Myocardial AT1 gene expression is increased in a model of left ventricular hypertrophy induced by high salt intake
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Tipo de produção
conferenceObject
Data de publicação
2013
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Título do Volume
Editora
FEDERATION AMER SOC EXP BIOL
Citação
FASEB JOURNAL, v.27, 2013
Resumo
Objective: To evaluate gene expression of the renin-angiotensin system components in a model of left ventricular hypertrophy induced by high salt intake demonstrated in a previous study. Methods: Wistar rats were fed normal (NS1.3% NaCl) or high (HS 8%) salt diet since weaning. From the 7th week of age, two HS subgroups received hydralazine or losartan (HZ 15 and LOS 20mg/kg/day). Angiotensinogen, renin, ACE, ACE2, AT1 and AT2 gene expression in left ventricle were measured. Data are reported as mean±SEM. Means in row with superscripts without a common letter differ, P<0.05. Conclusion: High salt intake increases AT1 gene expression, however it is prevented by losartan treatment.