Chronic mucocutaneous candidiasis associated with paracoccidioidomycosis in a patient with mannose receptor deficiency: First case reported in the literature

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art_VASCONCELOS_Chronic_mucocutaneous_candidiasis_associated_with_paracoccidioidomycosis_in_a_2021.PDF (1001.67 KB)
Citações na Scopus
2
Tipo de produção
article
Data de publicação
2021
DOI
SciELO
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SOC BRASILEIRA MEDICINA TROPICAL
Autores
Citação
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, v.54, article ID e0008-2021, 4p, 2021
Projetos de Pesquisa
Unidades Organizacionais
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Resumo
We describe the first report of a patient with chronic mucocutaneous candidiasis associated with disseminated and recurrent paracoccidioidomycosis. The investigation demonstrated that the patient had a mannose receptor deficiency, which would explain the patient's susceptibility to chronic infection by Candida spp. and systemic infection by paracoccidioidomycosis. Mannose receptors are responsible for an important link between macrophages and fungal cells during phagocytosis. Deficiency of this receptor could explain the susceptibility to both fungal species, suggesting the impediment of the phagocytosis of these fungi in our patient.
Palavras-chave
Chronic mucocutaneous candidiasis, Paracoccidioidomycosis, Mannose receptor deficiency
URI
https://observatorio.fm.usp.br/handle/OPI/40073
Referências
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Coleções
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/31
Artigos e Materiais de Revistas Científicas - LIM/56