A new low-cost negative-pressure wound therapy versus a commercially available therapy device widely used to treat complex traumatic injuries: a prospective, randomized, non-inferiority trial

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorKAMAMOTO, Fabio
dc.contributor.authorLIMA, Ana Lucia Munhoz
dc.contributor.authorREZENDE, Marcelo Rosa de
dc.contributor.authorMATTAR-JUNIOR, Rames
dc.contributor.authorLEONHARDT, Marcos de Camargo
dc.contributor.authorKOJIMA, Kodi Edson
dc.contributor.authorSANTOS, Carla Chineze dos
dc.date.accessioned2018-03-06T15:18:34Z
dc.date.available2018-03-06T15:18:34Z
dc.date.issued2017
dc.description.abstractOBJECTIVES: Negative-pressure wound therapy has been widely adopted to reduce the complexity of treating a broad range of acute and chronic wounds. However, its cost is high. The objective of this study was to evaluate the following two different methods of negative-pressure wound therapy in terms of healing time: a low-cost method of negative-pressure wound therapy (a pressure stabilizer device connected to a hospital wall-vacuum system with a gauze-sealed dressing, USP) and the standard of care (vacuum-assisted closure, VAC). METHODS: This is a randomized, controlled, non-inferiority, unblinded trial. Patients admitted with complex injuries to a trauma center in a public referral hospital who were indicated for orthopedic surgery were randomized to a USP or VAC group. The primary outcome was the time required to achieve a ""ready for surgery condition'', which was defined as a wound bed with healthy granulation tissue and without necrosis or purulent secretion. Wound bed area contraction, granulation tissue growth and the direct costs of the dressings were secondary outcomes. RESULTS: Variation in area and granulation tissue growth were essentially the same between the systems, and healing time was equal between the groups (p= 0.379). In both systems, serial debridement increased wound area (p= 0.934), and granulation tissue was also increased (p= 0.408). The mean treatment cost was US$ 15.15 in the USP group and US$ 872.59 in the VAC group. CONCLUSIONS: For treating complex traumatic injuries, USP was non-inferior to and less expensive than VAC.
dc.description.indexMEDLINE
dc.description.sponsorshipCNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico) [400.804/2014-0]
dc.identifier.citationCLINICS, v.72, n.12, p.737-742, 2017
dc.identifier.doi10.6061/clinics/2017(12)04
dc.identifier.eissn1980-5322
dc.identifier.issn1807-5932
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/25629
dc.language.isoeng
dc.publisherHOSPITAL CLINICAS, UNIV SAO PAULO
dc.relation.ispartofClinics
dc.rightsopenAccess
dc.rights.holderCopyright HOSPITAL CLINICAS, UNIV SAO PAULO
dc.subjectNegative-Pressure Wound Therapy
dc.subjectWound Healing
dc.subjectWounds and Injuries
dc.subjectCost Savings
dc.subject.othervacuum-assisted closure
dc.subject.otherclinical-evaluation
dc.subject.wosMedicine, General & Internal
dc.titleA new low-cost negative-pressure wound therapy versus a commercially available therapy device widely used to treat complex traumatic injuries: a prospective, randomized, non-inferiority trial
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.citation.scopus13
hcfmusp.contributor.author-fmusphcFABIO KAMAMOTO
hcfmusp.contributor.author-fmusphcANA LUCIA LEI MUNHOZ LIMA
hcfmusp.contributor.author-fmusphcMARCELO ROSA DE REZENDE
hcfmusp.contributor.author-fmusphcRAMES MATTAR JUNIOR
hcfmusp.contributor.author-fmusphcMARCOS DE CAMARGO LEONHARDT
hcfmusp.contributor.author-fmusphcKODI EDSON KOJIMA
hcfmusp.description.beginpage737
hcfmusp.description.endpage742
hcfmusp.description.issue12
hcfmusp.description.volume72
hcfmusp.origemWOS
hcfmusp.origem.pubmed29319719
hcfmusp.origem.scieloSCIELO:S1807-59322017001200737
hcfmusp.origem.scopus2-s2.0-85040250468
hcfmusp.origem.wosWOS:000419730000004
hcfmusp.publisher.citySAO PAULO
hcfmusp.publisher.countryBRAZIL
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hcfmusp.scopus.lastupdate2024-05-10
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