Gastric fundus submucosa as a site for islets transplantation: An experimental study

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art_MESQUITA_Gastric_fundus_submucosa_as_a_site_for_islets_2018.PDF (463.74 KB)
Citações na Scopus
2
Tipo de produção
article
Data de publicação
2018
DOI
Scopus
Web of Science
PubMed
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Título do Volume
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ELSEVIER SCI LTD
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Citação
ANNALS OF MEDICINE AND SURGERY, v.28, p.1-5, 2018
Projetos de Pesquisa
Unidades Organizacionais
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Resumo
Background: Islets of Langerhans transplantation is a promising alternative for glycemic control in patients with type 1 diabetes. The graft site is a factor that has large impact on the functioning of this transplant, and the stomach appears to be a promising location. Our objective is to describe a new experimental model for the grafting of Islets of Langerhans in rat stomachs. Methodology: Islets of Langerhans were extracted from 45 isogenic male rats of the Lewis lineage and transplanted into 9 isogenic rats of the Wistar lineage; 5 in the gastric body submucosa, and 4 in the gastric fundus submucosa. Normoglycemia was defined as two successive measurements of < 250 mg/dL. No immunosuppression was used. The two groups glycemia control improvement were compared with t-student test. Results: The results obtained following the transplantation of the islets in 9 rats showed between 995 and 2310 islets transplanted (mean of 1367). The rats from the gastric submucosa group had a better glycemic level improvement, with a confidence equal to 83.94%. Conclusion: Islets graft into the gastric fundus submucosa is a viable model with potential for adequate glycemic control. This model gives potential for new perspectives and future studies in this area.
Palavras-chave
Gastric fundus submucosa, Islets transplantation, Type 1 diabetes
URI
https://observatorio.fm.usp.br/handle/OPI/26323
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MGT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/IMREA
Artigos e Materiais de Revistas Científicas - LIM/02
Artigos e Materiais de Revistas Científicas - LIM/37
Artigos e Materiais de Revistas Científicas - ODS/03