Indigenous people from Amazon show genetic signatures of pathogen-driven selection

Página do item simplificado
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCOUTO-SILVA, Caina M.
dc.contributor.authorNUNES, Kelly
dc.contributor.authorVENTURINI, Gabriela
dc.contributor.authorSILVA, Marcos Araujo Castro e
dc.contributor.authorV, Lygia Pereira
dc.contributor.authorCOMAS, David
dc.contributor.authorPEREIRA, Alexandre
dc.contributor.authorHUNEMEIER, Tabita
dc.date.accessioned2023-06-21T14:33:04Z
dc.date.available2023-06-21T14:33:04Z
dc.date.issued2023
dc.description.abstractEcological conditions in the Amazon rainforests are historically favorable for the transmission of numerous tropical diseases, especially vector-borne diseases. The high diversity of pathogens likely contributes to the strong selective pressures for human survival and reproduction in this region. However, the genetic basis of human adaptation to this complex ecosystem remains unclear. This study investigates the possible footprints of genetic adaptation to the Amazon rainforest environment by analyzing the genomic data of 19 native populations. The results based on genomic and functional analysis showed an intense signal of natural selection in a set of genes related to Trypanosoma cruzi infection, which is the pathogen responsible for Chagas disease, a neglected tropical parasitic disease native to the Americas that is currently spreading worldwide.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP) [17/14916-8, 15/26875-9, 19/11821-1]
dc.description.sponsorshipNHLBI [R01HL133165]
dc.description.sponsorshipNIH [R01 GM075091, 5U19AI098461]
dc.identifier.citationSCIENCE ADVANCES, v.9, n.10, 2023
dc.identifier.issn2375-2548
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/54331
dc.language.isoeng
dc.publisherAMER ASSOC ADVANCEMENT SCIENCEeng
dc.relation.ispartofScience Advances
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright AMER ASSOC ADVANCEMENT SCIENCEeng
dc.subject.othergenome-wide analysiseng
dc.subject.otherchagas-diseaseeng
dc.subject.otherpositive selectioneng
dc.subject.othernovelty seekingeng
dc.subject.otherr packageeng
dc.subject.otherpopulationeng
dc.subject.othergrancalcineng
dc.subject.otherbehavioreng
dc.subject.otherrevealseng
dc.subject.otheradmixtureeng
dc.subject.wosMultidisciplinary Scienceseng
dc.titleIndigenous people from Amazon show genetic signatures of pathogen-driven selectioneng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryEspanha
hcfmusp.affiliation.countryisoes
hcfmusp.author.externalCOUTO-SILVA, Caina M.:Univ Sao Paulo, Dept Genet & Biol Evolut, Inst Biociencias, BR-05508090 Sao Paulo, SP, Brazil
hcfmusp.author.externalNUNES, Kelly:Univ Sao Paulo, Dept Genet & Biol Evolut, Inst Biociencias, BR-05508090 Sao Paulo, SP, Brazil
hcfmusp.author.externalSILVA, Marcos Araujo Castro e:Univ Sao Paulo, Dept Genet & Biol Evolut, Inst Biociencias, BR-05508090 Sao Paulo, SP, Brazil; Univ Pompeu Fabra, Inst Biol Evolut, Dept Med & Ciencies Vida, Barcelona 08003, Spain
hcfmusp.author.externalV, Lygia Pereira:Univ Sao Paulo, Dept Genet & Biol Evolut, Inst Biociencias, BR-05508090 Sao Paulo, SP, Brazil
hcfmusp.author.externalCOMAS, David:Univ Pompeu Fabra, Inst Biol Evolut, Dept Med & Ciencies Vida, Barcelona 08003, Spain
hcfmusp.author.externalHUNEMEIER, Tabita:Univ Sao Paulo, Dept Genet & Biol Evolut, Inst Biociencias, BR-05508090 Sao Paulo, SP, Brazil; Univ Pompeu Fabra, Inst Biol Evolut, CSIC, Barcelona 08003, Spain
hcfmusp.contributor.author-fmusphcGABRIELA VENTURINI DA SILVA
hcfmusp.contributor.author-fmusphcALEXANDRE DA COSTA PEREIRA
hcfmusp.description.issue10
hcfmusp.description.volume9
hcfmusp.origemWOS
hcfmusp.origem.pubmed36888716
hcfmusp.origem.wosWOS:000959821900020
hcfmusp.publisher.cityWASHINGTONeng
hcfmusp.publisher.countryUSAeng
hcfmusp.relation.referenceAcuna-Alonzo V, 2010, HUM MOL GENET, V19, P2877, DOI 10.1093/hmg/ddq173eng
hcfmusp.relation.referenceAiello Vera Demarchi, 2015, Autops Case Rep, V5, P7, DOI 10.4322/acr.2015.012eng
hcfmusp.relation.referenceAlexander DH, 2009, GENOME RES, V19, P1655, DOI 10.1101/gr.094052.109eng
hcfmusp.relation.referenceALLISON MJ, 1973, AM REV RESPIR DIS, V107, P985eng
hcfmusp.relation.referenceAltshuler DM, 2015, NATURE, V526, P68, DOI 10.1038/nature15393eng
hcfmusp.relation.referenceAmorim CEG, 2017, P NATL ACAD SCI USA, V114, P2195, DOI 10.1073/pnas.1620541114eng
hcfmusp.relation.referenceAmorim CEG, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0121557eng
hcfmusp.relation.referenceAufderheide AC, 2004, P NATL ACAD SCI USA, V101, P2034, DOI 10.1073/pnas.0307312101eng
hcfmusp.relation.referenceBAILEY RC, 1989, AM ANTHROPOL, V91, P59, DOI 10.1525/aa.1989.91.1.02a00040eng
hcfmusp.relation.referenceBergey CM, 2018, P NATL ACAD SCI USA, V115, pE11256, DOI 10.1073/pnas.1812135115eng
hcfmusp.relation.referenceBergstrom A, 2020, SCIENCE, V367, P1339, DOI 10.1126/science.aay5012eng
hcfmusp.relation.referenceBorda V, 2020, P NATL ACAD SCI USA, V117, P32557, DOI 10.1073/pnas.2013773117eng
hcfmusp.relation.referenceBrowning SR, 2015, AM J HUM GENET, V97, P404, DOI 10.1016/j.ajhg.2015.07.012eng
hcfmusp.relation.referenceBuikstra J.E., 1991, HUMAN PALEOPATHOLOGY, P161eng
hcfmusp.relation.referenceBycroft C, 2018, NATURE, V562, P203, DOI 10.1038/s41586-018-0579-zeng
hcfmusp.relation.referenceCasares-Marfil D, 2021, HUM MOL GENET, V30, P2503, DOI 10.1093/hmg/ddab213eng
hcfmusp.relation.referenceSilva MACE, 2022, MOL BIOL EVOL, V39, DOI 10.1093/molbev/msab339eng
hcfmusp.relation.referenceSilva MACE, 2021, P NATL ACAD SCI USA, V118, DOI 10.1073/pnas.2025739118eng
hcfmusp.relation.referenceSilva MACE, 2020, P NATL ACAD SCI USA, V117, P2372, DOI 10.1073/pnas.1909075117eng
hcfmusp.relation.referenceConfalonieri UEC, 2014, ACTA TROP, V129, P33, DOI 10.1016/j.actatropica.2013.09.013eng
hcfmusp.relation.referenceCsillery K, 2012, METHODS ECOL EVOL, V3, P475, DOI 10.1111/j.2041-210X.2011.00179.xeng
hcfmusp.relation.referenceDahlstrom E, 2017, CURR DIABETES REP, V17, DOI 10.1007/s11892-017-0906-zeng
hcfmusp.relation.referencede Arias AR, 2022, MEM I OSWALDO CRUZ, V117, DOI 10.1590/0074-02760210130eng
hcfmusp.relation.referencede Filippo C, 2016, MOL BIOL EVOL, V33, P1435, DOI 10.1093/molbev/msw023eng
hcfmusp.relation.referencede Rubira A, 2016, ADAPT HUM BEHAV PHYS, V2, P77, DOI 10.1007/s40750-015-0033-5eng
hcfmusp.relation.referenceDelaneau O, 2013, NAT METHODS, V10, P5, DOI 10.1038/nmeth.2307eng
hcfmusp.relation.referenceDeng XT, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0079629eng
hcfmusp.relation.referenceEberhard FE, 2020, ELIFE, V9, DOI 10.7554/eLife.52072eng
hcfmusp.relation.referenceEwing G, 2010, BIOINFORMATICS, V26, P2064, DOI 10.1093/bioinformatics/btq322eng
hcfmusp.relation.referenceLima-Costa MF, 2016, PLOS NEGLECT TROP D, V10, DOI 10.1371/journal.pntd.0004724eng
hcfmusp.relation.referenceFeske S, 2003, BIOCHEM BIOPH RES CO, V311, P1117, DOI 10.1016/j.bbrc.2003.09.174eng
hcfmusp.relation.referenceLidani KCF, 2019, FRONT PUBLIC HEALTH, V7, DOI 10.3389/fpubh.2019.00166eng
hcfmusp.relation.referenceGautier M, 2017, MOL ECOL RESOUR, V17, P78, DOI 10.1111/1755-0998.12634eng
hcfmusp.relation.referenceGautier M, 2012, BIOINFORMATICS, V28, P1176, DOI 10.1093/bioinformatics/bts115eng
hcfmusp.relation.referenceGimeno SGA, 2009, J EPIDEMIOL COMMUN H, V63, P299, DOI 10.1136/jech.2008.077966eng
hcfmusp.relation.referenceGriss J, 2020, MOL CELL PROTEOMICS, V19, DOI 10.1074/mcp.TIR120.002155eng
hcfmusp.relation.referenceGrote S., GOFUNCR GEN ONT ENReng
hcfmusp.relation.referenceGuernier V, 2004, PLOS BIOL, V2, P740, DOI 10.1371/journal.pbio.0020141eng
hcfmusp.relation.referenceGuhl F, 1997, LANCET, V349, P1370, DOI 10.1016/S0140-6736(05)63207-2eng
hcfmusp.relation.referenceHarris DN, 2018, P NATL ACAD SCI USA, V115, pE6526, DOI 10.1073/pnas.1720798115eng
hcfmusp.relation.referenceHart T. B., 1996, CASE STUDIES HUMAN E, P55eng
hcfmusp.relation.referenceHudson RR, 2002, BIOINFORMATICS, V18, P337, DOI 10.1093/bioinformatics/18.2.337eng
hcfmusp.relation.referenceHunemeier T, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0038862eng
hcfmusp.relation.referenceIyengar SK, 2015, PLOS GENET, V11, DOI 10.1371/journal.pgen.1005352eng
hcfmusp.relation.referenceJiao H, 2011, BMC MED GENOMICS, V4, DOI 10.1186/1755-8794-4-51eng
hcfmusp.relation.referenceJones AV, 2017, HUM MOL GENET, V26, P1391, DOI 10.1093/hmg/ddx036eng
hcfmusp.relation.referenceKanehisa M, 2000, NUCLEIC ACIDS RES, V28, P27, DOI 10.1093/nar/28.1.27eng
hcfmusp.relation.referenceKennedy RB, 2012, HUM GENET, V131, P1403, DOI 10.1007/s00439-012-1174-2eng
hcfmusp.relation.referenceKim TW, 2016, EUR J IMMUNOL, V46, P712, DOI 10.1002/eji.201545567eng
hcfmusp.relation.referenceKim YR, 2019, GENES GENOM, V41, P983, DOI 10.1007/s13258-019-00840-8eng
hcfmusp.relation.referenceLima VS, 2008, EMERG INFECT DIS, V14, P1001, DOI 10.3201/eid1406.070707eng
hcfmusp.relation.referenceLindo J, 2018, SCI ADV, V4, DOI 10.1126/sciadv.aau4921eng
hcfmusp.relation.referenceLiu FZ, 2004, BIOSCI BIOTECH BIOCH, V68, P894, DOI 10.1271/bbb.68.894eng
hcfmusp.relation.referenceLlamas B, 2016, SCI ADV, V2, DOI 10.1126/sciadv.1501385eng
hcfmusp.relation.referenceMi HY, 2019, NUCLEIC ACIDS RES, V47, pD419, DOI 10.1093/nar/gky1038eng
hcfmusp.relation.referenceMizuguchi T, 2018, HUM MOL GENET, V27, P1421, DOI 10.1093/hmg/ddy052eng
hcfmusp.relation.referenceMonteiro FA, 2018, ADV PARASIT, V99, P265, DOI 10.1016/bs.apar.2017.12.002eng
hcfmusp.relation.referenceO'Brien RJ, 2003, J AM COLL CARDIOL, V42, P719, DOI 10.1016/S0735-1097(03)00755-1eng
hcfmusp.relation.referenceOjeda-Granados C, 2022, MOL BIOL EVOL, V39, DOI 10.1093/molbev/msab290eng
hcfmusp.relation.referenceOrrego PR, 2014, PLOS NEGLECT TROP D, V8, DOI 10.1371/journal.pntd.0002676eng
hcfmusp.relation.referenceOssa H, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0164414eng
hcfmusp.relation.referencePatterson N, 2012, GENETICS, V192, P1065, DOI 10.1534/genetics.112.145037eng
hcfmusp.relation.referencePeneau J, 2016, PLOS NEGLECT TROP D, V10, DOI 10.1371/journal.pntd.0004427eng
hcfmusp.relation.referenceNunes MCP, 2018, CIRCULATION, V138, pE169, DOI 10.1161/CIR.0000000000000599eng
hcfmusp.relation.referenceLourenco AE, 2008, AM J HUM BIOL, V20, P564, DOI 10.1002/ajhb.20781eng
hcfmusp.relation.referenceRamirez MI, 2000, MOL BIOCHEM PARASIT, V111, P235, DOI 10.1016/S0166-6851(00)00309-1eng
hcfmusp.relation.referenceRatnam J, 2011, GLOBAL ECOL BIOGEOGR, V20, P653, DOI 10.1111/j.1466-8238.2010.00634.xeng
hcfmusp.relation.referenceRedolat Rosa, 2009, Curr Drug Abuse Rev, V2, P230eng
hcfmusp.relation.referenceRees JS, 2020, TRENDS GENET, V36, P415, DOI 10.1016/j.tig.2020.03.006eng
hcfmusp.relation.referenceRobichon C, 2006, BBA-MOL CELL BIOL L, V1761, P1107, DOI 10.1016/j.bbalip.2006.07.007eng
hcfmusp.relation.referenceSalzano F. M., 2019, AMERINDIAN MICROCOSMeng
hcfmusp.relation.referenceSantos R. V., 1994, SAUDE POVOS INDIGENAeng
hcfmusp.relation.referenceSarbassov DD, 2005, SCIENCE, V307, P1098, DOI 10.1126/science.1106148eng
hcfmusp.relation.referenceSeim I, 2008, BMC MOL BIOL, V9, DOI 10.1186/1471-2199-9-95eng
hcfmusp.relation.referenceSharma Arun, 2018, Curr Protoc Hum Genet, V96, DOI 10.1002/cphg.53eng
hcfmusp.relation.referenceShelly EM, 2016, PUBLIC HEALTH REP, V131, P59, DOI 10.1177/003335491613100112eng
hcfmusp.relation.referenceSkoglund P, 2015, NATURE, V525, P104, DOI 10.1038/nature14895eng
hcfmusp.relation.referenceSoares LP, 2015, DIABETOL METAB SYNDR, V7, DOI 10.1186/s13098-015-0100-xeng
hcfmusp.relation.referenceSowton AP, 2020, MOL GENET METAB REP, V23, DOI 10.1016/j.ymgmr.2020.100580eng
hcfmusp.relation.referenceTauil PL, 2009, EMERG INFECT DIS, V15, P625, DOI 10.3201/eid1504.090169eng
hcfmusp.relation.referenceTournebize R, 2022, PLOS GENET, V18, DOI 10.1371/journal.pgen.1010243eng
hcfmusp.relation.referenceTovo-Rodrigues L, 2010, AM J PHYS ANTHROPOL, V143, P458, DOI 10.1002/ajpa.21358eng
hcfmusp.relation.referenceWalker RS, 2015, SCI REP-UK, V5, DOI 10.1038/srep14032eng
hcfmusp.relation.referenceWang K, 2010, NUCLEIC ACIDS RES, V38, DOI 10.1093/nar/gkq603eng
hcfmusp.relation.referenceWatanabe K, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01261-5eng
hcfmusp.relation.referenceWei WH, 2012, EUR J HUM GENET, V20, P857, DOI 10.1038/ejhg.2012.17eng
hcfmusp.relation.referenceWingo T, 2016, J NEUROIMMUNE PHARM, V11, P456, DOI 10.1007/s11481-015-9636-7eng
hcfmusp.relation.referenceXu AP, 2018, BIOSCIENCE REP, V38, DOI [10.1042/BSR20181160, 10.1042/bsr20181160]eng
hcfmusp.relation.referenceXu P, 2006, CELL IMMUNOL, V240, P116, DOI 10.1016/j.cellimm.2006.07.004eng
hcfmusp.relation.referenceYi X, 2010, SCIENCE, V329, P75, DOI 10.1126/science.1190371eng
hcfmusp.relation.referenceZhang B, 2005, NUCLEIC ACIDS RES, V33, pW741, DOI 10.1093/nar/gki475eng
relation.isAuthorOfPublication11107a70-e1cc-4e74-9dbc-cae210e58af5
relation.isAuthorOfPublication415ce7ca-65c1-4699-b6f4-19dae8b03849
relation.isAuthorOfPublication.latestForDiscovery11107a70-e1cc-4e74-9dbc-cae210e58af5
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
art_COUTO-SILVA_Indigenous_people_from_Amazon_show_genetic_signatures_of_2023.PDF
Tamanho:
886.99 KB
Formato:
Adobe Portable Document Format
Descrição:
publishedVersion (English)
Baixar
Coleções
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/13