Nail Apparatus Melanoma: Experience of 10 Years in a Single Institution

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art_LEE_Nail_Apparatus_Melanoma_Experience_of_10_Years_in_2019.PDF (942.94 KB)
Citações na Scopus
16
Tipo de produção
article
Data de publicação
2019
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
KARGER
Autores
Citação
SKIN APPENDAGE DISORDERS, v.5, n.1, p.20-26, 2019
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: Nail apparatus melanoma (NAM) is rare. The higher mortality reported in the literature is most likely due to advanced disease associated with delayed diagnosis and treatment. Objective: All patients diagnosed with NAM were followed at a single reference center during a period of 10 years, with emphasis on dermatological and histological findings. Clinical outcomes were included. Methods: A retrospective review of medical records, photographs, and histopathological examination. Results: 73.7% of the patients were female and their mean age was 47 years. Caucasian and African-American patients had a similar incidence (47.4%). There was only 1 Asian patient in this study (5.3%). All patients presented with nail plate pigmentation. The mean prediagnosis duration was 33 months. A total of 63.2% patients had in situ melanoma and an average Breslow index of 2.18 mm in invasive cases. Fifteen patients underwent conservative surgery and 3 underwent phalanx amputation. All patients survived, and 4 have had more than a 5-year follow-up. Conclusion: In situ lesions showed longitudinal bands or total melanonychia with no nail dystrophy. Invasive cases presented with dystrophic lesions (longitudinal splitting of the nail). Conservative surgery provides a good option without worsening the prognosis. All dermatologists should be aware of early signs of NAM, since prognosis depends on early treatment.
Palavras-chave
Nail apparatus melanoma, Melanonychia, Ungual melanoma, Hutchinson's sign, Nail melanoma epidemiology
URI
https://observatorio.fm.usp.br/handle/OPI/29898
Referências
  1. Amin B, 2008, AM J SURG PATHOL, V32A, P835, DOI 10.1097/PAS.0b013e31815c8578
  2. Banfield CC, 1998, BRIT J DERMATOL, V139, P276
  3. Banfield CC, 1999, BRIT J DERMATOL, V141, P628
  4. Baran R, 1996, J AM ACAD DERMATOL, V34, P87, DOI 10.1016/S0190-9622(96)90839-7
  5. Baran R, 1994, DIS NAIL THEIR MANAG, P483
  6. Bertanha F, 2016, AN BRAS DERMATOL, V91, P318, DOI 10.1590/abd1806-4841.20164495
  7. BLESSING K, 1991, HISTOPATHOLOGY, V19, P425, DOI 10.1111/j.1365-2559.1991.tb00232.x
  8. Boyer A, 1834, GAZ MED PARIS, P212
  9. Bradford PT, 2009, ARCH DERMATOL, V145, P427, DOI 10.1001/archdermatol.2008.609
  10. Chang John Wen-Cheng, 2010, Chang Gung Med J, V33, P602
  11. Cochran AM, 2014, PLAST RECONSTR SURG, V134, P259, DOI 10.1097/PRS.0000000000000529
  12. Cohen T, 2008, AM J SURG, V195, P244, DOI 10.1016/j.amjsurg.2007.03.010
  13. Eberhard P, 1992, HAUTARZT, V43, P286
  14. Edge SB, 2010, ANN SURG ONCOL, V17, P1471, DOI 10.1245/s10434-010-0985-4
  15. Fernandez-Flores A, 2017, ANN DIAGN PATHOL, V26, P64, DOI 10.1016/j.anndiagpath.2016.08.005
  16. Goettmann-Bonvallot S, 1999, J AM ACAD DERMATOL, V41, P17, DOI 10.1016/S0190-9622(99)70399-3
  17. HANEKE E, 1978, HAUTARZT, V29, P389
  18. Haneke E, 2012, DERMATOL THER, V25, P510, DOI 10.1111/j.1529-8019.2012.01515.x
  19. HEATON KM, 1994, ANN SURG, V219, P197, DOI 10.1097/00000658-199402000-00012
  20. High WA, 2004, ARCH DERMATOL, V140, P1102, DOI 10.1001/archderm.140.9.1102
  21. Hutchinson J, 1886, BRIT MED J, V1, P491
  22. Izumi M, 2008, J DERMATOL, V35, P695, DOI 10.1111/j.1346-8138.2008.00551.x
  23. Kato T, 1996, BRIT J DERMATOL, V134, P383, DOI 10.1046/j.1365-2133.1996.19754.x
  24. Kuchelmeister C, 2000, BRIT J DERMATOL, V143, P275, DOI 10.1046/j.1365-2133.2000.03651.x
  25. Lee WJ, 2015, J AM ACAD DERMATOL, V73, P213, DOI 10.1016/j.jaad.2015.04.044
  26. Levit EK, 2000, J AM ACAD DERMATOL, V42, P269, DOI 10.1016/S0190-9622(00)90137-3
  27. Minagawa A, 2017, BRIT J DERMATOL, V177, pE65, DOI 10.1111/bjd.15318
  28. Neczyporenko F, 2014, J EUR ACAD DERMATOL, V28, P550, DOI 10.1111/jdv.12131
  29. PANIZZON R, 1980, HAUTARZT, V31, P132
  30. PATTERSON RH, 1980, CANCER-AM CANCER SOC, V46, P2074, DOI 10.1002/1097-0142(19801101)46:9<2074::AID-CNCR2820460928>3.0.CO;2-K
  31. Phan A, 2006, BRIT J DERMATOL, V155, P561, DOI 10.1111/j.1365-2133.2006.07368.x
  32. Rangwala Sophia, 2011, Dermatol Online J, V17, P8
  33. RIGBY HS, 1992, BRIT J PLAST SURG, V45, P275, DOI 10.1016/0007-1226(92)90051-X
  34. Roh MR, 2010, YONSEI MED J, V51, P562, DOI 10.3349/ymj.2010.51.4.562
  35. Ruben BS, 2010, SEMIN CUTAN MED SURG, V29, P148, DOI 10.1016/j.sder.2010.06.008
  36. SAIDA T, 1992, BRIT J DERMATOL, V126, P529, DOI 10.1111/j.1365-2133.1992.tb11836.x
  37. SEIJI M, 1983, J INVEST DERMATOL, V80, pS56, DOI 10.1038/jid.1983.15
  38. SHAW JHF, 1988, BRIT J SURG, V75, P69, DOI 10.1002/bjs.1800750125
  39. Sureda N, 2011, BRIT J DERMATOL, V165, P852, DOI 10.1111/j.1365-2133.2011.10477.x
  40. Tan KB, 2007, AM J SURG PATHOL, V31, P1902, DOI 10.1097/PAS.0b013e318073c600
  41. Thai K E, 2001, Australas J Dermatol, V42, P71
  42. Tosti A, 2012, PEDIATR DERMATOL, V29, P79, DOI 10.1111/j.1525-1470.2011.01481.x

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Artigos e Materiais de Revistas Científicas - FM/MDT
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