Characterization of traumatic spinal cord injury model in relation to neuropathic pain in the rat

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorBATISTA, Chary Marquez
dc.contributor.authorMARIANO, Eric Domingos
dc.contributor.authorONUCHIC, Fernando
dc.contributor.authorDALE, Camila Squarzoni
dc.contributor.authorSANTOS, Gustavo Bispo dos
dc.contributor.authorCRISTANTE, Alexandre Fogaca
dc.contributor.authorOTOCH, Jose Pinhata
dc.contributor.authorTEIXEIR, Manoel Jacobsen
dc.contributor.authorMORGALLA, Matthias
dc.contributor.authorLEPSKI, Guilherme
dc.date.accessioned2019-06-26T17:31:02Z
dc.date.available2019-06-26T17:31:02Z
dc.date.issued2019
dc.description.abstractPurpose/aim: Neuropathic pain following spinal cord injury (SCI) has a tremendous impact on patient's quality of life, and frequently is the most limiting aspect of the disease. In view of the severity of this condition and the absence of effective treatments, the establishment of a reliable animal model that reproduces neuropathic pain after injury is crucial for a better understanding of the pathophysiology and for the development of new therapeutic strategies. Thus, the objective of the present study was to standardize the traumatic SCI model in relation to neuropathic pain.Materials and methods: Wistar rats were submitted to SCI of mild intensity (pendulum height 12.5mm) or moderate intensity (pendulum height 25mm) using the New York University Impactor equipment. Behavioural assessment was performed during 8weeks. Thereafter, spinal cords were processed for immunohistochemistry.Results: The animals of the moderate injury group in comparison with mild injury had a greater motor function deficit, worse mechanical allodynia, and latter bladder recovery; moreover, histological analysis revealed more extensive lesions with lower neuronal population.Conclusions: Our study suggests that moderate SCI causes a progressive and long-lasting painful condition (at least 8weeks), in addition to motor impairment, and thus represents a reliable animal model for the study of chronic neuropathic pain after SCI.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipFAPESP - Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [2013/12056-0, 2015/02154-0]
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [140381/2015-5]
dc.identifier.citationSOMATOSENSORY AND MOTOR RESEARCH, v.36, n.1, p.14-23, 2019
dc.identifier.doi10.1080/08990220.2018.1563537
dc.identifier.eissn1369-1651
dc.identifier.issn0899-0220
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/32504
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTDeng
dc.relation.ispartofSomatosensory and Motor Research
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright TAYLOR & FRANCIS LTDeng
dc.subjectSpinal cord injurieseng
dc.subjectchronic paineng
dc.subjecthyperalgesiaeng
dc.subjectanimal experimentationeng
dc.subjectrats Wistareng
dc.subject.otherquality-of-lifeeng
dc.subject.othermechanical allodyniaeng
dc.subject.otherfunctional recoveryeng
dc.subject.othercompression injuryeng
dc.subject.otherrodent modeleng
dc.subject.otheractivationeng
dc.subject.otherstimulationeng
dc.subject.otherindividualseng
dc.subject.otherdepressioneng
dc.subject.otherspasticityeng
dc.subject.wosNeuroscienceseng
dc.titleCharacterization of traumatic spinal cord injury model in relation to neuropathic pain in the rateng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryAlemanha
hcfmusp.affiliation.countryisode
hcfmusp.author.externalDALE, Camila Squarzoni:Univ Sao Paulo, Inst Biomed Sci, Sao Paulo, Brazil
hcfmusp.author.externalMORGALLA, Matthias:Eberhard Karls Univ Tubingen, Dept Neurosurg, Tubingen, Germany
hcfmusp.contributor.author-fmusphcBATISTA, Chary Marquez
hcfmusp.contributor.author-fmusphcMARIANO, Eric Domingos
hcfmusp.contributor.author-fmusphcONUCHIC, Fernando
hcfmusp.contributor.author-fmusphcSANTOS, Gustavo Bispo dos
hcfmusp.contributor.author-fmusphcCRISTANTE, Alexandre Fogaca
hcfmusp.contributor.author-fmusphcOTOCH, Jose Pinhata
hcfmusp.contributor.author-fmusphcTEIXEIR, Manoel Jacobsen
hcfmusp.contributor.author-fmusphcLEPSKI, Guilherme
hcfmusp.description.beginpage14
hcfmusp.description.endpage23
hcfmusp.description.issue1
hcfmusp.description.volume36
hcfmusp.jcrSOMATOSENS MOT RES
hcfmusp.origemWOS
hcfmusp.origem.pubmed30870070
hcfmusp.origem.wosWOS:000468239800003
hcfmusp.publisher.cityABINGDONeng
hcfmusp.publisher.countryENGLANDeng
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