Human papillomavirus and chlamydia trachomatis infections in rheumatoid arthritis under anti-TNF therapy: an observational study

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art_WAISBERG_Human_papillomavirus_and_chlamydia_trachomatis_infections_in_rheumatoid_2015.PDF (174.4 KB)
Citações na Scopus
9
Tipo de produção
article
Data de publicação
2015
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER HEIDELBERG
Autores
BELDI, Mariana C.
Citação
RHEUMATOLOGY INTERNATIONAL, v.35, n.3, p.459-463, 2015
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The objective of this study was to evaluate human papillomavirus (HPV) and Chlamydia trachomatis (CT) infections in RA patients pre- and post-TNF blocker. Fifty female RA patients (ACR criteria), who were eligible to anti-TNF therapy [n = 50 at baseline (BL) and n = 45 after 6 months of treatment (6 M)], and 50 age-matched healthy controls were prospectively enrolled. They were assessed for demographic data, gynecologic, sexual, cervical cytology and histological evaluations, disease parameters and current treatment. HPV DNA and CT DNA testing in cervical specimens were done using Hybrid Capture II assays. At BL, the median current age of RA patients and controls was 49 (18-74) versus 49 (18-74) years, p = 1.0. A trend of lower frequency of HPV infection was observed in AR patients pre-anti-TNF compared with controls (14 vs. 30 %, p = 0.054). Further evaluation of AR patients with and without HPV infection before anti-TNF therapy showed that the former group had higher frequency of sexual intercourses (100 vs. 48 %, p = 0.014), higher median number of sexual partners [1 (1-1) vs. 0 (0-1), p = 0.032] and higher frequency of abnormal cervical cytology (43 vs. 7 %, p = 0.029). Current age, disease duration, disease parameters and treatments were alike in both groups (p > 0.05). At 6 M after TNF blockage, HPV infection remained unchanged in five patients, whereas two became negative and one additional patient turned out to be positive (p = 1.0). CT infection was uniformly negative in RA patients pre- and post-TNF blockage and in controls. Anti-TNF does not seem to increase short-term risk of exacerbation and/or progression of HPV and CT infections in RA patients.
Palavras-chave
HPV infection, Chlamydia trachomatis, Rheumatoid arthritis, TNF blockers
URI
https://observatorio.fm.usp.br/handle/OPI/9284
Referências
  1. Antoniou C, 2008, DERMATOLOGY, V216, P364, DOI 10.1159/000117709
  2. Araujo Daniel Brito, 2010, Acta Reumatol Port, V35, P16
  3. Arnett FC, 1998, ARTHRITIS RHEUM, V31, P315
  4. Beldi MC, 2012, ACTA CYTOL, V56, P160, DOI 10.1159/000335145
  5. Cirpan T, 2007, EUR J GYNAECOL ONCOL, V28, P302
  6. Falcao DD, 2003, J RHEUMATOL, V30, P379
  7. Febronio MV, 2007, LUPUS, V16, P430, DOI 10.1177/0961203307079298
  8. Georgala S, 2012, Dermatol Online J, V18, P9
  9. Hwang Loris, 2004, Adv Pediatr, V51, P379
  10. Ikenberg H, 2014, CURR PROBL DERMATOL, V45, P166, DOI 10.1159/000356515
  11. Kim SY, 2010, NAT REV RHEUMATOL, V6, P165, DOI 10.1038/nrrheum.2009.279
  12. Lyrio LDC, 2013, RHEUMATOL INT, V33, P335, DOI 10.1007/s00296-012-2426-0
  13. Nonnenmacher B, 2002, REV SAUDE PUBL, V36, P95, DOI 10.1590/S0034-89102002000100015
  14. PREVOO MLL, 1995, ARTHRITIS RHEUM, V38, P44, DOI 10.1002/art.1780380107
  15. Rojo-Contreras W, 2012, LUPUS, V21, P365, DOI 10.1177/0961203311425517
  16. Santana IU, 2011, CLIN RHEUMATOL, V30, P665, DOI 10.1007/s10067-010-1606-0
  17. Solomon D, 2002, JAMA-J AM MED ASSOC, V287, P2114, DOI 10.1001/jama.287.16.2114
  18. VANDERHEIJDE DMFM, 1990, ANN RHEUM DIS, V49, P916, DOI 10.1136/ard.49.11.916

Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - FM/MPE
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/ICr
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/03
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