CD57 Expression and Cytokine Production by T Cells in Lesional and Unaffected Skin from Patients with Psoriasis

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorBATISTA, Mariana D.
dc.contributor.authorTINCATI, Camilla
dc.contributor.authorMILUSH, Jeffrey M.
dc.contributor.authorHO, Emily L.
dc.contributor.authorNDHLOVU, Lishomwa C.
dc.contributor.authorYORK, Vanessa A.
dc.contributor.authorKALLAS, Esper G.
dc.contributor.authorKALIL, Jorge
dc.contributor.authorKEATING, Sheila M.
dc.contributor.authorNORRIS, Philip J.
dc.contributor.authorCHANG, David
dc.contributor.authorUNEMORI, Patrick
dc.contributor.authorLESLIE, Kieron S.
dc.contributor.authorMAURER, Toby
dc.contributor.authorLIAO, Wilson
dc.contributor.authorNIXON, Douglas F.
dc.date.accessioned2013-09-23T16:36:07Z
dc.date.available2013-09-23T16:36:07Z
dc.date.issued2013
dc.description.abstractBackground: The immunopathogenic mechanisms leading to psoriasis remain unresolved. CD57 is a marker of replicative inability and immunosenescence on CD8+ T cells and the proportion of CD57 expressing CD8+ T cells is increased in a number of inflammatory conditions. Methodology: We examined the expression of CD57 on T cells in the skin of patients affected with psoriasis, comparing lesional and unaffected skin. We also assessed functionality of the T cells by evaluating the secretion of several inflammatory cytokines (IL-17A, IFN-gamma, IL-2, IL-33, TNF-alpha, IL-21, IL-22, and IL-27), from cell-sorted purified CD4+ and CD8+ T cells isolated from lesional and unaffected skin biopsies of psoriasis patients. Principal Findings: We observed that the frequency of CD57+CD4+ and CD57+CD8+ T cells was significantly higher in unaffected skin of psoriasis patients compared to lesional skin. Sorted CD4+ T cells from psoriatic lesional skin produced higher levels of IL-17A, IL-22, and IFN-gamma compared to unaffected skin, while sorted CD8+ T cells from lesional skin produced higher levels of IL-17, IL-22, IFN-gamma, TNF-alpha, and IL-2 compared to unaffected skin. Conclusions/Significance: These findings suggest that T cells in unaffected skin from psoriasis patients exhibit a phenotype compatible with replicative inability. As they have a lower replicative capacity, CD57+ T cells are less frequent in lesional tissue due to the high cellular turnover.
dc.description.indexMEDLINE
dc.description.sponsorshipNational Institutes of Health (NIH) [AI64520, 5T32HL007185]
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [04/15856-9, 2010/05845-0]
dc.description.sponsorshipPeter and Shelagh Godsoe Family Foundation
dc.description.sponsorshipUCSF REAC [37710/521717]
dc.description.sponsorshipAmerican Academy of Neurology Clinical Research Training Fellowship
dc.description.sponsorshipNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIH-NIAMS) [5K08AR057763]
dc.description.sponsorshipInternational AIDS Society
dc.description.sponsorshipU.S. National Institutes of Health (NIH)
dc.description.sponsorshipUW Institute of Translational Health Sciences
dc.identifier.citationPLOS ONE, v.8, n.2, article ID e52144, 6p, 2013
dc.identifier.doi10.1371/journal.pone.0052144
dc.identifier.issn1932-6203
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/1763
dc.language.isoeng
dc.publisherPUBLIC LIBRARY SCIENCE
dc.relation.ispartofPlos One
dc.rightsopenAccess
dc.rights.holderCopyright PUBLIC LIBRARY SCIENCE
dc.subject.otherhuman keratinocytes
dc.subject.otheratopic-dermatitis
dc.subject.othergene-expression
dc.subject.otheril-22
dc.subject.otherdifferentiation
dc.subject.otherlymphocytes
dc.subject.otherimmunopathogenesis
dc.subject.otheractivation
dc.subject.otherimmunity
dc.subject.othersubset
dc.subject.wosMultidisciplinary Sciences
dc.titleCD57 Expression and Cytokine Production by T Cells in Lesional and Unaffected Skin from Patients with Psoriasis
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalTINCATI, Camilla:Univ Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA 94143 USA
hcfmusp.author.externalMILUSH, Jeffrey M.:Univ Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA 94143 USA
hcfmusp.author.externalHO, Emily L.:Univ Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA 94143 USA
hcfmusp.author.externalNDHLOVU, Lishomwa C.:Univ Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA 94143 USA
hcfmusp.author.externalYORK, Vanessa A.:Univ Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA 94143 USA
hcfmusp.author.externalKEATING, Sheila M.:Blood Syst Res Inst, San Francisco, CA USA; Univ Calif San Francisco, Dept Lab Med, San Francisco, CA USA
hcfmusp.author.externalNORRIS, Philip J.:Blood Syst Res Inst, San Francisco, CA USA; Univ Calif San Francisco, Dept Lab Med, San Francisco, CA USA; Univ Calif San Francisco, Dept Med, San Francisco, CA USA
hcfmusp.author.externalCHANG, David:Calif Pacific Med Ctr, San Francisco, CA USA
hcfmusp.author.externalUNEMORI, Patrick:Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA
hcfmusp.author.externalLESLIE, Kieron S.:Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA
hcfmusp.author.externalMAURER, Toby:Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA
hcfmusp.author.externalLIAO, Wilson:Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA
hcfmusp.author.externalNIXON, Douglas F.:Univ Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA 94143 USA
hcfmusp.citation.scopus9
hcfmusp.contributor.author-fmusphcMARIANA DIAS BATISTA
hcfmusp.contributor.author-fmusphcESPER GEORGES KALLAS
hcfmusp.contributor.author-fmusphcJORGE ELIAS KALIL FILHO
hcfmusp.description.articlenumbere52144
hcfmusp.description.issue2
hcfmusp.description.volume8
hcfmusp.origemWOS
hcfmusp.origem.pubmed23468834
hcfmusp.origem.scopus2-s2.0-84874533147
hcfmusp.origem.wosWOS:000315524900002
hcfmusp.publisher.citySAN FRANCISCO
hcfmusp.publisher.countryUSA
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hcfmusp.remissive.sponsorshipFAPESP
hcfmusp.remissive.sponsorshipNIH
hcfmusp.scopus.lastupdate2024-04-12
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