Melanoma in Children, Adolescents, and Young Adults: A Clinical Pathological Study in a Brazilian Population

Página do item simplificado
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSANCHEZ, Paula C. F.
dc.contributor.authorNODA, Aliene Y. I.
dc.contributor.authorFRANCO, Dilcilea D. G. S.
dc.contributor.authorLOURENCO, Silvia V.
dc.contributor.authorSANGUEZA, Martin
dc.contributor.authorNETO, Cyro F.
dc.date.accessioned2015-02-06T19:54:16Z
dc.date.available2015-02-06T19:54:16Z
dc.date.issued2014
dc.description.abstractMalignant melanoma in children, adolescents, and young adults is unusual, especially before puberty. In children (age, 0-14 years), most primary lesions are thick and atypical (amelanotic, simulating pyogenic granuloma). In the population of adolescents and young adults (age, 15-39 years), melanoma is the third most common cancer, only behind lymphoma and breast cancer. Our study investigated the records of 89 patients diagnosed with cutaneous melanoma at age 0-39 years at Hospital das Cl nicas, Medical School, University of Sao Paulo between 1992 and 2002. They were divided into group A (0-14 years of age) and group B (15-39 years of age). The histopathology of all cases was reexamined. Statistical analysis of the data presented was performed, and the obtained data were compared with the literature. The frequency of melanoma in the group aged 15-39 years was higher in women, and the most affected site was the trunk. Additionally, melanomas were more frequent at an earlier age in patients with family history of melanoma (P = 0.014). Most cases were diagnosed, at histopathology, as superficial spreading melanoma. Thick nodular melanomas with Breslow values higher than 2 mm were associated with lymph node metastasis (P < 0.05). Our study revealed that melanoma in children, adolescents, and young adults may present peculiar behavior and outcome, which might reflect the genetic and yet not fully unraveled pathogenesis of this complex disease.
dc.description.indexMEDLINE
dc.identifier.citationAMERICAN JOURNAL OF DERMATOPATHOLOGY, v.36, n.8, p.620-628, 2014
dc.identifier.eissn1533-0311
dc.identifier.issn0193-1091
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/8764
dc.language.isoeng
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.relation.ispartofAmerican Journal of Dermatopathology
dc.rightsrestrictedAccess
dc.rights.holderCopyright LIPPINCOTT WILLIAMS & WILKINS
dc.subjectmelanoma
dc.subjectchildren
dc.subjectadolescents
dc.subjectyoung adults
dc.subject.othercutaneous malignant-melanoma
dc.subject.otherspitzoid melanocytic tumors
dc.subject.othersentinel lymph-nodes
dc.subject.otherpediatric melanoma
dc.subject.othersingle-institution
dc.subject.otherunited-states
dc.subject.otherrisk-factor
dc.subject.othersun
dc.subject.otherexperience
dc.subject.otherchildhood
dc.subject.wosDermatology
dc.titleMelanoma in Children, Adolescents, and Young Adults: A Clinical Pathological Study in a Brazilian Population
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryBolívia
hcfmusp.affiliation.countryisobo
hcfmusp.author.externalFRANCO, Dilcilea D. G. S.:Univ Sao Paulo, Sch Med, Dept Dermatol, BR-05403000 Sao Paulo, Brazil
hcfmusp.author.externalSANGUEZA, Martin:Hosp Pbrero, Dept Surg Pathol, La Paz, Bolivia
hcfmusp.citation.scopus8
hcfmusp.contributor.author-fmusphcPAULA CRISTINA DE FARIA SANCHEZ
hcfmusp.contributor.author-fmusphcALIENE YAYOI ISHIHARA NODA
hcfmusp.contributor.author-fmusphcSILVIA VANESSA LOURENCO
hcfmusp.contributor.author-fmusphcCYRO FESTA NETO
hcfmusp.description.beginpage620
hcfmusp.description.endpage628
hcfmusp.description.issue8
hcfmusp.description.volume36
hcfmusp.origemWOS
hcfmusp.origem.scopus2-s2.0-84905005350
hcfmusp.origem.wosWOS:000340144800004
hcfmusp.publisher.cityPHILADELPHIA
hcfmusp.publisher.countryUSA
hcfmusp.relation.referenceAldrink JH, 2009, J PEDIATR SURG, V44, P1514, DOI 10.1016/j.jpedsurg.2008.12.003
hcfmusp.relation.referenceBalch CM, 2009, J CLIN ONCOL, V27, P6199, DOI 10.1200/JCO.2009.23.4799
hcfmusp.relation.referenceBandarchi B, 2010, DERMATOL RES PRACT, V2010, P1, DOI [DOI 10.1155/2010/583748, 10.1155/2010/583748]
hcfmusp.relation.referenceBataille V, 2013, MED HYPOTHESES, V81, P846, DOI 10.1016/j.mehy.2013.05.031
hcfmusp.relation.referenceBataille V, 2004, EUR J CANCER, V40, P429, DOI 10.1016/j.ejca.2003.09.030
hcfmusp.relation.referenceBerk DR, 2010, PEDIATR DERMATOL, V27, P244, DOI 10.1111/j.1525-1470.2009.01078.x
hcfmusp.relation.referenceBleyer A, 2006, NIH PUB, V06-5767
hcfmusp.relation.referenceBradford PT, 2009, ARCH DERMATOL, V145, P427, DOI 10.1001/archdermatol.2008.609
hcfmusp.relation.referenceBressac-de-Paillerets B, 2002, BIOCHIMIE, V84, P67, DOI 10.1016/S0300-9084(01)01360-8
hcfmusp.relation.referenceBusam KJ, 2009, AM J SURG PATHOL, V33, P1386, DOI 10.1097/PAS.0b013e3181ac1927
hcfmusp.relation.referenceCadili A, 2010, CAN J SURG, V53, P32
hcfmusp.relation.referenceCerroni L, 2010, AM J SURG PATHOL, V34, P314, DOI 10.1097/PAS.0b013e3181cf7fa0
hcfmusp.relation.referenceChang YM, 2009, INT J EPIDEMIOL, V38, P814, DOI 10.1093/ije/dyp166
hcfmusp.relation.referenceCordoro KM, 2013, J AM ACAD DERMATOL, V68, P913, DOI 10.1016/j.jaad.2012.12.953
hcfmusp.relation.referenceDaniotti M, 2009, J INVEST DERMATOL, V129, P1759, DOI 10.1038/jid.2008.422
hcfmusp.relation.referenceDurbec F, 2012, BRIT J DERMATOL, V166, P727, DOI 10.1111/j.1365-2133.2011.10772.x
hcfmusp.relation.referenceFerrari A, 2005, PEDIATRICS, V115, P649, DOI 10.1542/peds.2004-0471
hcfmusp.relation.referenceGamba CS, 2013, JAMA DERMATOL JUN, P1
hcfmusp.relation.referenceGerami P, 2013, AM J SURG PATHOL, V37, P1387, DOI 10.1097/PAS.0b013e31828fc283
hcfmusp.relation.referenceGosh P, 2009, EXPERT REV DERMATOL, V4, P131
hcfmusp.relation.referenceGualandri L, 2009, J EUR ACAD DERMATOL, V23, P283, DOI 10.1111/j.1468-3083.2008.03041.x
hcfmusp.relation.referenceHan D, 2012, ANN SURG ONCOL, V19, P3888, DOI 10.1245/s10434-012-2554-5
hcfmusp.relation.referenceJhappan C, 2003, ONCOGENE, V22, P3099, DOI 10.1038/sj.onc.1206450
hcfmusp.relation.referenceKirkwood JM, 2009, SEMIN ONCOL, V36, P419, DOI 10.1053/j.seminoncol.2009.07.001
hcfmusp.relation.referenceLambie M, 2011, ANN PLAS SURG, V67, P85, DOI 10.1097/SAP.0b013e3181e0fcbc
hcfmusp.relation.referenceLewis KG, 2008, DERMATOL SURG, V34, P152, DOI 10.1111/j.1524-4725.2007.34032.x
hcfmusp.relation.referenceLohmann CM, 2002, AM J SURG PATHOL, V26, P47, DOI 10.1097/00000478-200201000-00005
hcfmusp.relation.referenceLudgate MW, 2009, CANCER, V115, P631, DOI 10.1002/cncr.24047
hcfmusp.relation.referenceMark PP, 2008, J INVEST DERMATOL, V128, P2905
hcfmusp.relation.referenceMones JM, 2003, AM J DERMATOPATH, V25, P223, DOI 10.1097/00000372-200306000-00007
hcfmusp.relation.referenceNeier M, 2012, J PEDIAT HEMATOL ONC, V34, pS51, DOI 10.1097/MPH.0b013e31824e3852
hcfmusp.relation.referencePappo AS, 2003, EUR J CANCER, V39, P2651, DOI 10.1016/j.ejca.2003.06.001
hcfmusp.relation.referenceParadela S, 2011, ARCH PATHOL LAB MED, V135, P307, DOI 10.1043/2009-0503-RA.1
hcfmusp.relation.referenceParadela S, 2010, CANCER-AM CANCER SOC, V116, P4334, DOI 10.1002/cncr.25222
hcfmusp.relation.referenceRaskin L, 2011, AM J SURG PATHOL, V35, P243, DOI 10.1097/PAS.0b013e31820393ee
hcfmusp.relation.referenceRouhani Panta, 2008, Cancer Control, V15, P248
hcfmusp.relation.referenceStrouse JJ, 2005, J CLIN ONCOL, V23, P4735, DOI 10.1200/JCO.2005.02.899
hcfmusp.relation.referenceSu LD, 2003, CANCER, V97, P499, DOI 10.1002/cncr.11074
hcfmusp.relation.referenceThomas JM, 2008, NAT CLIN PRACT ONCOL, V5, P18, DOI 10.1038/ncponc1014
hcfmusp.relation.referenceTucker MA, 1997, JAMA-J AM MED ASSOC, V277, P1439, DOI 10.1001/jama.277.18.1439
hcfmusp.relation.referenceWeir HK, 2011, J AM ACAD DERMATOL, V65
hcfmusp.relation.referenceWhite RL, 2011, ANN SURG ONCOL, V18, P3593, DOI 10.1245/s10434-011-1826-9
hcfmusp.scopus.lastupdate2024-05-10
relation.isAuthorOfPublication257e141e-c5ec-470d-8584-2378014676c2
relation.isAuthorOfPublication6b22be4f-0f31-4772-9999-4a38ed89e0e0
relation.isAuthorOfPublication5daa3ec5-b62d-4637-93ed-cc9082669dd4
relation.isAuthorOfPublication02795968-5c04-4c21-863d-e11038aba5b8
relation.isAuthorOfPublication.latestForDiscovery257e141e-c5ec-470d-8584-2378014676c2
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
art_SANCHEZ_Melanoma_in_Children_Adolescents_and_Young_Adults_A_2014.PDF
Tamanho:
637.64 KB
Formato:
Adobe Portable Document Format
Descrição:
publishedVersion (English)
Baixar
Coleções
Artigos e Materiais de Revistas Científicas - LIM/06
Artigos e Materiais de Revistas Científicas - FM/MDT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - ODS/03