp.description.volume188
hcfmusp.origemWOS
hcfmusp.origem.pubmed22999537
hcfmusp.origem.scopus2-s2.0-84867403699
hcfmusp.origem.wosWOS:000310438600103
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
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hcfmusp.scopus.lastupdate2024-04-12
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relation.isAuthorOfPublication.latestForDiscovery8a222124-b2db-48f7-a7ee-a1b9788018c5
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