Brain Structure in Obsessive-Compulsive Disorder: The OCD Brain Imaging Consortium (OBIC) Multi-Center Voxel-Based Morphometry Study

Página do item simplificado
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorHEUVEL, Odile A. van den
dc.contributor.authorALONSO, Pino
dc.contributor.authorSCHWEREN, Lizanne J. S.
dc.contributor.authorMATAIX-COLS, David
dc.contributor.authorVELTMAN, Dick J.
dc.contributor.authorMENCHON, Jose M.
dc.contributor.authorLOCHNER, Christine
dc.contributor.authorNAKAMAE, Takashi
dc.contributor.authorKWON, Jun Soo
dc.contributor.authorHOEXTER, Marcelo Q.
dc.contributor.authorFIGEE, Martijn
dc.contributor.authorMAS, Caries Soriano
dc.contributor.authorFOUCHE, Jean-Paul
dc.contributor.authorNISHIDA, Seiji
dc.contributor.authorJUNG, Wi Hoon
dc.contributor.authorSATO, Soao R.
dc.contributor.authorDENYS, Damiaan A. J. P.
dc.contributor.authorSTEIN, Dan J.
dc.contributor.groupauthorOCD Brain Imaging Consortium
dc.date.accessioned2013-10-11T21:33:57Z
dc.date.available2013-10-11T21:33:57Z
dc.date.issued2012
dc.description.abstractBackground: Voxel-based morphometry (VBM) studies in obsessive-compulsive disorder (OCD) have shown altered regional grey (GM) and white matter (WM) volume of frontal-striatal and limbic regions. Recent meta-analyses were usefulto evaluate the consistency across individual VBM studies. However, a mega-analysis of pooled data provides increased statistical power to study more subtle abnormalities or specific demographic and clinical parameters. Methods: By combining resources, the OCD Brain Imaging Consortium (OBIC) enabled a multi-center mega-analysis on 1.5 Tesla T1-weighted MRI scans of 446 OCD patients and 388 controls, using DARTEL VBM (SPM8). Analyses included two-sample T tests for group comparisons (e.g., patients vs. controls, medicated vs. non-medicated patients) and regression analyses to study the effects of age, symptom profiles, and disease severity on regional GM and WM volume. Effects are reported at p<0.05 FWE-corrected. Results: OCD patients have significantly decreased GM volume of the dorsomedial prefrontal, insular and orbitofrontal cortex. Regional WM volume was decreased in the frontal regions and thalamus, areas connecting prefrontal cortex and basal ganglia. A group x age effect was found at lower statistical significance (p<0.001 uncorrected) in the bilateral striatum and insular cortex, suggesting relative preservation of volume in the striatum and relative loss of volume in the insula with increasing age in OCD patients compared with controls. There was no effect of disease severity and medication on regional GM or WM volume. Conclusions: OCD patients show altered GM and WM volume of frontalstriatal and limbic regions, possibly partly related to altered brain development and maturation during life.
dc.description.conferencedateMAY 03-05, 2012
dc.description.conferencelocalPhiladelphia - PA, EUA
dc.description.conferencename67th Annual Scientific Convention and Meeting of the Society-of-Biological-Psychiatry
dc.description.indexMEDLINE
dc.identifier.citationBIOLOGICAL PSYCHIATRY, v.71, n.8, suppl.S, p.179S-180S, 2012
dc.identifier.issn0006-3223
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/3175
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofBiological Psychiatry
dc.rightsrestrictedAccess
dc.rights.holderCopyright ELSEVIER SCIENCE INC
dc.subjectobsessive-compulsive
dc.subjectVoxel-based morphometry
dc.subjectmulti-center
dc.subjectfrontal-striatal
dc.subjectlimbic
dc.subject.wosNeurosciences
dc.subject.wosPsychiatry
dc.titleBrain Structure in Obsessive-Compulsive Disorder: The OCD Brain Imaging Consortium (OBIC) Multi-Center Voxel-Based Morphometry Study
dc.typeconferenceObject
dc.type.categorymeeting abstract
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryInglaterra
hcfmusp.affiliation.countryJapão
hcfmusp.affiliation.countryCoréia do Sul
hcfmusp.affiliation.countryÁfrica do Sul
hcfmusp.affiliation.countryHolanda
hcfmusp.affiliation.countryEspanha
hcfmusp.affiliation.countryisonl
hcfmusp.affiliation.countryisoes
hcfmusp.affiliation.countryisogb
hcfmusp.affiliation.countryisojp
hcfmusp.affiliation.countryisokr
hcfmusp.affiliation.countryisoza
hcfmusp.author.externalHEUVEL, Odile A. van den:Vrije Univ Amsterdam Med Ctr, Amsterdam, Netherlands
hcfmusp.author.externalALONSO, Pino:Univ Barcelona, CIBERSAM, Bellvitge Univ Hosp IDBELL, Barcelona, Spain
hcfmusp.author.externalSCHWEREN, Lizanne J. S.:Vrije Univ Amsterdam Med Ctr, Amsterdam, Netherlands
hcfmusp.author.externalMATAIX-COLS, David:Kings Coll London, Inst Psychiat, London WC2R 2LS, England
hcfmusp.author.externalVELTMAN, Dick J.:Vrije Univ Amsterdam Med Ctr, Amsterdam, Netherlands
hcfmusp.author.externalMENCHON, Jose M.:Univ Barcelona, CIBERSAM, Bellvitge Univ Hosp IDBELL, Barcelona, Spain
hcfmusp.author.externalNAKAMAE, Takashi:Kyoto Prefectural Univ Med, Kyoto, Japan
hcfmusp.author.externalKWON, Jun Soo:Seoul Natl Univ Hosp, Seoul 110744, South Korea
hcfmusp.author.externalMAS, Caries Soriano:Univ Barcelona, CIBERSAM, Bellvitge Univ Hosp IDBELL, Barcelona, Spain
hcfmusp.author.externalFOUCHE, Jean-Paul:Univ Stellenbosch, ZA-7600 Stellenbosch, South Africa
hcfmusp.author.externalNISHIDA, Seiji:Kyoto Prefectural Univ Med, Kyoto, Japan
hcfmusp.author.externalJUNG, Wi Hoon:Seoul Natl Univ Hosp, Seoul 110744, South Korea
hcfmusp.author.externalDENYS, Damiaan A. J. P.:Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands
hcfmusp.author.externalSTEIN, Dan J.:Univ Cape Town, ZA-7925 Cape Town, South Africa
hcfmusp.contributor.author-fmusphcMARCELO QUEIROZ HOEXTER
hcfmusp.contributor.author-fmusphcANA LUIZA CARRARI SAYEGH
hcfmusp.description.beginpage179S
hcfmusp.description.endpage180S
hcfmusp.description.issue8
hcfmusp.description.issuesuppl S
hcfmusp.description.volume71
hcfmusp.origemWOS
hcfmusp.origem.wosWOS:000302466000563
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
relation.isAuthorOfPublicationfb3862ee-3c68-42fa-b08a-2658c28981ee
relation.isAuthorOfPublication31e5de50-f7c9-44bb-bc4f-12cf6151d442
relation.isAuthorOfPublication.latestForDiscoveryfb3862ee-3c68-42fa-b08a-2658c28981ee
Arquivos
Coleções
Comunicações em Eventos - HC/IPq
Comunicações em Eventos - HC/InCor
Comunicações em Eventos - LIM/11
Comunicações em Eventos - LIM/21