Concurrent exercise training induces additional benefits to hydrochlorothiazide: Evidence for an improvement of autonomic control and oxidative stress in a model of hypertension and postmenopause
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Citações na Scopus
2
Tipo de produção
article
Data de publicação
2023
Título da Revista
ISSN da Revista
Título do Volume
Editora
PUBLIC LIBRARY SCIENCE
Autores
FERREIRA, Maycon Junior
SILVA, Michel Pablo dos Santos Ferreira
BERNARDES, Nathalia
ANGELIS, Katia De
Citação
PLOS ONE, v.18, n.8, 2023
Resumo
ObjectiveThis study aimed to evaluate whether exercise training could contribute to a better modulation of the neurohumoral mechanisms linked to the pathophysiology of arterial hypertension (AH) in postmenopausal hypertensive rats treated with hydrochlorothiazide (HCTZ). MethodsFemale spontaneously hypertensive rats (SHR) (150-200g, 90 days old) were distributed into 5 hypertensive groups (n = 7-8 rats/group): control (C), ovariectomized (O), ovariectomized treated with HCTZ (OH), ovariectomized submitted to exercise training (OT) and ovariectomized submitted to exercise training and treated with HCTZ (OTH). Ovarian hormone deprivation was performed through bilateral ovariectomy. HCTZ (30mg/kg/day) and concurrent exercise training (3d/wk) were conducted lasted 8 weeks. Arterial pressure (AP) was directly recorded. Cardiac effort was evaluated using the rate-pressure product (RPP = systolic AP x heart rate). Vasopressin V1 receptor antagonist, losartan and hexamethonium were sequentially injected to evaluate the vasopressor systems. Inflammation and oxidative stress were evaluated in cardiac tissue. ResultsIn addition to the reduction in AP, trained groups improved RPP, AP variability, bradycardic (OT: -1.3 & PLUSMN; 0.4 and OTH: -1.6 & PLUSMN; 0.3 vs. O: -0.6 & PLUSMN; 0.3 bpm/mmHg) and tachycardic responses of baroreflex sensitivity (OT: -2.4 & PLUSMN; 0.8 and OTH: -2.4 & PLUSMN; 0.8 vs. O: -1.3 & PLUSMN; 0.5 bpm/mmHg), NADPH oxidase and IL-10/TNF-& alpha; ratio. Hexamethonium injection revealed reduced sympathetic contribution on basal AP in OTH group (OTH: -49.8 & PLUSMN; 12.4 vs. O: -74.6 & PLUSMN; 18.1 mmHg). Furthermore, cardiac sympathovagal balance (LF/HF ratio), IL-10 and antioxidant enzymes were enhanced in OTH group. AP variability and baroreflex sensitivity were correlated with systolic AP, RPP, LF/HF ratio and inflammatory and oxidative stress parameters. ConclusionThe combination of HCTZ plus concurrent exercise training induced additional positive adaptations in cardiovascular autonomic control, inflammation and redox balance in ovariectomized SHR. Therefore, combining exercise and medication may represent a promising strategy for managing classic and remaining cardiovascular risks in AH.
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Referências
- Agarwal D, 2009, HYPERTENSION, V54, P1393, DOI 10.1161/HYPERTENSIONAHA.109.135459
- Baker SE, 2018, HYPERTENSION, V72, P1236, DOI 10.1161/HYPERTENSIONAHA.118.11550
- Briones AM, 2009, HYPERTENSION, V54, P1206, DOI 10.1161/HYPERTENSIONAHA.109.136622
- Brito-Monzani J de O., 2021, EXP GERONTOL, V145
- Ceron CS, 2010, BRIT J PHARMACOL, V160, P77, DOI 10.1111/j.1476-5381.2010.00678.x
- CHAPLEAU MW, 1995, HYPERTENSION, V26, P341, DOI 10.1161/01.HYP.26.2.341
- Choudhry NK, 2022, HYPERTENSION, V79, pE1, DOI 10.1161/HYP.0000000000000203
- Coffey VG, 2017, J PHYSIOL-LONDON, V595, P2883, DOI 10.1113/JP272270
- Conti FF, 2015, AM J PHYSIOL-REG I, V309, pR1532, DOI 10.1152/ajpregu.00076.2015
- Corso LML, 2016, MED SCI SPORT EXER, V48, P2398, DOI 10.1249/MSS.0000000000001056
- da Palma RK, 2016, J APPL PHYSIOL, V121, P1032, DOI 10.1152/japplphysiol.00130.2016
- De Angelis K, 2005, BRAZ J MED BIOL RES, V38, P119, DOI 10.1590/S0100-879X2005000100018
- Done AJ, 2016, REDOX BIOL, V10, P191, DOI 10.1016/j.redox.2016.10.003
- Dörffel Y, 1999, HYPERTENSION, V34, P113, DOI 10.1161/01.HYP.34.1.113
- Eriksson JW, 2008, HYPERTENSION, V52, P1030, DOI 10.1161/HYPERTENSIONAHA.108.119404
- Filho AG, 2008, EXP PHYSIOL, V93, P589, DOI 10.1113/expphysiol.2007.014293
- Finimundi HC, 2007, J CARDIOVASC PHARM, V49, P275, DOI 10.1097/FJC.0b013e3180385ad7
- Ford ES, 2007, NEW ENGL J MED, V356, P2388, DOI 10.1056/NEJMsa053935
- Fukuzawa M, 2000, IMMUNOPHARMACOLOGY, V48, P65, DOI 10.1016/S0162-3109(00)00179-X
- GILES TD, 1987, AM J CARDIOL, V60, P103, DOI 10.1016/0002-9149(87)90994-5
- Grassi G, 2003, J HYPERTENS, V21, P1761, DOI 10.1097/00004872-200309000-00027
- Grégoire JP, 2002, J CLIN EPIDEMIOL, V55, P728, DOI 10.1016/S0895-4356(02)00400-6
- Hägg U, 2004, CLIN SCI, V107, P571
- Harrison DG, 2021, CIRC RES, V128, P847, DOI 10.1161/CIRCRESAHA.121.318082
- Irigoyen MC, 2005, HYPERTENSION, V46, P998, DOI 10.1161/01.HYP.0000176238.90688.6b
- Jessup JA, 2008, J AM SOC HYPERTENS, V2, P106, DOI 10.1016/j.jash.2007.10.005
- Kaur K, 2006, J MOL CELL CARDIOL, V41, P1023, DOI 10.1016/j.yjmcc.2006.08.005
- KOENIG W, 1991, J CARDIOVASC PHARM, V18, P349, DOI 10.1097/00005344-199109000-00007
- Köken T, 2004, CLIN BIOCHEM, V37, P50, DOI 10.1016/j.clinbiochem.2003.10.001
- LAKE CR, 1979, CLIN PHARMACOL THER, V26, P428, DOI 10.1002/cpt1979264428
- Laterza MC, 2007, HYPERTENSION, V49, P1298, DOI 10.1161/HYPERTENSIONAHA.106.085548
- Li JY, 2019, AM J HYPERTENS, V32, P1091, DOI 10.1093/ajh/hpz115
- LOWRY OH, 1951, J BIOL CHEM, V193, P265
- Mariappan N, 2007, AM J PHYSIOL-HEART C, V293, pH2726, DOI 10.1152/ajpheart.00376.2007
- MATSUKAWA T, 1991, AM J PHYSIOL, V261, pR690, DOI 10.1152/ajpregu.1991.261.3.R690
- Mu L, 2015, J HUM HYPERTENS, V29, P394, DOI 10.1038/jhh.2014.104
- Neri M, 2007, J CELL MOL MED, V11, P156, DOI 10.1111/j.1582-4934.2007.00009.x
- Pahlavani M, 2017, COMPR PHYSIOL, V7, P1137, DOI 10.1002/cphy.c160031
- Pedersen BK, 2015, SCAND J MED SCI SPOR, V25, P1, DOI 10.1111/sms.12581
- Peeters ACTM, 2001, EUR J CLIN INVEST, V31, P31, DOI 10.1046/j.1365-2362.2001.00743.x
- Pescatello LS, 2021, BMJ OPEN SPORT EXERC, V7, DOI 10.1136/bmjsem-2020-000895
- Pickkers P, 1999, HYPERTENSION, V33, P1043, DOI 10.1161/01.HYP.33.4.1043
- Qiu M, 2022, OXID MED CELL LONGEV, V2022, DOI 10.1155/2022/8244497
- Raheja P, 2012, HYPERTENSION, V60, P319, DOI 10.1161/HYPERTENSIONAHA.112.194787
- Ren CZ, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/7413963
- Renna BF, 2006, MED SCI SPORT EXER, V38, P847, DOI 10.1249/01.mss.0000218133.89584.a6
- Rinder MR, 2004, AM J PHYSIOL-REG I, V287, pR360, DOI 10.1152/ajpregu.00409.2003
- Rodriguez-Iturbe B, 2017, PHYSIOL REV, V97, P1127, DOI 10.1152/physrev.00031.2016
- Roush GC, 2018, J HYPERTENS, V36, P1247, DOI 10.1097/HJH.0000000000001691
- Roush GC, 2014, J CARDIOVASC PHARM T, V19, P5, DOI 10.1177/1074248413497257
- Sanches IC, 2012, MENOPAUSE, V19, P562, DOI 10.1097/gme.0b013e3182358c9c
- Barroso WKS, 2021, ARQ BRAS CARDIOL, V116, P516
- Shi P, 2010, CLIN EXP PHARMACOL P, V37, pE52, DOI 10.1111/j.1440-1681.2009.05234.x
- Shimojo GL, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01471
- Silva GJJ, 1997, HYPERTENSION, V30, P714, DOI 10.1161/01.HYP.30.3.714
- Souza SBC, 2007, HYPERTENSION, V50, P786, DOI 10.1161/HYPERTENSIONAHA.107.095000
- Studinger P., 2003, J PHYSL, V550, P583
- VARDAN S, 1983, JAMA-J AM MED ASSOC, V250, P2807, DOI 10.1001/jama.250.20.2807
- Whelton PK, 2018, J AM COLL CARDIOL, V71, pE127, DOI 10.1016/j.jacc.2017.11.006
- Wray DW, 2010, HYPERTENSION, V55, P1217, DOI 10.1161/HYPERTENSIONAHA.109.147058
- Wu KLH, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-212
- Xie HH, 2008, HYPERTENS RES, V31, P685, DOI 10.1291/hypres.31.685
- Xie HH, 2006, EUR J PHARMACOL, V543, P77, DOI 10.1016/j.ejphar.2006.05.034
- Yamamoto E, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039162
- Yazdani B, 2020, J CLIN HYPERTENS, V22, P2332, DOI 10.1111/jch.14067
- Zaleski AL, 2019, J HYPERTENS, V37, P1877, DOI 10.1097/HJH.0000000000002115
- Zhou B, 2021, LANCET, V398, P957, DOI 10.1016/S0140-6736(21)01330-1