Impaired Baroreflex Sensitivity in Anabolic Steroid Users

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSANTOS, Marcelo Rodrigues dos
dc.contributor.authorPORELLO, Rafael Armani
dc.contributor.authorSAYEGH, Ana L. C.
dc.contributor.authorHONG, Valeria
dc.contributor.authorTOSCHI-DIAS, Edgar
dc.contributor.authorBORTOLOTTO, Luiz A.
dc.contributor.authorYONAMINE, Mauricio
dc.contributor.authorNEGRAO, Carlos E.
dc.contributor.authorALVES, Maria-Janieire N. N.
dc.date.accessioned2013-10-11T21:31:46Z
dc.date.available2013-10-11T21:31:46Z
dc.date.issued2012
dc.description.abstractPurpose: Exacerbated sympathetic nerve activity and increased blood pressure have been documented in anabolic androgenic steroid users (AASU). We tested the hypothesis that arterial baroreflex sensitivity (BRS) and carotid distensibility would be reduced in AASU. Methods: Ten AASU and 10 age-paired anabolic androgenic steroid nonusers (AASNU) were studied. Both groups were involved in strength training (90% 1MR) and AASU were self-administered anabolic steroids for at least 2 years. The use of AAS was proved by urine. Heart rate (HR) was evaluated by EKG and blood pressure non-invasively on a beat to beat. BRS was analyzed by time domain through spontaneous fluctuations between systolic blood pressure (SBP) and HR. Carotid artery distensibility was measured by doppler (M-mode). Results: HR was higher in AASU compared to AASNU (69±3 vs. 59±3 bpm, P≤0.05). Systolic (123±4 vs. 118±2 mmHg, P=0.29), diastolic (72±2 vs. 67±2 mmHg, P=0.12) and mean blood pressure (90±3 vs. 85±2 mmHg, P=0.15) were not different between groups. BRS for increases (14.2±2 vs. 22.8±3 msec/mmHg, P=0.05) and decreases (13.3±1 vs. 19.2±2 msec/mmHg, P=0.04) were lower in AASU. Carotid distensibility was reduced in AASU (7±1 vs. 9±1 %, P≤0.05). Conclusion: Impaired BRS and reduced carotid distensibility may prematurely lead to increased cardiovascular risk in AASU.
dc.description.conferencedateAPR 21-25, 2012
dc.description.conferencelocalSan Diego - CA, EUA
dc.description.conferencenameExperimental Biology Meeting
dc.description.indexMEDLINE
dc.identifier.citationFASEB JOURNAL, v.26, 2012
dc.identifier.issn0892-6638
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/3138
dc.language.isoeng
dc.publisherFEDERATION AMER SOC EXP BIOL
dc.relation.ispartofFaseb Journal
dc.rightsrestrictedAccess
dc.rights.holderCopyright FEDERATION AMER SOC EXP BIOL
dc.subject.wosBiochemistry & Molecular Biology
dc.subject.wosBiology
dc.subject.wosCell Biology
dc.titleImpaired Baroreflex Sensitivity in Anabolic Steroid Users
dc.typeconferenceObject
dc.type.categorymeeting abstract
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalPORELLO, Rafael Armani:Univ Sao Paulo, Sch Med, Heart Inst InCor, Sao Paulo, Brazil
hcfmusp.author.externalYONAMINE, Mauricio:Univ Sao Paulo, Coll Pharmaceut Sci, Sao Paulo, Brazil
hcfmusp.contributor.author-fmusphcMARCELO RODRIGUES DOS SANTOS
hcfmusp.contributor.author-fmusphcANA LUIZA CARRARI SAYEGH
hcfmusp.contributor.author-fmusphcVALERIA APARECIDA DA COSTA HONG
hcfmusp.contributor.author-fmusphcEDGAR TOSCHI DIAS
hcfmusp.contributor.author-fmusphcLUIZ APARECIDO BORTOLOTTO
hcfmusp.contributor.author-fmusphcCARLOS EDUARDO NEGRAO
hcfmusp.contributor.author-fmusphcMARIA JANIEIRE DE NAZARE NUNES ALVES
hcfmusp.description.volume26
hcfmusp.origemWOS
hcfmusp.origem.wosWOS:000310711306276
hcfmusp.publisher.cityBETHESDA
hcfmusp.publisher.countryUSA
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