GLUT1 Expression in Adult Hepatic Vascular Neoplasms

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorGILL, R.
dc.contributor.authorSEMPOUX, C.
dc.contributor.authorMAKHLOUF, H.
dc.contributor.authorTHUNG, S.
dc.contributor.authorAMANCIO, T. T.
dc.contributor.authorALVES, V.
dc.contributor.authorFERRELL, L.
dc.date.accessioned2013-10-11T21:25:48Z
dc.date.available2013-10-11T21:25:48Z
dc.date.issued2013
dc.description.abstractBackground: GLUT-1 is a glucose transport protein expressed in several vascular lesions, notably in cutaneous juvenile hemangioma (CJH) and hepatic infantile hemangioma (HIH), leading some to suggest that HIH is the visceral counterpart to CJH. GLUT-1 expression has recently been demonstrated in malignant vascular neoplasms involving soft tissue, suggesting that expression may not be restricted to benign vascular tumors. This study aims to further characterize a spectrum of adult hepatic vascular neoplasms for GLUT-1 expression. Design: We used immunohistochemistry in formalin fixed paraffin embedded tissue to evaluate benign vascular liver tumors (cavernous hemangiomas (CH), n=10) as well as malignant vascular liver tumors (epithelioid hemangioendotheliomas (EHE), n=8, and angiosarcomas (AS), n=4)) and the recently described small vessel hepatic hemangioma (SVH) (n=5), which is of uncertain malignant potential. Results: GLUT1 was variably expressed in 38% of hepatic EHE (3/8) and 50% of hepatic angiosarcoma cases (2/4), but in none of the cavernous hemangioma (0/10) or SVH cases (0/5). Conclusions: GLUT1 expression is common in malignant vascular tumors of the liver and should be interpreted with caution as a diagnostic marker of HIH. SVH often has an infiltrative border and may histologically mimic well-differentiated angiosarcoma and therefore, while absence of GLUT-1 staining does not exclude angiosarcoma, positive GLUT-1 staining should raise further suspicion for angiosarcoma in such cases.
dc.description.conferencedateMAR 02-08, 2013
dc.description.conferencelocalBaltimore - MD, EUA
dc.description.conferencename102nd Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology (USCAP)
dc.description.indexMEDLINE
dc.identifier.citationMODERN PATHOLOGY, v.26, suppl.2, p.402A-402A, 2013
dc.identifier.issn0893-3952
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/3038
dc.language.isoeng
dc.publisherNATURE PUBLISHING GROUP
dc.relation.ispartofModern Pathology
dc.rightsrestrictedAccess
dc.rights.holderCopyright NATURE PUBLISHING GROUP
dc.subject.wosPathology
dc.titleGLUT1 Expression in Adult Hepatic Vascular Neoplasms
dc.typeconferenceObject
dc.type.categorymeeting abstract
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.contributor.author-fmusphcTHIAGO TROLEZ AMANCIO
hcfmusp.contributor.author-fmusphcVENANCIO AVANCINI FERREIRA ALVES
hcfmusp.description.beginpage402A
hcfmusp.description.endpage402A
hcfmusp.description.issuesuppl 2
hcfmusp.description.volume26
hcfmusp.origemWOS
hcfmusp.origem.wosWOS:000314444402304
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
relation.isAuthorOfPublication670ce16e-5969-46c8-a567-78431ac9f4df
relation.isAuthorOfPublicationdd94c553-33a7-4e49-9541-3c998006d016
relation.isAuthorOfPublication.latestForDiscovery670ce16e-5969-46c8-a567-78431ac9f4df
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