Polymorphisms of ICAM-1 and IL-6 genes related to endometriosis in a sample of Brazilian women
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Citações na Scopus
6
Tipo de produção
article
Data de publicação
2016
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER/PLENUM PUBLISHERS
Autores
BESSA, Nathalie Zamagni
FRANCISCO, Daniela de Oliveira
GUEUVOGHLANIAN-SILVA, Barbara Yasmim
Citação
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, v.33, n.11, p.1487-1492, 2016
Resumo
This study investigated the possibility of K469E (rs5498) and G241R (rs1799969) polymorphisms, in ICAM-1 gene, and G634C (rs1800796), in IL-6 gene, being associated with the occurrence of endometriosis in a sample of Brazilian women. We genotyped 200 women (100 in control group and 100 in endometriosis group) by PCR-RFLP technique for G634C, K469E, and G241R polymorphisms. No significant difference was observed in genotypic frequency between control and endometriosis groups for G634C and K469E polymorphisms (p = 0.61 and p = 0.22, respectively). In addition, no significant difference between stages I-II and III-IV of the disease was found for both SNPs (p = 0.63 and p = 0.24, respectively). All individuals were wild homozygotes for G241R polymorphism. This study suggests that polymorphisms K469E, G241R, and G634C are not associated with increased susceptibility to endometriosis in Brazilian women.
Palavras-chave
Endometriosis, Intercellular adhesion molecule-1, Interleukin-6, Polymorphism, Brazilian population
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